HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: GCR (P04150)
Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)
Gene: NR3C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	31182584, 11117529
Identification Methods	proximity labelling technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 621 Hs			1 777
+	Hs
		277876 PIAS1_HUMAN (1-621): 0: 653: 54.10		GCR_HUMAN (1-777): 0: 933: 100.00
+	Hs
		278206 PIAS2_HUMAN (1-621): 0: 811: 100.00		ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06
+	Hs
		278210 PIAS2_HUMAN (1-621): 0: 811: 100.00		PRGR_HUMAN (232-777): 2.39e-110: 359: 40.00
+	Hs
		278312 PIAS2_HUMAN (1-621): 0: 811: 100.00		ESR2_HUMAN (286-769): 2.89e-107: 339: 21.34
+	Hs
		278213 PIAS2_HUMAN (1-621): 0: 811: 100.00		ANDR_HUMAN (357-777): 2.54e-100: 332: 45.15
+	Hs
		278228 PIAS2_HUMAN (1-621): 0: 811: 100.00		NR4A1_HUMAN (268-762): 5.59e-103: 331: 20.88
+	Hs
		370843 PIAS3_HUMAN (1-621): 0: 666: 55.25		ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06
+	Hs
		277875 PIAS1_HUMAN (1-621): 0: 653: 54.10		ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06
+	Hs
		414536 PIAS3_HUMAN (1-621): 0: 666: 55.25		PRGR_HUMAN (232-777): 2.39e-110: 359: 40.00
+	Hs
		277885 PIAS1_HUMAN (1-621): 0: 653: 54.10		PRGR_HUMAN (232-777): 2.39e-110: 359: 40.00
+	Hs
		1270069 PIAS3_HUMAN (1-621): 0: 666: 55.25		ESR2_HUMAN (286-769): 2.89e-107: 339: 21.34
+	Hs
		487883 PIAS3_HUMAN (1-621): 0: 666: 55.25		ANDR_HUMAN (357-777): 2.54e-100: 332: 45.15
+	Hs
		611538 PIAS3_HUMAN (1-621): 0: 666: 55.25		NR4A1_HUMAN (268-762): 5.59e-103: 331: 20.88
+	Hs
		278138 PIAS1_HUMAN (1-621): 0: 653: 54.10		ESR2_HUMAN (286-769): 2.89e-107: 339: 21.34
+	Hs
		277899 PIAS1_HUMAN (1-621): 0: 653: 54.10		ANDR_HUMAN (357-777): 2.54e-100: 332: 45.15
+	Hs
		277936 PIAS1_HUMAN (1-621): 0: 653: 54.10		NR4A1_HUMAN (268-762): 5.59e-103: 331: 20.88
+	Hs
		277974 PIAS1_HUMAN (1-621): 0: 653: 54.10		HNF4A_HUMAN (397-757): 7.17e-101: 321: 23.42
+	Hs
		278004 PIAS1_HUMAN (1-621): 0: 653: 54.10		NR1H2_HUMAN (339-760): 9.43e-100: 317: 19.06
+	Hs
		278072 PIAS1_HUMAN (1-621): 0: 653: 54.10		NR1H3_HUMAN (346-760): 1.46e-95: 306: 20.84
+	Hs
		487590 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		ANDR_HUMAN (357-777): 2.54e-100: 332: 45.15