Protein: CHLE
Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)

Gene: CHLE, BCHE
Organism: Homo sapiens
Interactions: 72
UniProt ID: P06276

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0003824 - catalytic activity
GO:0003990 - acetylcholinesterase activity
GO:0004104 - cholinesterase activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

441403

CHLE
Cholinesterase

5

14

Small-scale

0.927

High

441428

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

4

High-throughput

0.861

High

441444

PALLD
Palladin

2

0

High-throughput

0.770

High

441408

PGFRA
Platelet-derived growth factor receptor alpha

1

2

High-throughput

0.691

High

441456

FBX2
F-box only protein 2

3

1

High-throughput

0.662

High

441457

COLQ
Acetylcholinesterase collagenic tail peptide

3

3

Small-scale

0.662

High

277063

ENTP5
Nucleoside diphosphate phosphatase ENTPD5

3

0

High-throughput

0.634

High

441422

LOXL1
Lysyl oxidase homolog 1

3

0

High-throughput

0.634

High

133625

WASL
Actin nucleation-promoting factor WASL

2

1

High-throughput

0.628

High

351648

SG1D1
Secretoglobin family 1D member 1

2

1

High-throughput

0.628

High

441426

LTBP1
Latent-transforming growth factor beta-binding protein 1

2

5

High-throughput

0.628

High

441435

SG1D4
Secretoglobin family 1D member 4

2

1

High-throughput

0.628

High

441440

ENAH
Protein enabled homolog

2

2

High-throughput

0.628

High

441416

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.602

High

441421

ACTN3
Alpha-actinin-3

2

0

High-throughput

0.602

High

441423

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.602

High

441455

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

2

0

High-throughput

0.602

High

391785

SMR3B
Submaxillary gland androgen-regulated protein 3B

2

0

High-throughput

0.595

High

441411

CD80
T-lymphocyte activation antigen CD80

1

1

High-throughput

0.575

High

441429

SF01
Splicing factor 1

2

1

High-throughput

0.574

High

441452

DIAP3
Protein diaphanous homolog 3

2

1

High-throughput

0.574

High

441445

TRI63
E3 ubiquitin-protein ligase TRIM63

1

2

High-throughput

0.541

High

286518

SG2A1
Mammaglobin-B

1

1

High-throughput

0.536

High

416585

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

1

High-throughput

0.536

High

441409

CALX
Calnexin

1

1

High-throughput

0.536

High

441410

CYTD
Cystatin-D

1

1

High-throughput

0.536

High

441424

SLAF1
Signaling lymphocytic activation molecule

1

6

High-throughput

0.536

High

441425

SG2A2
Mammaglobin-A

1

1

High-throughput

0.536

High

441432

NMS
Neuromedin-S

1

1

High-throughput

0.536

High

441438

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

2

High-throughput

0.536

High

441448

C1QT7
Complement C1q tumor necrosis factor-related protein 7

1

3

High-throughput

0.536

High

441458

HYOU1
Hypoxia up-regulated protein 1

1

1

High-throughput

0.536

High

316649

LY6H
Lymphocyte antigen 6H

1

0

High-throughput

0.513

High

441405

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.513

High

441406

CCL3
C-C motif chemokine 3

1

0

High-throughput

0.513

High

441414

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.513

High

441417

LCN6
Epididymal-specific lipocalin-6

1

0

High-throughput

0.513

High

441420

NDP
Norrin

1

0

High-throughput

0.513

High

441427

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

0

High-throughput

0.513

High

441434

ISM2
Isthmin-2

1

0

High-throughput

0.513

High

441437

GKN2
Gastrokine-2

1

0

High-throughput

0.513

High

441442

SG1C1
Secretoglobin family 1C member 1

1

0

High-throughput

0.513

High

441443

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.513

High

441454

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

0

High-throughput

0.513

High

441459

ST14
Suppressor of tumorigenicity 14 protein

1

0

High-throughput

0.513

High

441449

TRI55
Tripartite motif-containing protein 55

1

3

High-throughput

0.494

High

167214

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

441407

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

441413

ATX3
Ataxin-3

1

0

High-throughput

0.493

High

441430

CCDC6
Coiled-coil domain-containing protein 6

1

1

High-throughput

0.489

High

280460

PR40A
Pre-mRNA-processing factor 40 homolog A

1

1

High-throughput

0.470

High

441412

BAG6
Large proline-rich protein BAG6

1

2

High-throughput

0.470

High

441404

MDR1
ATP-dependent translocase ABCB1

1

0

High-throughput

0.458

High

441441

COMA1

1

1

High-throughput

0.445

High

441436

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

441451

FBX6
F-box only protein 6

1

1

High-throughput

0.437

High

222243

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.426

High

441431

DB109
Beta-defensin 109B

1

0

High-throughput

0.426

High

49281

SHOT1
Shootin-1

2

0

High-throughput

0.328

High

257715

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

2

0

High-throughput

0.328

High

441433

MANEL
Glycoprotein endo-alpha-1,2-mannosidase-like protein

2

0

High-throughput

0.328

High

441446

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

2

0

High-throughput

0.328

High

441450

NOP10
H/ACA ribonucleoprotein complex subunit 3

2

0

High-throughput

0.328

High

441419

SC11A
Signal peptidase complex catalytic subunit SEC11A

2

0

High-throughput

0.316

High

441439

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

0

High-throughput

0.279

Low

441453

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

0

High-throughput

0.279

Low

441460

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.279

Low

274439

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.268

Low

441415

CASP6
Caspase-6

1

0

High-throughput

0.268

Low

441418

RAN
GTP-binding nuclear protein Ran

1

0

High-throughput

0.268

Low

441447

MIA2
Melanoma inhibitory activity protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025