HitPredict

Interactor 1: KRT36 (O76013)
Keratin, type I cuticular Ha6 (Hair keratin, type I Ha6) (Keratin-36) (K36)
Gene: KRT36

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 467 Hs			1 217
+	Hs
		924493 K1C17_HUMAN (85-465): 6.17e-149: 433: 56.69		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		359329 K1C14_HUMAN (4-466): 4.36e-147: 429: 49.90		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		444346 K1C19_HUMAN (83-412): 1.62e-143: 418: 59.70		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		445027 K1C16_HUMAN (91-407): 2.02e-122: 367: 62.46		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		580010 K1C15_HUMAN (92-404): 7.3e-123: 367: 62.22		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		280559 KRT34_HUMAN (36-428): 2.7e-113: 340: 69.47		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924576 KRT81_HUMAN (2-412): 6.5e-88: 279: 25.59		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924469 KRT83_HUMAN (3-412): 2.14e-86: 275: 24.94		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		213936 KRT86_HUMAN (2-412): 3.08e-86: 274: 25.59		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924679 K2C73_HUMAN (8-407): 1.28e-83: 269: 22.88		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924741 KRT35_HUMAN (1-404): 1.25e-84: 269: 73.28		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		403444 K1C14_MOUSE (5-466): 3.53e-147: 430: 49.59		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		924574 KT33B_HUMAN (37-435): 8.45e-83: 262: 69.67		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924575 K1H2_HUMAN (1-411): 3e-81: 260: 67.15		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		275168 K1C13_HUMAN (82-444): 9.39e-143: 418: 53.30		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62
+	Mm
		403471 K1C16_MOUSE (92-401): 2.78e-119: 358: 62.26		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		280510 KRT34_HUMAN (36-428): 2.7e-113: 340: 69.47		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		280771 KRT36_HUMAN (1-467): 4.6e-93: 291: 100.00		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		442865 KRT35_HUMAN (1-404): 1.25e-84: 269: 73.28		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		442846 K1C40_HUMAN (6-423): 2.82e-70: 231: 61.01		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39