Interactor 1: DNM3A (O88508)
DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA)
Gene: Dnmt3a
Interactor 2: DNM3L (Q9CWR8)
DNA (cytosine-5)-methyltransferase 3-like
Gene: Dnmt3l
Species: Mus musculus
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.86 | 1.00 | 0.932 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 20211142, 16999741, 17713477, 17687327, 24074865 |
| Identification Methods | two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation, molecular sieving, x-ray crystallography, anti bait coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | ADD_DNMT3~ADD_DNMT3 |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000792 - heterochromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 8 others more... |
| Homologous interactions | 8 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
