Protein: APLP2
Amyloid beta precursor like protein 2 (APPH) (Amyloid beta (A4) precursor-like protein 2) (Amyloid protein homolog) (Amyloid-like protein 2) (APLP-2) (CDEI box-binding protein) (CDEBP) (Sperm membrane protein YWK-II)

Gene: APLP2
Organism: Homo sapiens
Interactions: 130
UniProt ID: Q06481

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005634 - nucleus
GO:0005788 - endoplasmic reticulum lumen
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

120897

APBB1
Amyloid beta precursor protein binding family B member 1

5

15

Small-scale

0.923

High

319411

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

4

15

Small-scale

0.897

High

987529

APBB2
Amyloid beta precursor protein binding family B member 2

4

15

Small-scale

0.895

High

589596

KLK2
Kallikrein-2

3

12

High-throughput

0.861

High

331381

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

3

13

Small-scale

0.858

High

394591

A4
Amyloid-beta precursor protein

2

13

Small-scale

0.806

High

987497

APLP2
Amyloid beta precursor like protein 2

1

14

Small-scale

0.724

High

987560

BTNL2
Butyrophilin-like protein 2

1

6

High-throughput

0.691

High

987565

ST14
Suppressor of tumorigenicity 14 protein

1

15

High-throughput

0.691

High

849928

APLP1
Amyloid beta precursor like protein 1

1

12

Small-scale

0.681

High

987535

PGCB
Brevican core protein

1

10

High-throughput

0.665

High

158926

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

High-throughput

0.656

High

987546

SIRPD
Signal-regulatory protein delta

1

0

High-throughput

0.656

High

269140

DAB1
Disabled homolog 1

1

17

Small-scale

0.647

High

957169

DAB2
Disabled homolog 2

1

16

Small-scale

0.647

High

401885

JUN
Transcription factor Jun

2

6

High-throughput

0.640

High

548691

VAV
Proto-oncogene vav

2

5

High-throughput

0.628

High

987549

KLK15
Kallikrein-15

1

15

High-throughput

0.618

High

566370

KPCA
Protein kinase C alpha type

2

6

Small-scale

0.611

High

570525

PTN2
Tyrosine-protein phosphatase non-receptor type 2

2

4

High-throughput

0.611

High

987539

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

11

High-throughput

0.590

High

350102

RASK
GTPase KRas

2

12

High-throughput

0.584

High

271696

DEDD
Death effector domain-containing protein

1

1

High-throughput

0.578

High

879389

FCGRN
IgG receptor FcRn large subunit p51

2

1

High-throughput

0.574

High

369467

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

542005

ETS1
Protein C-ets-1

1

12

High-throughput

0.561

High

566752

JUNB
Transcription factor JunB

1

6

High-throughput

0.561

High

898604

RL26
Large ribosomal subunit protein uL24

1

2

High-throughput

0.541

High

314310

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

1

High-throughput

0.536

High

396342

APOD
Apolipoprotein D

1

2

High-throughput

0.536

High

474711

CFC1
Cryptic protein

1

3

High-throughput

0.536

High

532934

PRG2
Bone marrow proteoglycan

1

10

High-throughput

0.536

High

550276

CD1E
T-cell surface glycoprotein CD1e, membrane-associated

1

2

High-throughput

0.536

High

898892

PSME3
Proteasome activator complex subunit 3

1

2

High-throughput

0.536

High

987512

DUS5
Dual specificity protein phosphatase 5

1

5

High-throughput

0.536

High

987514

GXLT1
Glucoside xylosyltransferase 1

1

2

High-throughput

0.536

High

987517

BRID5
BRICHOS domain-containing protein 5

1

1

High-throughput

0.536

High

987518

LYPD4
Ly6/PLAUR domain-containing protein 4

1

2

High-throughput

0.536

High

987524

NRSN1
Neurensin-1

1

1

High-throughput

0.536

High

987528

CLC2B
C-type lectin domain family 2 member B

1

11

High-throughput

0.536

High

987532

T106A
Transmembrane protein 106A

1

2

High-throughput

0.536

High

987533

ESPB1
Epididymal sperm-binding protein 1

1

8

High-throughput

0.536

High

987534

MRAP2
Melanocortin-2 receptor accessory protein 2

1

1

High-throughput

0.536

High

987548

CHST8
Carbohydrate sulfotransferase 8

1

1

High-throughput

0.536

High

987553

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.536

High

559669

H12
Histone H1.2

1

3

High-throughput

0.515

High

361479

APOE
Apolipoprotein E

1

4

High-throughput

0.515

High

380768

S100B
Protein S100-B

1

3

High-throughput

0.515

High

412148

FYN
Tyrosine-protein kinase Fyn

1

9

High-throughput

0.515

High

616703

KS6B1
Ribosomal protein S6 kinase beta-1

1

11

High-throughput

0.515

High

796551

KSYK
Tyrosine-protein kinase SYK

1

20

High-throughput

0.515

High

950151

SMAD3
Mothers against decapentaplegic homolog 3

1

3

High-throughput

0.515

High

987508

BLMH
Bleomycin hydrolase

1

1

High-throughput

0.515

High

987510

LRP8
Low-density lipoprotein receptor-related protein 8

1

12

High-throughput

0.515

High

987523

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

5

High-throughput

0.515

High

987541

ERP44
Endoplasmic reticulum resident protein 44

1

7

High-throughput

0.515

High

987544

TM2D1
TM2 domain-containing protein 1

1

2

High-throughput

0.515

High

217161

EXTL3
Exostosin-like 3

1

0

High-throughput

0.513

High

987527

HPSE2
Inactive heparanase-2

1

0

High-throughput

0.513

High

987538

TMM74
Transmembrane protein 74

1

0

High-throughput

0.513

High

987542

TMM43
Transmembrane protein 43

1

0

High-throughput

0.513

High

987551

PROK2
Prokineticin-2

1

0

High-throughput

0.513

High

987556

GINM1
Glycoprotein integral membrane protein 1

1

0

High-throughput

0.513

High

159970

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

5

Small-scale

0.501

High

414884

CDK1
Cyclin-dependent kinase 1

1

5

Small-scale

0.501

High

451007

GNAO

1

6

Small-scale

0.501

High

475657

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.501

High

749409

BRCA1
Breast cancer type 1 susceptibility protein

1

2

Small-scale

0.501

High

800757

MK08
Mitogen-activated protein kinase 8

1

8

Small-scale

0.501

High

987531

MED12
Mediator of RNA polymerase II transcription subunit 12

1

5

Small-scale

0.501

High

987509

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

4

High-throughput

0.500

High

987563

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.500

High

987498

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.493

High

514372

PSPC
Surfactant protein C

1

1

High-throughput

0.489

High

535631

EDN3
Endothelin-3

1

1

High-throughput

0.489

High

573666

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

5

High-throughput

0.489

High

606994

UD14
UDP-glucuronosyltransferase 1A4

1

3

High-throughput

0.489

High

987516

UD3A1
UDP-glucuronosyltransferase 3A1

1

3

High-throughput

0.489

High

987521

SYDE1
Rho GTPase-activating protein SYDE1

1

8

High-throughput

0.489

High

987547

CSTL1
Cystatin-like 1

1

5

High-throughput

0.489

High

987550

UD17
UDP-glucuronosyltransferase 1A7

1

3

High-throughput

0.489

High

987530

KAT5
Histone acetyltransferase KAT5

1

3

Small-scale

0.481

High

987545

S13A1
Solute carrier family 13 member 1

1

1

Small-scale

0.481

High

205305

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

348631

RASN
GTPase NRas

1

14

High-throughput

0.479

High

374100

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

587544

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

4

High-throughput

0.479

High

673790

NKTR
NK-tumor recognition protein

1

4

High-throughput

0.479

High

683984

1433S
14-3-3 protein sigma

1

6

High-throughput

0.479

High

713789

RYK
Tyrosine-protein kinase RYK

1

10

Small-scale

0.479

High

803502

BAG6
Large proline-rich protein BAG6

1

10

Small-scale

0.479

High

814935

LEG7
Galectin-7

1

4

High-throughput

0.479

High

890116

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

984255

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

9

Small-scale

0.479

High

987499

STX4
Syntaxin-4

1

6

High-throughput

0.479

High

987500

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

9

Small-scale

0.479

High

987502

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

9

Small-scale

0.479

High

987505

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

987506

CUL3
Cullin-3

1

6

High-throughput

0.479

High

987513

CAH9
Carbonic anhydrase 9

1

2

High-throughput

0.479

High

987519

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

987525

RN149
E3 ubiquitin-protein ligase RNF149

1

5

High-throughput

0.479

High

987526

RN128
E3 ubiquitin-protein ligase RNF128

1

5

High-throughput

0.479

High

987552

SPON1
Spondin-1

1

8

Small-scale

0.479

High

987558

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.479

High

987559

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

987562

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.479

High

60516

CL18A
C-type lectin domain family 18 member A

1

7

High-throughput

0.470

High

535371

GFAP
Glial fibrillary acidic protein

1

6

High-throughput

0.470

High

987501

STX5
Syntaxin-5

1

9

High-throughput

0.470

High

987504

TCOF
Treacle protein

1

3

High-throughput

0.470

High

987537

MARK4
MAP/microtubule affinity-regulating kinase 4

1

3

High-throughput

0.470

High

987543

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

2

High-throughput

0.470

High

987536

Z512B
Zinc finger protein 512B

1

10

High-throughput

0.464

High

239957

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.445

High

887822

CD81
CD81 antigen

1

3

High-throughput

0.445

High

987507

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.445

High

987554

MED4
Mediator of RNA polymerase II transcription subunit 4

1

2

Small-scale

0.445

High

987515

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.437

High

987520

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

987522

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

2

High-throughput

0.437

High

987561

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.328

High

562160

ANFB
Natriuretic peptides B

1

0

High-throughput

0.279

Low

987503

NOGG
Noggin

1

0

High-throughput

0.279

Low

987511

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

987555

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.279

Low

987557

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

987564

NSG2
Neuronal vesicle trafficking-associated protein 2

1

0

High-throughput

0.279

Low

987540

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.251

Low


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Last updated: 15 Jul 2024