HitPredict

Interactor 1: AP1G2 (O75843)
AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad)
Gene: AP1G2

Interactor 2: AP2M1 (Q96CW1)
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: AP2M1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adap_comp_sub~Adaptin_N, Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0006886 - intracellular protein transport GO:0016192 - vesicle-mediated transport GO:0035615 - clathrin adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 785 Hs			1 435
+	Hs
		212655 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Hs
		212662 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP1M1_HUMAN (2-434): 5.69e-170: 484: 38.85
+	Mm
		612130 AP1G1_MOUSE (1-785): 0: 735: 58.69		AP1M1_MOUSE (2-434): 2e-169: 483: 38.62
+	Hs
		212676 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP1M2_HUMAN (2-434): 5.35e-163: 467: 37.70
+	Hs
		276398 AP1G2_HUMAN (1-785): 0: 706: 100.00		AP1M2_HUMAN (2-434): 5.35e-163: 467: 37.70
+	At
		187128 AP1G1_ARATH (1-780): 0: 624: 37.92		AP1M2_ARATH (2-434): 3.73e-164: 470: 37.90
+	At
		1195473 AP1G1_ARATH (1-780): 0: 624: 37.92		AP1M1_ARATH (2-434): 2.25e-159: 458: 37.90
+	Rn
		577193 AP2A2_RAT (1-776): 0: 555: 24.97		AP2M1_RAT (1-435): 1.03e-178: 507: 100.00
+	Hs
		302192 AP2A2_HUMAN (1-776): 0: 547: 25.30		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Hs
		925969 AP2B1_HUMAN (29-737): 3.35e-174: 527: 15.35		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Hs
		321614 AP2A1_HUMAN (1-776): 3.57e-173: 525: 24.34		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Ce
		725364 Q22601_CAEEL (1-764): 1.54e-178: 538: 23.88		AP2M_CAEEL (1-435): 3.73e-172: 491: 80.95
+	Hs
		925992 AP2B1_HUMAN (29-737): 3.35e-174: 527: 15.35		AP1M1_HUMAN (2-434): 5.69e-170: 484: 38.85
+	Dm
		248292 AP2A_DROME (5-770): 6.72e-173: 523: 24.15		O62530_DROME (1-435): 7.78e-171: 487: 86.56
+	Hs
		926066 AP2B1_HUMAN (29-737): 3.35e-174: 527: 15.35		AP1M2_HUMAN (2-434): 5.35e-163: 467: 37.70
+	At
		187886 APBLB_ARATH (29-776): 3.81e-170: 515: 15.75		AP2M_ARATH (2-435): 8.67e-160: 459: 47.27
+	Sc
		961964 AP1G1_YEAST (6-775): 5.6e-177: 530: 29.43		AP1M1_YEAST (1-434): 1.87e-145: 424: 35.08
+	Hs
		925959 AP2B1_HUMAN (29-737): 3.35e-174: 527: 15.35		STON2_HUMAN (146-433): 1.58e-62: 219: 22.85
+	Hs
		1014058 AP1B1_HUMAN (29-746): 2.43e-169: 515: 15.60		STON2_HUMAN (146-433): 1.58e-62: 219: 22.85
+	Sc
		752424 AP1G1_YEAST (6-775): 5.6e-177: 530: 29.43		APM2_YEAST (1-133): 1.91e-16: 83.6: 25.18