HitPredict

Interactor 1: STAM2 (O75886)
Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)
Gene: STAM2

Interactor 2: PTN23 (Q9H3S7)
Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14)
Gene: PTPN23

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	26866605, 23477725, 34761192
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, proximity labelling technology
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0043231 - intracellular membrane-bounded organelle GO:0043328 - protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 525 Hs			1 1636
+	Hs
		1270618 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		PTN23_HUMAN (1-1636): 0: 1052: 100.00
+	Hs
		1173028 TM1L2_HUMAN (1-466): 2.13e-88: 282: 17.19		PTN23_HUMAN (1-1636): 0: 1052: 100.00
+	Hs
		241197 TOM1_HUMAN (1-444): 1.01e-80: 262: 17.68		PTN23_HUMAN (1-1636): 0: 1052: 100.00
+	Hs
		1078907 ITSN1_HUMAN (188-414): 1.91e-46: 176: 22.50		PTN23_HUMAN (1-1636): 0: 1052: 100.00
+	Hs
		160187 HGS_HUMAN (135-518): 7.87e-15: 79.4: 10.95		PTN23_HUMAN (1-1636): 0: 1052: 100.00
+	Hs
		275227 GRAP2_HUMAN (175-256): 5.08e-13: 72: 41.46		PTN23_HUMAN (1-1636): 0: 1052: 100.00
+	Mm
		292687 GRAP2_MOUSE (175-256): 1.61e-12: 70.5: 40.24		PTN23_MOUSE (1-1636): 0: 996: 87.33
+	Hs
		1260371 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		PDC6I_HUMAN (9-871): 7.58e-165: 523: 22.24
+	Hs
		277001 STAM2_HUMAN (1-525): 4.7e-141: 418: 100.00		PTN1_HUMAN (1206-1566): 2.6e-121: 390: 26.39
+	Hs
		1078881 ITSN1_HUMAN (188-414): 1.91e-46: 176: 22.50		PDC6I_HUMAN (9-871): 7.58e-165: 523: 22.24
+	Mm
		1141174 GRB2_MOUSE (207-262): 4.58e-12: 67.4: 52.63		PDC6I_MOUSE (9-871): 1.47e-162: 517: 22.77
+	Hs
		573654 GRB2_HUMAN (207-262): 4.5e-12: 67.4: 52.63		PTN1_HUMAN (1206-1566): 2.6e-121: 390: 26.39
+	Dm
		1280452 HRS_DROME (7-145): 1.94e-41: 160: 28.06		Q9VUH6_DROME (254-1486): 4.08e-59: 227: 13.48
+	Mm
		574006 GRB2_MOUSE (207-262): 4.58e-12: 67.4: 52.63		PTPRA_MOUSE (1205-1455): 8.37e-89: 311: 30.59
+	Hs
		577009 GRB2_HUMAN (207-262): 4.5e-12: 67.4: 52.63		PTPRA_HUMAN (1205-1455): 7.92e-89: 310: 30.59
+	Hs
		617047 GRB2_HUMAN (207-262): 4.5e-12: 67.4: 52.63		PTPRE_HUMAN (1208-1453): 1.74e-80: 283: 32.55
+	Mm
		719322 ITSN1_MOUSE (188-395): 1.47e-46: 176: 23.85		PTN11_MOUSE (1195-1459): 4.76e-30: 129: 30.63
+	Hs
		146925 GRB2_HUMAN (207-262): 4.5e-12: 67.4: 52.63		PTPRT_HUMAN (1177-1455): 1.05e-54: 212: 22.73
+	Mm
		719305 GRB2_MOUSE (207-262): 4.58e-12: 67.4: 52.63		PTN11_MOUSE (1195-1459): 4.76e-30: 129: 30.63
+	Rn
		783504 GRB2_RAT (207-262): 4.5e-12: 67.4: 52.63		PTN11_RAT (1195-1459): 6.28e-30: 129: 31.47