HitPredict

Interactor 1: PSD10 (O75832)
26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK))
Gene: PSMD10

Interactor 2: PRS7 (P35998)
26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2)
Gene: PSMC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.943

Property	Details
Experiments	17353931, 33961781, 26186194, 28539385, 35271311, 19490896
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AAA_lid_3~Ank, AAA_lid_3~Ank_2
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 226 Hs			1 433
+	Hs
		730357 Q9H4D1_HUMAN (10-224): 1.95e-53: 184: 26.39		PRS7_HUMAN (1-433): 3.93e-144: 419: 100.00
+	Hs
		276152 PSD10_HUMAN (1-226): 8.43e-70: 214: 100.00		PRS6B_HUMAN (3-425): 2.12e-121: 361: 35.93
+	Hs
		276164 PSD10_HUMAN (1-226): 8.43e-70: 214: 100.00		PRS8_HUMAN (35-430): 2.5e-119: 355: 45.20
+	Hs
		276166 PSD10_HUMAN (1-226): 8.43e-70: 214: 100.00		PRS10_HUMAN (39-429): 1.33e-119: 355: 42.46
+	Mm
		872750 PSD10_MOUSE (48-224): 4.5e-48: 159: 29.78		PRS6B_MOUSE (3-425): 5.33e-121: 360: 35.93
+	Sc
		837206 PSD10_YEAST (76-219): 1.91e-09: 57.8: 32.90		PRS8_YEAST (16-417): 3.49e-154: 444: 44.53
+	Sc
		703929 PSD10_YEAST (76-219): 1.91e-09: 57.8: 32.90		PRS7_YEAST (1-433): 1.68e-127: 378: 69.59