Protein: PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide]

Gene: PGBM, HSPG2
Organism: Homo sapiens
Interactions: 96
UniProt ID: P98160

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001540 - amyloid-beta binding
GO:0001666 - response to hypoxia
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0005509 - calcium ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

778052

VGFR2
Vascular endothelial growth factor receptor 2

2

11

Small-scale

0.831

High

389290

FINC
Fibronectin

2

17

Small-scale

0.799

High

426950

FGF1
Fibroblast growth factor 1

2

7

Small-scale

0.789

High

1022247

FBLN2
Fibulin-2

2

19

Small-scale

0.778

High

1022553

CAMKV
CaM kinase-like vesicle-associated protein

2

3

High-throughput

0.776

High

478462

FGF2
Fibroblast growth factor 2

2

7

Small-scale

0.768

High

640748

FGF7
Fibroblast growth factor 7

1

7

Small-scale

0.740

High

193548

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

2

High-throughput

0.737

High

609985

VGFR1
Vascular endothelial growth factor receptor 1

1

9

Small-scale

0.730

High

472396

FGF4
Fibroblast growth factor 4

1

7

High-throughput

0.691

High

567830

PRG2
Bone marrow proteoglycan

1

10

High-throughput

0.691

High

945930

LOXL3
Lysyl oxidase homolog 3

1

6

High-throughput

0.691

High

1005524

GPC5
Glypican-5 [Cleaved into: Secreted glypican-5]

1

3

High-throughput

0.691

High

1022551

FNDC5
Fibronectin type III domain-containing protein 5

1

4

High-throughput

0.691

High

1022565

SIRPD
Signal-regulatory protein delta

1

1

High-throughput

0.691

High

1022563

TINAL
Tubulointerstitial nephritis antigen-like

3

1

High-throughput

0.667

High

705308

GRN
Progranulin

3

1

Small-scale

0.661

High

376383

PDGFB
Platelet-derived growth factor subunit B

1

2

Small-scale

0.647

High

403067

PDGFA
Platelet-derived growth factor subunit A

1

2

Small-scale

0.647

High

562712

BMP1
Bone morphogenetic protein 1

1

4

Small-scale

0.647

High

571190

HGF
Hepatocyte growth factor

1

6

Small-scale

0.647

High

585449

VEGFA
Vascular endothelial growth factor A, long form

1

2

Small-scale

0.647

High

673763

LAMA1
Laminin subunit alpha-1

1

17

Small-scale

0.647

High

908626

PRELP
Prolargin

1

7

Small-scale

0.647

High

1022538

NID2
Nidogen-2

1

12

Small-scale

0.647

High

1022540

LTBP2
Latent-transforming growth factor beta-binding protein 2

1

16

Small-scale

0.647

High

185087

TELT
Telethonin

1

1

High-throughput

0.625

High

1022569

FBX6
F-box only protein 6

4

14

High-throughput

0.623

High

541438

FGFR1
Fibroblast growth factor receptor 1

1

7

Small-scale

0.618

High

650128

FGFR3
Fibroblast growth factor receptor 3

1

8

Small-scale

0.618

High

279341

TULP3
Tubby-related protein 3

2

2

High-throughput

0.601

High

519601

LYAG
Lysosomal alpha-glucosidase

2

2

High-throughput

0.601

High

1022545

BRID5
BRICHOS domain-containing protein 5

2

1

High-throughput

0.601

High

1022572

FBX2
F-box only protein 2

2

14

High-throughput

0.601

High

1022562

ACE2
Angiotensin-converting enzyme 2

2

2

Small-scale

0.584

High

1022549

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

1

7

High-throughput

0.575

High

1022573

LOXL2
Lysyl oxidase homolog 2

1

6

Small-scale

0.575

High

1022567

ZN408
Zinc finger protein 408

2

2

High-throughput

0.574

High

1022544

IFIX
Pyrin and HIN domain-containing protein 1

2

6

High-throughput

0.558

High

810597

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

10

Small-scale

0.552

High

389814

TTHY
Transthyretin

1

0

Small-scale

0.537

High

224478

PI15
Peptidase inhibitor 15

1

3

High-throughput

0.536

High

248394

GDF9
Growth/differentiation factor 9

1

4

High-throughput

0.536

High

570660

EDN3
Endothelin-3

1

2

High-throughput

0.536

High

647343

IDS
Iduronate 2-sulfatase

1

1

High-throughput

0.536

High

774055

ADDA
Alpha-adducin

1

6

High-throughput

0.536

High

987544

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.536

High

1022534

IL5RA
Interleukin-5 receptor subunit alpha

1

10

High-throughput

0.536

High

1022539

FGFP1
Fibroblast growth factor-binding protein 1

1

0

Small-scale

0.529

High

251147

B4GT4
Beta-1,4-galactosyltransferase 4

1

0

High-throughput

0.513

High

1022559

IL17F
Interleukin-17F

1

0

High-throughput

0.513

High

139699

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

3

High-throughput

0.508

High

1022543

GFI1B
Zinc finger protein Gfi-1b

1

2

High-throughput

0.508

High

461359

HS90A
Heat shock protein HSP 90-alpha

1

5

Small-scale

0.501

High

507838

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.501

High

517526

GLI3
Transcriptional activator GLI3

1

3

High-throughput

0.500

High

257104

CCD22
Coiled-coil domain-containing protein 22

1

8

High-throughput

0.489

High

837556

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.489

High

1022541

KIF7
Kinesin-like protein KIF7

1

4

High-throughput

0.489

High

1022546

FIGLA
Factor in the germline alpha

1

2

High-throughput

0.489

High

1022547

H2BWT
Histone H2B type W-T

1

15

High-throughput

0.489

High

1022550

ZN444
Zinc finger protein 444

1

3

High-throughput

0.489

High

1022568

SDF2L
Stromal cell-derived factor 2-like protein 1

1

4

High-throughput

0.489

High

1022570

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

1

High-throughput

0.489

High

218062

TGON2
Trans-Golgi network integral membrane protein 2

1

15

High-throughput

0.479

High

323981

CSTN1
Calsyntenin-1

1

5

Small-scale

0.479

High

370183

CYTN
Cystatin-SN

1

4

Small-scale

0.479

High

555378

SKI
Ski oncogene

1

2

Small-scale

0.479

High

702180

LYOX
Protein-lysine 6-oxidase

1

4

Small-scale

0.479

High

933257

MFAP2
Microfibrillar-associated protein 2

1

1

Small-scale

0.479

High

1022536

CUL3
Cullin-3

1

16

High-throughput

0.479

High

1022548

CLC14
C-type lectin domain family 14 member A

1

5

Small-scale

0.479

High

1022552

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1022556

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

928259

ATN1
Atrophin-1

1

9

High-throughput

0.464

High

73795

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

20

High-throughput

0.445

High

167443

WNT9A
Protein Wnt-9a

1

1

High-throughput

0.445

High

615176

PACA
Pituitary adenylate cyclase-activating polypeptide

1

1

High-throughput

0.445

High

767166

MERL
Merlin

1

10

High-throughput

0.445

High

1022561

C1QT1
Complement C1q tumor necrosis factor-related protein 1

1

16

High-throughput

0.445

High

105759

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

192484

INSI1
Insulin-induced gene 1 protein

1

1

High-throughput

0.437

High

887973

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.437

High

1022537

CUL4A
Cullin-4A

1

16

High-throughput

0.437

High

1022557

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.437

High

1022558

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

8

High-throughput

0.437

High

1022564

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

6

Small-scale

0.437

High

1022566

WDR76
WD repeat-containing protein 76

1

13

High-throughput

0.437

High

1022571

HERC5
E3 ISG15--protein ligase HERC5

1

4

Small-scale

0.437

High

1022560

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.426

High

215999

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

2

High-throughput

0.407

High

1022535

ECHP
Peroxisomal bifunctional enzyme

1

2

High-throughput

0.407

High

1022554

EOLA1
Protein EOLA1

1

2

High-throughput

0.407

High

1022555

ESR2
Estrogen receptor beta

1

14

High-throughput

0.407

High

353809

PTTG1
Securin

1

0

High-throughput

0.279

Low

1022542

AKIR2
Akirin-2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025