HitPredict

Interactor 1: TRIO (O75962)
Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)
Gene: TRIO

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	22558309
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~RhoGEF, PH~SH3_1, PH~SH3_9, PH_13~RhoGEF, RhoGEF~RhoGEF, RhoGEF~SH3_1, RhoGEF~SH3_9, SH3_1~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 3097 Hs			1 1697
+	Hs
		279824 TRIO_HUMAN (41-3097): 0: 2357: 100.00		TRIO_HUMAN (205-1561): 3.77e-74: 277: 10.84
+	Hs
		279865 TRIO_HUMAN (41-3097): 0: 2357: 100.00		ARHG7_HUMAN (770-1003): 4.21e-12: 73.3: 18.14
+	Mm
		57839 TRIO_MOUSE (1-3097): 0: 2316: 95.75		KALRN_MOUSE (216-869): 7.67e-09: 63.3: 8.32
+	Hs
		1045423 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		963335 SPTB2_HUMAN (61-1626): 2.73e-78: 293: 12.52		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		974160 DYST_HUMAN (442-1367): 1.65e-16: 89.7: 10.25		ITSN2_HUMAN (1-1697): 0: 969: 100.00
+	Hs
		974083 DYST_HUMAN (442-1367): 1.65e-16: 89.7: 10.25		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		224714 SPTN1_HUMAN (186-2165): 3.14e-107: 387: 12.77		KALRN_HUMAN (187-1602): 9.25e-86: 315: 12.48
+	Mm
		57827 SPTN1_MOUSE (186-2165): 7.22e-106: 383: 12.24		KALRN_MOUSE (216-869): 7.67e-09: 63.3: 8.32
+	Hs
		1123274 PKHG4_HUMAN (1288-1598): 2.52e-41: 170: 32.81		FGD2_HUMAN (1173-1587): 2.78e-78: 275: 22.90
+	Mm
		57809 B9EKJ1_MOUSE (186-2165): 7.1e-105: 380: 12.32		KALRN_MOUSE (216-869): 7.67e-09: 63.3: 8.32
+	Mm
		57856 Q68FG2_MOUSE (335-2015): 2.01e-69: 263: 12.08		KALRN_MOUSE (216-869): 7.67e-09: 63.3: 8.32
+	Hs
		1299922 PKH4B_HUMAN (67-379): 6.12e-55: 215: 22.53		ARHGC_HUMAN (1189-1535): 2.93e-21: 103: 27.07
+	Hs
		167107 PKH4B_HUMAN (67-379): 6.12e-55: 215: 22.53		ARHGB_HUMAN (1207-1441): 1.17e-20: 101: 30.08
+	Hs
		1049709 KCC4_HUMAN (2789-3082): 9.99e-45: 172: 36.36		ARHG7_HUMAN (770-1003): 4.21e-12: 73.3: 18.14
+	Mm
		57815 F6Q750_MOUSE (306-1972): 7.28e-42: 173: 10.52		KALRN_MOUSE (216-869): 7.67e-09: 63.3: 8.32
+	Mm
		1142380 MACF1_MOUSE (127-1205): 6.3e-16: 87.8: 10.45		ARHG1_MOUSE (1199-1441): 2.78e-19: 97.1: 30.95
+	Mm
		57853 SPTB2_MOUSE (61-642): 8.64e-21: 103: 11.15		KALRN_MOUSE (216-869): 7.67e-09: 63.3: 8.32
+	Mm
		57861 SESD1_MOUSE (605-1100): 9.24e-19: 95.6: 15.14		KALRN_MOUSE (216-869): 7.67e-09: 63.3: 8.32