HitPredict

Interactor 1: PAK3 (O75914)
Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3)
Gene: PAK3

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 1.00 0.900

The method score is based on:

Property Details
Experiments 15824104, 20936779, 11157984, 10866202
Identification Methods affinity chromatography technology, two hybrid, pull down, two hybrid pooling approach, far western blotting
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PBD~Ras, Pkinase~Ras
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0032956 - regulation of actin cytoskeleton organization
GO:0060997 - dendritic spine morphogenesis
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 559
Hs

1 191
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024