HitPredict

Interactor 1: PSD10 (O75832)
26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK))
Gene: PSMD10

Interactor 2: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.821

Property	Details
Experiments	17881001, 11900540
Identification Methods	enzymatic study, two hybrid, affinity chromatography technology, pull down, unspecified method
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank~Pkinase, Ank_2~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 226 Hs			1 303
+	Hs
		960304 MIB1_HUMAN (1-226): 1.24e-58: 200: 29.87		CDK5_HUMAN (3-301): 5.52e-124: 357: 43.09
+	Mm
		673242 PSD10_MOUSE (48-224): 4.5e-48: 159: 29.78		CDK4_MOUSE (1-299): 5.01e-126: 363: 95.65
+	Hs
		625621 RAI14_HUMAN (1-109): 2.71e-20: 90.8: 23.85		CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22
+	Hs
		161308 MYPT1_HUMAN (146-226): 1.06e-18: 85.9: 30.86		CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22
+	Hs
		161289 MYPT1_HUMAN (146-226): 1.06e-18: 85.9: 30.86		CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24