HitPredict

Interactor 1: CDKA2 (O75956)
Cyclin-dependent kinase 2-associated protein 2 (CDK2-associated protein 2) (DOC-1-related protein) (DOC-1R)
Gene: CDK2AP2

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	35271311, 33283408, 21258344
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016581 - NuRD complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 488
+	Hs
		146847 CDKA1_HUMAN (11-126): 3.84e-47: 149: 58.97		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		279800 CDKA2_HUMAN (1-126): 1.09e-51: 161: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		146816 CDKA1_HUMAN (11-126): 3.84e-47: 149: 58.97		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Dm
		1276557 Q9VZ27_DROME (31-125): 8.24e-36: 125: 46.32		HDAC1_DROME (5-472): 0: 653: 77.92
+	Dm
		115159 M9PEA2_DROME (31-125): 1.11e-34: 123: 46.32		HDAC1_DROME (5-472): 0: 653: 77.92
+	Hs
		146773 CDKA1_HUMAN (11-126): 3.84e-47: 149: 58.97		HDAC3_HUMAN (10-431): 0: 574: 58.26