HitPredict

Interactor 1: STAM2 (O75886)
Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)
Gene: STAM2

Interactor 2: UBP8 (P40818)
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
Gene: USP8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.689

Property	Details
Experiments	13129930, 10982817, 29604273, 20736164
Identification Methods	unspecified method, pull down, affinity chromatography technology, protein complementation assay
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 525 Hs			1 1118
+	Mm
		292345 STAM2_MOUSE (1-525): 3.68e-132: 395: 85.14		UBP8_MOUSE (1-1118): 0: 785: 81.04
+	Hs
		777061 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		UBP8_HUMAN (1-1118): 0: 830: 100.00
+	Hs
		275176 GRAP2_HUMAN (175-256): 5.08e-13: 72: 41.46		UBP8_HUMAN (1-1118): 0: 830: 100.00
+	Hs
		777028 GRB2_HUMAN (207-262): 4.5e-12: 67.4: 52.63		UBP8_HUMAN (1-1118): 0: 830: 100.00
+	Mm
		292688 GRAP2_MOUSE (175-256): 1.61e-12: 70.5: 40.24		UBP8_MOUSE (1-1118): 0: 785: 81.04
+	Mm
		1141140 GRB2_MOUSE (207-262): 4.58e-12: 67.4: 52.63		UBP8_MOUSE (1-1118): 0: 785: 81.04
+	Hs
		1045412 SPTN1_HUMAN (103-481): 2.5e-55: 202: 14.59		UBP10_HUMAN (388-1110): 2.96e-101: 340: 17.99
+	Hs
		1270632 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		UBP15_HUMAN (964-1106): 1.96e-34: 145: 49.65
+	Hs
		259274 GRB2_HUMAN (207-262): 4.5e-12: 67.4: 52.63		UBP12_HUMAN (767-1110): 2.83e-106: 339: 27.70
+	Dm
		1280443 HRS_DROME (7-145): 1.94e-41: 160: 28.06		Q9VDD8_DROME (9-660): 1.72e-64: 238: 20.63