HitPredict

Interactor 1: PSD10 (O75832)
26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK))
Gene: PSMD10

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030674 - protein-macromolecule adaptor activity and 1 others more... GO:0043005 - neuron projection
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 226 Hs			1 758
+	Hs
		496871 ANK2_HUMAN (11-224): 2.93e-64: 217: 28.29		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496939 ANK3_HUMAN (11-224): 5.98e-60: 205: 29.22		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		251021 ANK3_RAT (11-224): 2.56e-59: 203: 27.89		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94107 ANK3_RAT (11-224): 2.56e-59: 203: 27.89		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Hs
		60284 POTEF_HUMAN (1-125): 1.39e-24: 103: 22.40		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		161294 MYPT1_HUMAN (146-226): 1.06e-18: 85.9: 30.86		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		883603 RIPK4_HUMAN (10-224): 1.17e-53: 185: 26.39		ZN469_HUMAN (7-623): 9.52e-09: 61.2: 10.94
+	Hs
		1295178 Q9H4D1_HUMAN (10-224): 1.95e-53: 184: 26.39		ZN469_HUMAN (7-623): 9.52e-09: 61.2: 10.94
+	Hs
		1057007 RAI14_HUMAN (1-109): 2.71e-20: 90.8: 23.85		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57
+	Hs
		310053 TNKS1_HUMAN (14-212): 3.51e-13: 70.1: 27.39		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57
+	Hs
		1336188 KDIS_HUMAN (1-142): 3.7e-32: 125: 25.52		MAGE1_HUMAN (222-587): 4.83e-09: 61.9: 16.22
+	Hs
		1056981 TNKS2_HUMAN (75-215): 2.56e-10: 61.6: 31.25		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57
+	Dm
		1182373 Q7KU92_DROME (133-224): 5.27e-20: 90.1: 22.83		Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96
+	Dm
		1362722 ANKHM_DROME (4-95): 1.54e-17: 82.8: 23.66		Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96