Protein: HDGR2
Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2)

Gene: HDGR2, HDGFL2
Organism: Homo sapiens
Interactions: 207
UniProt ID: Q7Z4V5

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006281 - DNA repair
GO:0006310 - DNA recombination
GO:0006338 - chromatin remodeling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

908415

HDGF
Hepatoma-derived growth factor

3

12

High-throughput

0.847

High

998483

H31
Histone H3.1

3

20

High-throughput

0.827

High

277726

H2AY
Core histone macro-H2A.1

2

20

High-throughput

0.789

High

283113

PSIP1
PC4 and SFRS1-interacting protein

2

13

High-throughput

0.789

High

591712

H2AX
Histone H2AX

2

16

Small-scale

0.789

High

1016981

H33
Histone H3.3

2

20

High-throughput

0.754

High

997825

CSK21
Casein kinase II subunit alpha

5

8

High-throughput

0.718

High

625466

CSK22
Casein kinase II subunit alpha'

5

10

High-throughput

0.716

High

882520

ARRB1
Beta-arrestin-1

4

1

High-throughput

0.694

High

1278821

H2AW
Core histone macro-H2A.2

1

20

High-throughput

0.691

High

1278835

HDGR3
Hepatoma-derived growth factor-related protein 3

1

12

High-throughput

0.691

High

1277165

POGZ
Pogo transposable element with ZNF domain

4

10

Small-scale

0.683

High

1278834

KLH20
Kelch-like protein 20

3

1

High-throughput

0.667

High

1258869

H32
Histone H3.2

1

20

Small-scale

0.666

High

1278782

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.665

High

732634

ARRB2
Beta-arrestin-2

3

1

High-throughput

0.662

High

1278789

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

3

9

High-throughput

0.662

High

260126

BRD4
Bromodomain-containing protein 4

3

20

High-throughput

0.640

High

883593

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

980879

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

355240

ACL6A
Actin-like protein 6A

2

6

High-throughput

0.611

High

478695

HXB5
Homeobox protein Hox-B5

2

8

High-throughput

0.611

High

787669

SPB5
Serpin B5

2

2

High-throughput

0.611

High

871966

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

3

2

High-throughput

0.604

High

1278825

DBF4A
Protein DBF4 homolog A

3

2

High-throughput

0.604

High

132491

CDC7
Cell division cycle 7-related protein kinase

2

6

High-throughput

0.601

High

995108

CSK2B
Casein kinase II subunit beta

2

1

High-throughput

0.601

High

1006146

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

2

2

High-throughput

0.601

High

1278788

CDA7L
Cell division cycle-associated 7-like protein

2

1

High-throughput

0.601

High

1278793

SRPK1
SRSF protein kinase 1

2

8

High-throughput

0.601

High

1278794

IWS1
Protein IWS1 homolog

2

4

High-throughput

0.601

High

1278827

DAXX
Death domain-associated protein 6

2

1

High-throughput

0.601

High

1278822

MBD5
Methyl-CpG-binding domain protein 5

2

0

High-throughput

0.585

High

1278757

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

2

0

High-throughput

0.576

High

1216218

H37
Histone H3-7

1

20

High-throughput

0.575

High

1149919

TERF2
Telomeric repeat-binding factor 2

1

2

High-throughput

0.573

High

396413

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1209327

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

4

High-throughput

0.571

High

1278765

CSK23
Casein kinase II subunit alpha 3

2

8

High-throughput

0.571

High

1278758

ZCHC7
Zinc finger CCHC domain-containing protein 7

2

5

High-throughput

0.558

High

928485

TERF1
Telomeric repeat-binding factor 1

1

2

High-throughput

0.552

High

1278769

VANG1
Vang-like protein 1

2

1

High-throughput

0.549

High

1278772

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

2

2

High-throughput

0.549

High

1278785

NSUN4
5-cytosine rRNA methyltransferase NSUN4

2

2

High-throughput

0.549

High

1278801

RFIP5
Rab11 family-interacting protein 5

2

2

High-throughput

0.549

High

1278831

VANG2
Vang-like protein 2

2

1

High-throughput

0.549

High

835457

5HT2B
5-hydroxytryptamine receptor 2B

1

1

High-throughput

0.541

High

123751

MYO1C
Unconventional myosin-Ic

1

5

High-throughput

0.536

High

219971

XRCC3
DNA repair protein XRCC3

1

2

High-throughput

0.536

High

903191

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

20

High-throughput

0.536

High

1065265

SSRP1
FACT complex subunit SSRP1

1

15

High-throughput

0.536

High

1136250

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.536

High

1165419

TIGD6
Tigger transposable element-derived protein 6

1

2

High-throughput

0.536

High

1241265

TAF2
Transcription initiation factor TFIID subunit 2

1

1

High-throughput

0.536

High

1278767

ARI1B
AT-rich interactive domain-containing protein 1B

1

2

High-throughput

0.536

High

1278771

SMRC2
SWI/SNF complex subunit SMARCC2

1

9

High-throughput

0.536

High

1278776

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

4

High-throughput

0.536

High

1278779

DPF3
Zinc finger protein DPF3

1

20

High-throughput

0.536

High

1278780

SMRC1
SWI/SNF complex subunit SMARCC1

1

4

High-throughput

0.536

High

1278781

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

1

High-throughput

0.536

High

1278783

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

14

High-throughput

0.536

High

1278787

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

1

High-throughput

0.536

High

1278795

PARK7
Parkinson disease protein 7

1

1

High-throughput

0.536

High

1278798

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

2

High-throughput

0.536

High

1278804

CARD9
Caspase recruitment domain-containing protein 9

1

1

High-throughput

0.536

High

1278829

PARP2
Poly [ADP-ribose] polymerase 2

1

12

High-throughput

0.536

High

1278786

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

10

High-throughput

0.515

High

51635

CBAR1
CBY1-interacting BAR domain-containing protein 1

1

0

High-throughput

0.513

High

163451

MEIS2
Homeobox protein Meis2

1

0

High-throughput

0.513

High

879730

MAPK2
MAP kinase-activated protein kinase 2

1

0

High-throughput

0.513

High

1022177

DAB2
Disabled homolog 2

1

0

High-throughput

0.513

High

1036530

ID2
DNA-binding protein inhibitor ID-2

1

0

High-throughput

0.513

High

1191590

RABL6
Rab-like protein 6

1

0

High-throughput

0.513

High

1210722

ZMYM1
Zinc finger MYM-type protein 1

1

0

High-throughput

0.513

High

1278775

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

1278803

TOLIP
Toll-interacting protein

1

0

High-throughput

0.513

High

1278811

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

1278812

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.513

High

1278823

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

1278830

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.513

High

895201

5HT6R
5-hydroxytryptamine receptor 6

1

1

High-throughput

0.494

High

387850

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

2

High-throughput

0.489

High

1144904

RASA2
Ras GTPase-activating protein 2

1

1

High-throughput

0.489

High

1179317

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

2

High-throughput

0.489

High

1208365

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

11

High-throughput

0.489

High

1212191

MPP7
MAGUK p55 subfamily member 7

1

1

High-throughput

0.489

High

1214346

SYT6
Synaptotagmin-6

1

1

High-throughput

0.489

High

1278752

MILR1
Allergin-1

1

1

High-throughput

0.489

High

1278762

SYT2
Synaptotagmin-2

1

1

High-throughput

0.489

High

1278797

SEM3C
Semaphorin-3C

1

3

High-throughput

0.489

High

1278819

FKB11
Peptidyl-prolyl cis-trans isomerase FKBP11

1

2

High-throughput

0.489

High

1278838

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

242134

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

247980

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

274642

DNJB6
DnaJ homolog subfamily B member 6

1

2

High-throughput

0.479

High

298405

DNJC8
DnaJ homolog subfamily C member 8

1

4

High-throughput

0.479

High

302120

CDKL5
Cyclin-dependent kinase-like 5

1

5

High-throughput

0.479

High

302566

RNF8
E3 ubiquitin-protein ligase RNF8

1

5

Small-scale

0.479

High

316618

ST17B
Serine/threonine-protein kinase 17B

1

7

High-throughput

0.479

High

340356

YETS4
YEATS domain-containing protein 4

1

2

High-throughput

0.479

High

385900

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

13

High-throughput

0.479

High

406329

MYCN
N-myc proto-oncogene protein

1

13

High-throughput

0.479

High

487472

PARP1
Poly [ADP-ribose] polymerase 1

1

20

High-throughput

0.479

High

558233

XRCC6
X-ray repair cross-complementing protein 6

1

10

High-throughput

0.479

High

568153

PLSL
Plastin-2

1

4

High-throughput

0.479

High

606881

CEBPB
CCAAT/enhancer-binding protein beta

1

11

High-throughput

0.479

High

620446

NUCL
Nucleolin

1

7

High-throughput

0.479

High

650829

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

5

High-throughput

0.479

High

674223

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

686235

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.479

High

697159

APEX1
DNA repair nuclease/redox regulator APEX1

1

9

High-throughput

0.479

High

768531

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

785257

RL4
Large ribosomal subunit protein uL4

1

3

High-throughput

0.479

High

897323

CDK7
Cyclin-dependent kinase 7

1

2

High-throughput

0.479

High

929985

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

965058

WDR5
WD repeat-containing protein 5

1

9

High-throughput

0.479

High

970710

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

979896

H4
Histone H4

1

10

High-throughput

0.479

High

986529

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

7

High-throughput

0.479

High

995666

ACTC
Actin, alpha cardiac muscle 1

1

4

High-throughput

0.479

High

1013801

RL24
Large ribosomal subunit protein eL24

1

2

High-throughput

0.479

High

1014141

CBX1
Chromobox protein homolog 1

1

20

Small-scale

0.479

High

1033040

EWS
RNA-binding protein EWS

1

5

High-throughput

0.479

High

1047038

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

1

High-throughput

0.479

High

1097387

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

1100619

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

1

High-throughput

0.479

High

1132788

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

19

High-throughput

0.479

High

1138352

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

1155501

EZH2
Histone-lysine N-methyltransferase EZH2

1

10

High-throughput

0.479

High

1254421

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

1278754

NAA40
N-alpha-acetyltransferase 40

1

5

High-throughput

0.479

High

1278756

SMC5
Structural maintenance of chromosomes protein 5

1

13

High-throughput

0.479

High

1278766

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1278773

DUS19
Dual specificity protein phosphatase 19

1

1

High-throughput

0.479

High

1278777

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1278784

FBXW7
F-box/WD repeat-containing protein 7

1

7

High-throughput

0.479

High

1278796

CTIP
DNA endonuclease RBBP8

1

2

Small-scale

0.479

High

1278800

DDX23
Probable ATP-dependent RNA helicase DDX23

1

5

High-throughput

0.479

High

1278805

ADNP
Activity-dependent neuroprotector homeobox protein

1

2

High-throughput

0.479

High

1278806

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

1278816

DJC17
DnaJ homolog subfamily C member 17

1

3

High-throughput

0.479

High

1278826

ST17A
Serine/threonine-protein kinase 17A

1

6

High-throughput

0.479

High

1278828

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1278832

FBW1A
F-box/WD repeat-containing protein 1A

1

7

High-throughput

0.479

High

128266

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

High-throughput

0.458

High

881226

FAS
Fatty acid synthase

1

0

High-throughput

0.458

High

1278755

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.458

High

1278763

CC020
Uncharacterized protein C3orf20

1

0

High-throughput

0.458

High

1278799

IER2
Immediate early response gene 2 protein

1

0

High-throughput

0.458

High

1278810

SPC25
Kinetochore protein Spc25

1

0

High-throughput

0.458

High

1278814

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1278817

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1278820

DJC27
DnaJ homolog subfamily C member 27

1

0

High-throughput

0.458

High

285683

BAF
Barrier-to-autointegration factor

1

1

High-throughput

0.445

High

321583

PRP6
Pre-mRNA-processing factor 6

1

3

High-throughput

0.445

High

346738

CAVN2
Caveolae-associated protein 2

1

2

High-throughput

0.445

High

604689

UBF1
Nucleolar transcription factor 1

1

16

High-throughput

0.445

High

622831

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

5

High-throughput

0.445

High

799956

COIL
Coilin

1

5

High-throughput

0.445

High

846762

GRK6
G protein-coupled receptor kinase 6

1

5

High-throughput

0.445

High

889136

RBM25
RNA-binding protein 25

1

7

High-throughput

0.445

High

1109159

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

5

High-throughput

0.445

High

1204836

DDX6L
Probable ATP-dependent RNA helicase DDX60-like

1

7

High-throughput

0.445

High

1245803

ATAD2
ATPase family AAA domain-containing protein 2

1

3

High-throughput

0.445

High

1247942

ANR11
Ankyrin repeat domain-containing protein 11

1

3

High-throughput

0.445

High

1278759

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

1278768

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

1

High-throughput

0.445

High

1278770

WDR48
WD repeat-containing protein 48

1

10

High-throughput

0.445

High

1278837

SP16H
FACT complex subunit SPT16

1

3

High-throughput

0.445

High

157555

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.437

High

412174

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.437

High

948156

DJB13
DnaJ homolog subfamily B member 13

1

1

High-throughput

0.437

High

1235454

IFIX
Pyrin and HIN domain-containing protein 1

1

7

High-throughput

0.437

High

1278790

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

2

High-throughput

0.437

High

1278807

DJC18
DnaJ homolog subfamily C member 18

1

3

High-throughput

0.437

High

1278815

DJC11
DnaJ homolog subfamily C member 11

1

3

High-throughput

0.437

High

1278833

DJC16
DnaJ homolog subfamily C member 16

1

2

High-throughput

0.437

High

744671

TF2H1
General transcription factor IIH subunit 1

1

0

High-throughput

0.426

High

892587

DNLI3
DNA ligase 3

1

0

High-throughput

0.426

High

1034016

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

1118843

TF2H3
General transcription factor IIH subunit 3

1

0

High-throughput

0.426

High

1278778

TF2H4
General transcription factor IIH subunit 4

1

0

High-throughput

0.426

High

280692

PR40A
Pre-mRNA-processing factor 40 homolog A

1

8

High-throughput

0.407

High

1278753

MTEF4
Transcription termination factor 4, mitochondrial

1

1

High-throughput

0.407

High

1278764

EHBP1
EH domain-binding protein 1

1

1

High-throughput

0.407

High

1278774

SNX33
Sorting nexin-33

1

3

High-throughput

0.407

High

1278792

SNX18
Sorting nexin-18

1

3

High-throughput

0.407

High

1278808

GHC1
Mitochondrial glutamate carrier 1

1

1

High-throughput

0.407

High

1278836

HBS1L
HBS1-like protein

1

1

High-throughput

0.407

High

708984

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.328

High

1030320

AMPD2
AMP deaminase 2

2

0

High-throughput

0.313

High

720679

AGTR1
Type-1 angiotensin II receptor

1

0

High-throughput

0.282

High

287459

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.279

Low

1278760

MESH1
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

1

0

High-throughput

0.279

Low

1278761

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

1278791

F218A
Protein FAM218A

1

0

High-throughput

0.279

Low

1278802

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.279

Low

566733

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.269

Low

178644

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.249

Low

590918

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

687832

SYVC
Valine--tRNA ligase

1

0

High-throughput

0.249

Low

1235242

PTCRA
Pre T-cell antigen receptor alpha

1

0

High-throughput

0.249

Low

1278809

PLRKT
Plasminogen receptor

1

0

High-throughput

0.249

Low

1278813

RTN4
Reticulon-4

1

0

High-throughput

0.249

Low

1278818

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

762344

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.232

Low

1278824

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025