HitPredict

Interactor 1: RGS20 (O76081)
Regulator of G-protein signaling 20 (RGS20) (Gz-selective GTPase-activating protein) (G(z)GAP) (Gz-GAP) (Regulator of G-protein signaling Z1) (Regulator of Gz-selective protein signaling 1)
Gene: RGS20

Interactor 2: GNAO (P09471)
Guanine nucleotide-binding protein G(o) subunit alpha
Gene: GNAO1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	18407463
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 388 Hs			1 354
+	Hs
		283156 RGS20_HUMAN (1-388): 1.09e-166: 473: 100.00		GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30
+	Hs
		283183 RGS20_HUMAN (1-388): 1.09e-166: 473: 100.00		GNAI1_HUMAN (1-354): 1.98e-170: 480: 72.11
+	Hs
		283162 RGS20_HUMAN (1-388): 1.09e-166: 473: 100.00		GNAZ_HUMAN (1-353): 2.11e-152: 434: 60.45
+	Hs
		926723 RGS17_HUMAN (179-388): 3.06e-70: 221: 61.79		GNAI1_HUMAN (1-354): 1.98e-170: 480: 72.11
+	Hs
		450988 RGS19_HUMAN (161-387): 4.01e-63: 203: 50.88		GNAO_HUMAN (1-354): 3.01e-176: 494: 100.00
+	Hs
		444806 RGS17_HUMAN (179-388): 3.06e-70: 221: 61.79		GNAI3_HUMAN (1-354): 9.79e-168: 473: 71.27
+	Hs
		391356 RGS19_HUMAN (161-387): 4.01e-63: 203: 50.88		GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30
+	Hs
		834879 RGS19_HUMAN (161-387): 4.01e-63: 203: 50.88		GNAI1_HUMAN (1-354): 1.98e-170: 480: 72.11
+	Hs
		391473 RGS18_HUMAN (229-386): 8.29e-61: 198: 39.87		GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30
+	Hs
		926720 RGS18_HUMAN (229-386): 8.29e-61: 198: 39.87		GNAI1_HUMAN (1-354): 1.98e-170: 480: 72.11
+	Hs
		444691 RGS19_HUMAN (161-387): 4.01e-63: 203: 50.88		GNAI3_HUMAN (1-354): 9.79e-168: 473: 71.27
+	Dm
		558476 Q8T017_DROME (170-388): 1.4e-63: 206: 48.42		GNAO_DROME (1-354): 8.23e-166: 468: 82.20
+	Hs
		444693 RGS7_HUMAN (197-384): 5.09e-58: 198: 30.00		GNAI3_HUMAN (1-354): 9.79e-168: 473: 71.27
+	Hs
		444800 RGS18_HUMAN (229-386): 8.29e-61: 198: 39.87		GNAI3_HUMAN (1-354): 9.79e-168: 473: 71.27
+	Hs
		834946 RGS7_HUMAN (197-384): 5.09e-58: 198: 30.00		GNAQ_HUMAN (1-353): 4.44e-161: 456: 50.85
+	Hs
		837653 RGS18_HUMAN (229-386): 8.29e-61: 198: 39.87		GNAQ_HUMAN (1-353): 4.44e-161: 456: 50.85
+	Mm
		597637 RGS18_MOUSE (229-386): 1.38e-59: 194: 39.87		GNAQ_MOUSE (1-353): 2.38e-161: 457: 50.85
+	Bt
		221230 RGS9_BOVIN (196-384): 1e-57: 197: 26.43		GNAT1_BOVIN (1-354): 3.44e-157: 446: 61.97
+	Hs
		580409 RGS19_HUMAN (161-387): 4.01e-63: 203: 50.88		GNAZ_HUMAN (1-353): 2.11e-152: 434: 60.45
+	Hs
		580410 RGS7_HUMAN (197-384): 5.09e-58: 198: 30.00		GNAZ_HUMAN (1-353): 2.11e-152: 434: 60.45