Protein: PTSS2
Phosphatidylserine synthase 2 (PSS-2) (PtdSer synthase 2) (EC 2.7.8.29) (Serine-exchange enzyme II)

Gene: PTSS2, PTDSS2
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q9BVG9

Gene Ontology (top 5):
GO:0003882 - CDP-diacylglycerol-serine O-phosphatidyltransferase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0006659 - phosphatidylserine biosynthetic process
GO:0016020 - membrane
GO:0016740 - transferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

182754

GP182
G-protein coupled receptor 182

2

9

High-throughput

0.601

High

936115

PAR2
Proteinase-activated receptor 2

2

10

High-throughput

0.578

High

1291480

RETR3
Reticulophagy regulator 3

2

0

High-throughput

0.576

High

733062

VIPR1
Vasoactive intestinal polypeptide receptor 1

2

2

High-throughput

0.549

High

771224

APJ
Apelin receptor

2

7

High-throughput

0.549

High

461888

HS90A
Heat shock protein HSP 90-alpha

1

1

High-throughput

0.536

High

468754

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.536

High

483962

HMOX1
Heme oxygenase 1

1

1

High-throughput

0.536

High

669061

FPR2
N-formyl peptide receptor 2

1

12

High-throughput

0.536

High

690365

STOM
Stomatin

1

2

High-throughput

0.536

High

878084

AGRE5
Adhesion G protein-coupled receptor E5

1

1

High-throughput

0.536

High

1106059

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

1

High-throughput

0.536

High

1252872

MBOA1
Membrane-bound glycerophospholipid O-acyltransferase 1

1

1

High-throughput

0.536

High

1407294

CML1
Chemerin-like receptor 1

1

9

High-throughput

0.536

High

1415273

P2Y12
P2Y purinoceptor 12

1

10

High-throughput

0.536

High

1415278

ENTP7
Ectonucleoside triphosphate diphosphohydrolase 7

1

1

High-throughput

0.536

High

1415282

CLC2D
C-type lectin domain family 2 member D

1

1

High-throughput

0.536

High

1415287

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

1

High-throughput

0.536

High

49751

TMM72
Transmembrane protein 72

1

0

High-throughput

0.513

High

125049

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.513

High

336572

PIGN
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.513

High

341472

CDS2
Phosphatidate cytidylyltransferase 2

1

0

High-throughput

0.513

High

344490

STR3N
STARD3 N-terminal-like protein

1

0

High-throughput

0.513

High

845121

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.513

High

1187417

SHSL1
Protein shisa-like-1

1

0

High-throughput

0.513

High

1273279

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.513

High

1324855

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

1350051

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

1363221

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

1382177

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

141862

ACKR2
Atypical chemokine receptor 2

1

7

High-throughput

0.489

High

166032

FFAR1
Free fatty acid receptor 1

1

10

High-throughput

0.489

High

351955

S1PR4
Sphingosine 1-phosphate receptor 4

1

7

High-throughput

0.489

High

355374

B3GT4
Beta-1,3-galactosyltransferase 4

1

1

High-throughput

0.489

High

638238

S1PR1
Sphingosine 1-phosphate receptor 1

1

6

High-throughput

0.489

High

669206

EDNRA
Endothelin-1 receptor

1

3

High-throughput

0.489

High

669247

NK1R
Substance-P receptor

1

2

High-throughput

0.489

High

709278

AA2BR
Adenosine receptor A2b

1

2

High-throughput

0.489

High

771646

DRD3
D(3) dopamine receptor

1

3

High-throughput

0.489

High

820575

GPV
Platelet glycoprotein V

1

1

High-throughput

0.489

High

832447

OPRX
Nociceptin receptor

1

2

High-throughput

0.489

High

833862

P2RY2
P2Y purinoceptor 2

1

10

High-throughput

0.489

High

835375

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

2

High-throughput

0.489

High

868308

P2RY1
P2Y purinoceptor 1

1

10

High-throughput

0.489

High

907052

CCR6
C-C chemokine receptor type 6

1

8

High-throughput

0.489

High

1038690

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

1

High-throughput

0.489

High

1291881

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

10

High-throughput

0.489

High

1366209

LPAR1
Lysophosphatidic acid receptor 1

1

6

High-throughput

0.489

High

1396955

MRGX4
Mas-related G-protein coupled receptor member X4

1

8

High-throughput

0.489

High

1408014

H2A1J
Histone H2A type 1-J

1

1

High-throughput

0.489

High

1413553

H2AJ
Histone H2A.J

1

1

High-throughput

0.489

High

1415272

S22A4
Solute carrier family 22 member 4

1

1

High-throughput

0.489

High

1415275

LPAR2
Lysophosphatidic acid receptor 2

1

7

High-throughput

0.489

High

1415276

GPR35
G-protein coupled receptor 35

1

8

High-throughput

0.489

High

1415279

GP173
Probable G-protein coupled receptor 173

1

4

High-throughput

0.489

High

1415285

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

1

High-throughput

0.489

High

1415286

GPR55
G-protein coupled receptor 55

1

14

High-throughput

0.489

High

1415288

GPR45
Probable G-protein coupled receptor 45

1

4

High-throughput

0.489

High

1203083

TM41B
Transmembrane protein 41B

1

1

High-throughput

0.479

High

1415283

AMFR
E3 ubiquitin-protein ligase AMFR

1

1

High-throughput

0.479

High

1211669

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

0

High-throughput

0.458

High

1249178

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

183961

S22A2
Solute carrier family 22 member 2

1

1

High-throughput

0.445

High

351249

MOT3
Monocarboxylate transporter 3

1

1

High-throughput

0.445

High

1131607

MFS10
Major facilitator superfamily domain-containing protein 10

1

1

High-throughput

0.445

High

1236300

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.445

High

218713

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

831354

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

1162532

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.437

High

1238804

TECT3
Tectonic-3

1

2

High-throughput

0.437

High

1255347

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1276728

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1415271

DUS23
Dual specificity protein phosphatase 23

1

2

High-throughput

0.437

High

256134

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

1175896

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

0

High-throughput

0.426

High

1313988

S35F3
Solute carrier family 35 member F3

1

0

High-throughput

0.426

High

1346773

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

0

High-throughput

0.426

High

1393199

TM169
Transmembrane protein 169

1

0

High-throughput

0.426

High

669359

ACKR3
Atypical chemokine receptor 3

1

9

High-throughput

0.407

High

702838

5HT2C
5-hydroxytryptamine receptor 2C

1

2

High-throughput

0.407

High

704067

5HT1E
5-hydroxytryptamine receptor 1E

1

3

High-throughput

0.407

High

732941

GASR
Gastrin/cholecystokinin type B receptor

1

3

High-throughput

0.407

High

886125

CXCR3
C-X-C chemokine receptor type 3

1

8

High-throughput

0.407

High

907110

CCR9
C-C chemokine receptor type 9

1

8

High-throughput

0.407

High

956998

CXCR4
C-X-C chemokine receptor type 4

1

10

High-throughput

0.407

High

1101650

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

10

High-throughput

0.407

High

1404938

S1PR3
Sphingosine 1-phosphate receptor 3

1

6

High-throughput

0.407

High

260944

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

316433

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

High-throughput

0.279

Low

320496

TM63A
Mechanosensitive cation channel TMEM63A

1

0

High-throughput

0.279

Low

337018

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

High-throughput

0.279

Low

349553

TSN15
Tetraspanin-15

1

0

High-throughput

0.279

Low

469539

SYPH
Synaptophysin

1

0

High-throughput

0.279

Low

749268

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

1251681

T184A
Transmembrane protein 184A

1

0

High-throughput

0.279

Low

1390870

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.279

Low

1415274

RPAP3
RNA polymerase II-associated protein 3

1

0

High-throughput

0.279

Low

1415281

P2RX2
P2X purinoceptor 2

1

0

High-throughput

0.279

Low

1415284

NUDC
Nuclear migration protein nudC

1

0

High-throughput

0.279

Low

294275

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

414536

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

1415280

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1391457

S35A4
Probable UDP-sugar transporter protein SLC35A4

1

0

High-throughput

0.232

Low

1415277

S35C2
Solute carrier family 35 member C2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025