HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 0.60 0.714

The method score is based on:

Property Details
Experiments 19339993, 11867732, 34795231, 38580884, 18624398
Identification Methods enzymatic study, pull down, proximity labelling technology, two hybrid
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0008270 - zinc ion binding
and 3 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 621
Hs

1 393
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
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+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024