HitPredict

Interactor 1: PIAS1 (O75925)
E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)
Gene: PIAS1

Interactor 2: SLX4 (Q8IY92)
Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Gene: SLX4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	34187905, 37071664, 37059091
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 651 Hs			1 1834
+	Hs
		1222664 PIAS3_HUMAN (1-651): 0: 740: 56.88		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Hs
		1222465 PIAS4_HUMAN (2-423): 0: 550: 51.42		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Hs
		1222475 ZMIZ2_HUMAN (64-423): 3.94e-88: 296: 23.04		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Hs
		278083 PIAS1_HUMAN (1-651): 0: 874: 100.00		MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54
+	Hs
		278139 PIAS1_HUMAN (1-651): 0: 874: 100.00		CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57
+	Hs
		1270855 PIAS3_HUMAN (1-651): 0: 740: 56.88		CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57
+	Hs
		278313 PIAS2_HUMAN (1-566): 0: 633: 58.97		CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57
+	Hs
		1056886 PIAS4_HUMAN (2-423): 0: 550: 51.42		MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54