Protein: PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

Gene: PTMA
Organism: Homo sapiens
Interactions: 161
UniProt ID: P06454

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006325 - chromatin organization
GO:0006351 - DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

443063

KEAP1
Kelch-like ECH-associated protein 1

6

2

Small-scale

0.738

High

443067

ELAV1
ELAV-like protein 1

5

0

Small-scale

0.672

High

443056

EP300
Histone acetyltransferase p300

2

2

Small-scale

0.629

High

247601

NUPR1
Nuclear protein 1

2

0

Small-scale

0.620

High

442979

ROA1
Heterogeneous nuclear ribonucleoprotein A1

2

3

Small-scale

0.584

High

443002

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

2

3

Small-scale

0.584

High

443022

CCNF
Cyclin-F

2

1

High-throughput

0.584

High

443038

ACTB
Actin, cytoplasmic 1

2

3

Small-scale

0.584

High

443046

ACTC
Actin, alpha cardiac muscle 1

2

3

High-throughput

0.584

High

443072

FTM
Protein fantom

2

3

High-throughput

0.571

High

443088

CBP
CREB-binding protein

1

2

Small-scale

0.561

High

443083

YAF2
YY1-associated factor 2

2

0

High-throughput

0.559

High

443034

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.552

High

443066

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.552

High

443092

PHB2
Prohibitin-2

1

1

Small-scale

0.552

High

443102

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.549

High

443073

RHGBA
Rho GTPase-activating protein 11A

2

0

High-throughput

0.547

High

180662

TIF1A
Transcription intermediary factor 1-alpha

1

2

High-throughput

0.536

High

443012

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.536

High

443024

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

443033

IMA5
Importin subunit alpha-5

1

1

High-throughput

0.536

High

443048

CDK17
Cyclin-dependent kinase 17

1

2

High-throughput

0.536

High

443082

KLHL7
Kelch-like protein 7

1

2

High-throughput

0.536

High

443106

UBQL1
Ubiquilin-1

1

3

High-throughput

0.515

High

187252

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.513

High

442978

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

442986

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

443027

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

High-throughput

0.513

High

443028

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

443044

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.513

High

443047

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.513

High

443058

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.513

High

443074

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

0

High-throughput

0.513

High

443075

CC137
Coiled-coil domain-containing protein 137

1

0

High-throughput

0.513

High

443077

APTX
Aprataxin

1

0

High-throughput

0.513

High

443093

ARI3A
AT-rich interactive domain-containing protein 3A

1

0

High-throughput

0.513

High

443100

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

High-throughput

0.513

High

443101

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.513

High

443107

DDX52
Probable ATP-dependent RNA helicase DDX52

1

0

High-throughput

0.513

High

443029

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.508

High

443020

STAT3
Signal transducer and activator of transcription 3

1

0

Small-scale

0.506

High

443050

SET
Protein SET

1

0

Small-scale

0.506

High

278207

NCOR1
Nuclear receptor corepressor 1

1

2

Small-scale

0.501

High

443057

HDAC1
Histone deacetylase 1

1

1

Small-scale

0.501

High

443087

HDAC2
Histone deacetylase 2

1

1

Small-scale

0.501

High

339632

KLF8
Krueppel-like factor 8

1

1

High-throughput

0.500

High

443095

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.500

High

443108

MTCL1
Microtubule cross-linking factor 1

1

3

High-throughput

0.489

High

395326

ESR1
Estrogen receptor

1

0

Small-scale

0.480

High

443091

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.480

High

250415

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.479

High

324276

ARHGF
Rho guanine nucleotide exchange factor 15

1

1

High-throughput

0.479

High

385217

K2C6A
Keratin, type II cytoskeletal 6A

1

3

Small-scale

0.479

High

407359

K2C1
Keratin, type II cytoskeletal 1

1

2

Small-scale

0.479

High

442974

K1C19
Keratin, type I cytoskeletal 19

1

4

Small-scale

0.479

High

442975

K1C16
Keratin, type I cytoskeletal 16

1

4

Small-scale

0.479

High

442981

BIP
Endoplasmic reticulum chaperone BiP

1

3

Small-scale

0.479

High

442982

HSP7C
Heat shock cognate 71 kDa protein

1

2

Small-scale

0.479

High

442988

K1C10
Keratin, type I cytoskeletal 10

1

5

Small-scale

0.479

High

442989

K2C5
Keratin, type II cytoskeletal 5

1

2

Small-scale

0.479

High

442995

HSP76
Heat shock 70 kDa protein 6

1

2

Small-scale

0.479

High

442997

NELFE
Negative elongation factor E

1

1

High-throughput

0.479

High

443007

PDIA3
Protein disulfide-isomerase A3

1

1

High-throughput

0.479

High

443010

HS71L
Heat shock 70 kDa protein 1-like

1

2

Small-scale

0.479

High

443011

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

443013

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

443014

K1C9
Keratin, type I cytoskeletal 9

1

4

Small-scale

0.479

High

443015

MYH9
Myosin-9

1

2

Small-scale

0.479

High

443016

MYH10
Myosin-10

1

2

Small-scale

0.479

High

443017

K22E
Keratin, type II cytoskeletal 2 epidermal

1

3

Small-scale

0.479

High

443018

SRP14
Signal recognition particle 14 kDa protein

1

1

High-throughput

0.479

High

443019

HSPA9
Stress-70 protein, mitochondrial

1

4

Small-scale

0.479

High

443025

BAG6
Large proline-rich protein BAG6

1

4

High-throughput

0.479

High

443026

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.479

High

443031

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

3

Small-scale

0.479

High

443035

HDAC4
Histone deacetylase 4

1

2

High-throughput

0.479

High

443042

ACTA
Actin, aortic smooth muscle

1

3

High-throughput

0.479

High

443045

ACTG
Actin, cytoplasmic 2

1

3

High-throughput

0.479

High

443055

SRSF4
Serine/arginine-rich splicing factor 4

1

1

High-throughput

0.479

High

443061

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

4

Small-scale

0.479

High

443094

CP250
Centrosome-associated protein CEP250

1

2

High-throughput

0.479

High

443105

TBK1
Serine/threonine-protein kinase TBK1

1

1

High-throughput

0.479

High

136772

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

159467

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

215016

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

0

High-throughput

0.458

High

324413

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

361055

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.458

High

365266

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.458

High

375087

RASK
GTPase KRas

1

0

High-throughput

0.458

High

429146

JUN
Transcription factor Jun

1

0

High-throughput

0.458

High

442972

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

442973

PROF1
Profilin-1

1

0

High-throughput

0.458

High

442977

RET1
Retinol-binding protein 1

1

0

High-throughput

0.458

High

442985

KCRB
Creatine kinase B-type

1

0

High-throughput

0.458

High

442991

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.458

High

442992

ENPL
Endoplasmin

1

0

High-throughput

0.458

High

442994

STMN1
Stathmin

1

0

High-throughput

0.458

High

442996

TAL1
T-cell acute lymphocytic leukemia protein 1

1

0

High-throughput

0.458

High

442999

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.458

High

443000

PTMS
Parathymosin

1

0

High-throughput

0.458

High

443003

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

0

High-throughput

0.458

High

443005

CALR
Calreticulin

1

0

High-throughput

0.458

High

443006

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

443008

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

0

Small-scale

0.458

High

443009

1433B
14-3-3 protein beta/alpha

1

0

Small-scale

0.458

High

443021

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

443023

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

0

Small-scale

0.458

High

443030

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.458

High

443037

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

443039

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

443041

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.458

High

443049

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

443051

ANK2
Ankyrin-2

1

0

High-throughput

0.458

High

443052

MEF2A
Myocyte-specific enhancer factor 2A

1

0

High-throughput

0.458

High

443053

H11
Histone H1.1

1

0

Small-scale

0.458

High

443054

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

443059

CUL3
Cullin-3

1

0

High-throughput

0.458

High

443060

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.458

High

443068

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

443070

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

443071

PAP1M
Polyadenylate-binding protein 1-like 2

1

0

High-throughput

0.458

High

443076

BRWD3
Bromodomain and WD repeat-containing protein 3

1

0

High-throughput

0.458

High

443078

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

443084

SYNE1
Nesprin-1

1

0

High-throughput

0.458

High

443086

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

0

High-throughput

0.458

High

443096

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

443099

RHG39
Rho GTPase-activating protein 39

1

0

High-throughput

0.458

High

443103

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

443104

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

442971

CDK1
Cyclin-dependent kinase 1

1

2

Small-scale

0.445

High

442983

CDK4
Cyclin-dependent kinase 4

1

2

Small-scale

0.445

High

443004

CDK2
Cyclin-dependent kinase 2

1

2

Small-scale

0.445

High

443032

IMA1
Importin subunit alpha-1

1

1

Small-scale

0.445

High

443098

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

443080

ZDH17
Palmitoyltransferase ZDHHC17

1

3

High-throughput

0.439

High

442990

PDIA4
Protein disulfide-isomerase A4

1

1

High-throughput

0.437

High

443079

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.437

High

443109

MYH4
Myosin-4

1

2

High-throughput

0.437

High

442980

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

442984

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.426

High

442993

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.426

High

442998

RCC1
Regulator of chromosome condensation

1

0

Small-scale

0.426

High

443036

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.426

High

443043

RAN
GTP-binding nuclear protein Ran

1

0

Small-scale

0.426

High

443065

IMB1
Importin subunit beta-1

1

0

Small-scale

0.426

High

443089

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

3442

A0A0S2Z547
Rho guanine nucleotide exchange factor 15 isoform 1

1

1

High-throughput

0.407

High

114621

H0YLW0
Signal recognition particle 14

1

1

High-throughput

0.407

High

442976

RM03
Large ribosomal subunit protein uL3m

1

0

High-throughput

0.279

Low

443069

KNOP1
Lysine-rich nucleolar protein 1

1

0

High-throughput

0.279

Low

443090

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

443001

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.268

Low

443064

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

0

High-throughput

0.268

Low

443110

Q9Y649
GW128

1

0

High-throughput

0.268

Low

352844

AGR2
Anterior gradient protein 2 homolog

1

0

Small-scale

0.249

Low

442987

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

0

High-throughput

0.249

Low

443040

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.249

Low

443062

SEPT6
Septin-6

1

0

High-throughput

0.249

Low

443081

SL9A9
Sodium/hydrogen exchanger 9

1

0

Small-scale

0.249

Low

443085

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

High-throughput

0.249

Low

443097

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025