Interactor 1: ARI2 (O76924)
Potential E3 ubiquitin-protein ligase ariadne-2 (EC 2.3.2.31) (Protein ariadne-2) (RING-type E3 ubiquitin transferase ariadne-2)
Gene: ari-2

Interactor 2: PRKN (Q7KTX7)
E3 ubiquitin-protein ligase parkin (EC 2.3.2.31)
Gene: park

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 29689197
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Ariadne~ubiquitin, IBR~ubiquitin, IBR~zf-RING_12, IBR~zf-RING_14
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
and 4 others

more...

Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 509
Dm

1 482
+ Dm
+ Hs
+ Hs
+ Dm
+ Hs
+ Dm
+ Hs
+ At
+ Zm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024