Protein: LIPA1
Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1)

Gene: LIPA1, PPFIA1
Organism: Homo sapiens
Interactions: 185
UniProt ID: Q13136

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005925 - focal adhesion
GO:0005938 - cell cortex
GO:0007160 - cell-matrix adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

522656

PTPRF
Receptor-type tyrosine-protein phosphatase F

4

11

Small-scale

0.898

High

1095609

GIT1
ARF GTPase-activating protein GIT1

3

8

Small-scale

0.883

High

1095523

PTPRS
Receptor-type tyrosine-protein phosphatase S

3

11

Small-scale

0.845

High

658880

PTPRD
Receptor-type tyrosine-protein phosphatase delta

2

11

Small-scale

0.786

High

1057602

CDK18
Cyclin-dependent kinase 18

2

12

High-throughput

0.783

High

1095521

LIPA1
Liprin-alpha-1

2

18

Small-scale

0.778

High

276368

LIPA2
Liprin-alpha-2

2

16

Small-scale

0.768

High

411847

NTRK1
High affinity nerve growth factor receptor

2

17

High-throughput

0.754

High

1095585

GRIP2
Glutamate receptor-interacting protein 2

2

14

Small-scale

0.754

High

717789

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

7

4

High-throughput

0.751

High

994201

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

6

14

High-throughput

0.742

High

977478

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

6

14

High-throughput

0.738

High

262379

DTNB
Dystrobrevin beta

4

4

High-throughput

0.705

High

1095539

MK06
Mitogen-activated protein kinase 6

1

10

High-throughput

0.691

High

729797

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.691

High

966262

1433G
14-3-3 protein gamma

4

20

High-throughput

0.691

High

1095522

GPS2
G protein pathway suppressor 2

4

1

High-throughput

0.691

High

1095531

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

3

5

High-throughput

0.687

High

821095

TXLNA
Alpha-taxilin

3

17

High-throughput

0.676

High

1095596

PICK1
PRKCA-binding protein

1

0

High-throughput

0.656

High

690965

1433T
14-3-3 protein theta

3

20

High-throughput

0.650

High

1049250

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

1095574

CNKR1
Connector enhancer of kinase suppressor of ras 1

1

17

Small-scale

0.647

High

767188

MERL
Merlin

2

11

High-throughput

0.628

High

1095548

L2GL2
LLGL scribble cell polarity complex component 2

2

3

High-throughput

0.628

High

271621

LIPA3
Liprin-alpha-3

1

15

Small-scale

0.621

High

1095556

LIPB1
Liprin-beta-1

1

18

Small-scale

0.621

High

1095563

LIPB2
Liprin-beta-2

1

18

Small-scale

0.621

High

1095549

BTNL9
Butyrophilin-like protein 9

1

9

High-throughput

0.618

High

1095542

F161A
Protein FAM161A

2

0

High-throughput

0.618

High

400752

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.618

High

440055

LCK
Tyrosine-protein kinase Lck

1

10

High-throughput

0.618

High

463495

LYN
Tyrosine-protein kinase Lyn

1

10

High-throughput

0.618

High

541461

FGFR1
Fibroblast growth factor receptor 1

1

13

High-throughput

0.618

High

710213

EPHA2
Ephrin type-A receptor 2

1

6

High-throughput

0.618

High

711883

LTK
Leukocyte tyrosine kinase receptor

1

17

High-throughput

0.618

High

845623

MUC18
Cell surface glycoprotein MUC18

1

3

High-throughput

0.618

High

891143

GSK3A
Glycogen synthase kinase-3 alpha

1

15

High-throughput

0.618

High

891504

GSK3B
Glycogen synthase kinase-3 beta

1

17

High-throughput

0.618

High

1004046

CXAR
Coxsackievirus and adenovirus receptor

1

2

High-throughput

0.618

High

1095528

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

14

High-throughput

0.618

High

1095537

NTRK2
BDNF/NT-3 growth factors receptor

1

19

High-throughput

0.618

High

1095567

LNX1
E3 ubiquitin-protein ligase LNX

1

15

Small-scale

0.618

High

1095578

AURKB
Aurora kinase B

1

16

High-throughput

0.618

High

1095597

LATS2
Serine/threonine-protein kinase LATS2

1

20

High-throughput

0.618

High

1095605

ALK
ALK tyrosine kinase receptor

1

15

High-throughput

0.618

High

908696

CCNH
Cyclin-H

3

1

High-throughput

0.617

High

1095599

MBIP1
MAP3K12-binding inhibitory protein 1

2

0

High-throughput

0.613

High

1095524

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

2

2

High-throughput

0.606

High

1095532

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

2

5

High-throughput

0.606

High

424503

PAI2
Plasminogen activator inhibitor 2

2

0

High-throughput

0.602

High

1095557

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.602

High

990171

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.601

High

1095569

BRK1
Protein BRICK1

2

2

High-throughput

0.601

High

1095588

DNJC5
DnaJ homolog subfamily C member 5

2

5

High-throughput

0.595

High

241560

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

373906

RASN
GTPase NRas

2

19

High-throughput

0.584

High

375471

RASK
GTPase KRas

2

19

High-throughput

0.584

High

975011

ARF6
ADP-ribosylation factor 6

2

3

High-throughput

0.584

High

977974

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

353686

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.580

High

1095607

ING4
Inhibitor of growth protein 4

2

0

Small-scale

0.576

High

1095545

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.575

High

1095554

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

11

High-throughput

0.575

High

286648

STX11
Syntaxin-11

2

5

High-throughput

0.574

High

1095562

TTC9B
Tetratricopeptide repeat protein 9B

2

4

High-throughput

0.574

High

177117

ERC2
ERC protein 2

1

18

Small-scale

0.573

High

396023

ESR1
Estrogen receptor

2

15

High-throughput

0.571

High

1095529

ELOA1
Elongin-A

2

4

High-throughput

0.553

High

648496

FGFR4
Fibroblast growth factor receptor 4

1

14

High-throughput

0.553

High

799056

BRCA1
Breast cancer type 1 susceptibility protein

1

10

High-throughput

0.552

High

568555

TNNT1
Troponin T, slow skeletal muscle

1

1

High-throughput

0.541

High

1095583

NECD
Necdin

1

9

High-throughput

0.541

High

1095566

CEP70
Centrosomal protein of 70 kDa

1

0

High-throughput

0.536

High

300650

KRT37
Keratin, type I cuticular Ha7

1

9

High-throughput

0.536

High

867088

CAPZB
F-actin-capping protein subunit beta

1

5

High-throughput

0.536

High

951968

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

14

High-throughput

0.536

High

971470

1433E
14-3-3 protein epsilon

1

5

High-throughput

0.536

High

1095527

CUL2
Cullin-2

1

8

High-throughput

0.536

High

1095541

KIF7
Kinesin-like protein KIF7

1

4

High-throughput

0.536

High

1095551

TPGS1
Tubulin polyglutamylase complex subunit 1

1

1

High-throughput

0.536

High

1095582

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

1095594

E41L5
Band 4.1-like protein 5

1

9

High-throughput

0.536

High

1095610

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.536

High

952791

ACTB
Actin, cytoplasmic 1

1

16

High-throughput

0.515

High

655810

TBG1
Tubulin gamma-1 chain

1

0

High-throughput

0.513

High

1095536

CART

1

0

High-throughput

0.513

High

1095565

I17RE
Interleukin-17 receptor E

1

0

High-throughput

0.513

High

1095593

GBA2
Non-lysosomal glucosylceramidase

1

0

High-throughput

0.513

High

1095608

CBPC1
Cytosolic carboxypeptidase 1

1

1

High-throughput

0.508

High

1095573

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

10

High-throughput

0.501

High

848610

MAGA9
Melanoma-associated antigen 9

1

9

High-throughput

0.489

High

126574

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

1095606

CC14A
Dual specificity protein phosphatase CDC14A

1

4

High-throughput

0.479

High

226018

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

246572

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.479

High

299175

FLOT1
Flotillin-1

1

4

High-throughput

0.479

High

345744

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

374563

RASH
GTPase HRas

1

14

High-throughput

0.479

High

436857

K1C18
Keratin, type I cytoskeletal 18

1

4

High-throughput

0.479

High

466231

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

540431

LAMP1
Lysosome-associated membrane glycoprotein 1

1

7

High-throughput

0.479

High

581017

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

601264

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

603959

CXA1
Gap junction alpha-1 protein

1

6

High-throughput

0.479

High

642837

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.479

High

699729

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

9

High-throughput

0.479

High

715566

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.479

High

730558

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

808047

CDN1A
Cyclin-dependent kinase inhibitor 1

1

1

High-throughput

0.479

High

860725

RS10
Small ribosomal subunit protein eS10

1

4

High-throughput

0.479

High

901791

RAB9A
Ras-related protein Rab-9A

1

6

High-throughput

0.479

High

910033

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

941778

ARL4C
ADP-ribosylation factor-like protein 4C

1

9

High-throughput

0.479

High

942591

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

17

High-throughput

0.479

High

953419

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955113

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

956272

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.479

High

962005

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

962728

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

976238

RB11A
Ras-related protein Rab-11A

1

2

High-throughput

0.479

High

988329

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

1015404

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1041037

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1095526

HDAC1
Histone deacetylase 1

1

13

High-throughput

0.479

High

1095530

CAPR1
Caprin-1

1

1

High-throughput

0.479

High

1095533

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.479

High

1095534

NCOA2
Nuclear receptor coactivator 2

1

8

Small-scale

0.479

High

1095535

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1095538

OCLN
Occludin

1

1

High-throughput

0.479

High

1095543

AR13B
ADP-ribosylation factor-like protein 13B

1

5

High-throughput

0.479

High

1095544

AMOT
Angiomotin

1

17

High-throughput

0.479

High

1095546

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.479

High

1095550

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

1095552

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1095561

ARL14
ADP-ribosylation factor-like protein 14

1

5

High-throughput

0.479

High

1095570

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1095571

ESR2
Estrogen receptor beta

1

15

High-throughput

0.479

High

1095580

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

1095581

TRNT1
CCA tRNA nucleotidyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

1095586

TOLIP
Toll-interacting protein

1

2

High-throughput

0.479

High

1095587

VP33B
Vacuolar protein sorting-associated protein 33B

1

3

High-throughput

0.479

High

1095589

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1095590

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1095592

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1095595

E41LA
Band 4.1-like protein 4A

1

9

High-throughput

0.479

High

1095598

RNC
Ribonuclease 3

1

1

High-throughput

0.479

High

1095601

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1095603

BRPF3
Bromodomain and PHD finger-containing protein 3

1

4

High-throughput

0.479

High

1095604

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.479

High

1024542

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1095525

MTM1
Myotubularin

1

0

High-throughput

0.458

High

1095564

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1095591

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1095559

CNTRB
Centrobin

1

18

High-throughput

0.445

High

1095600

CTNL1
Alpha-catulin

1

1

Small-scale

0.445

High

139863

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

1

High-throughput

0.437

High

189546

STX7
Syntaxin-7

1

4

High-throughput

0.437

High

259884

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.437

High

279356

TULP3
Tubby-related protein 3

1

3

High-throughput

0.437

High

327247

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.437

High

341043

DIRA3
GTP-binding protein Di-Ras3

1

3

High-throughput

0.437

High

406128

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.437

High

588588

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

695345

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

768083

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

775052

FUS
RNA-binding protein FUS

1

1

High-throughput

0.437

High

1095547

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

1095553

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1095560

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.437

High

1095572

TF3B
Transcription factor IIIB 90 kDa subunit

1

1

Small-scale

0.437

High

1095575

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1095576

VP33A
Vacuolar protein sorting-associated protein 33A

1

3

High-throughput

0.437

High

1095577

PF21A
PHD finger protein 21A

1

7

High-throughput

0.437

High

1095602

RCOR1
REST corepressor 1

1

2

High-throughput

0.437

High

653287

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.407

High

669166

ADA1D
Alpha-1D adrenergic receptor

1

2

Small-scale

0.407

High

1095540

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

1

High-throughput

0.407

High

1095555

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.407

High

1095584

PHAF1
Phagosome assembly factor 1

4

0

High-throughput

0.360

High

1095558

CP4X1
Cytochrome P450 4X1

3

0

High-throughput

0.342

High

617691

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.279

Low

1095579

CC120
Coiled-coil domain-containing protein 120

1

0

High-throughput

0.279

Low

1095568

CAGE1
Cancer-associated gene 1 protein

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025