HitPredict

Interactor 1: NEMO (O88522)
NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: Ikbkg

Interactor 2: IKBA (Q9Z1E3)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha)
Gene: Nfkbia

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.917

Property	Details
Experiments	17158449, 10748240, 11009421, 19091594, 23951545
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Ank_2~CC2-LZ
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0007249 - canonical NF-kappaB signal transduction GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Mm			1 314
+	Bt
		1259265 NEMO_BOVIN (1-412): 1.02e-70: 230: 82.82		Q8WNW7_BOVIN (1-314): 2.4e-82: 253: 92.68
+	Hs
		639834 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		IKBA_HUMAN (1-314): 4.98e-78: 242: 91.17
+	Mm
		291818 NEMO_MOUSE (1-412): 2.4e-74: 239: 100.00		IKBZ_MOUSE (43-301): 2.06e-60: 206: 25.43
+	Hs
		961453 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		NFKB2_HUMAN (68-294): 2.85e-63: 216: 33.48
+	Hs
		1216521 OPTN_HUMAN (67-411): 1.74e-36: 142: 26.40		ZDH17_HUMAN (45-293): 1.48e-58: 200: 25.50
+	Hs
		121608 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		IKBE_HUMAN (30-220): 8.64e-22: 97: 22.22
+	Hs
		862142 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		DAPK1_HUMAN (164-311): 6.25e-21: 95.3: 12.75
+	Mm
		291802 NEMO_MOUSE (1-412): 2.4e-74: 239: 100.00		IKBB_MOUSE (139-275): 5.78e-13: 70.4: 20.11
+	Hs
		1076400 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		IKBB_HUMAN (139-275): 1.75e-14: 75: 20.11
+	Hs
		883695 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		RIPK4_HUMAN (187-314): 1.9e-13: 72.9: 14.84
+	Hs
		1330909 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		Q9H4D1_HUMAN (187-314): 2.68e-13: 72.2: 14.84
+	Hs
		587763 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		NFKB1_HUMAN (21-157): 4.13e-13: 72: 24.31
+	Hs
		1078859 ITSN1_HUMAN (12-368): 5e-36: 142: 15.31		MIB1_HUMAN (29-306): 1.22e-38: 147: 20.50
+	Hs
		1216417 MY18B_HUMAN (35-384): 4.83e-35: 139: 14.54		TNKS2_HUMAN (1-115): 2.74e-26: 111: 10.26
+	Hs
		862127 MYO5B_HUMAN (61-387): 7.82e-29: 121: 15.54		DAPK1_HUMAN (164-311): 6.25e-21: 95.3: 12.75
+	Hs
		1078921 ITSN1_HUMAN (12-368): 5e-36: 142: 15.31		RAI14_HUMAN (107-252): 3.95e-13: 72: 35.62
+	Hs
		1219814 OPTN_HUMAN (67-411): 1.74e-36: 142: 26.40		ANKH1_HUMAN (1-63): 8.95e-11: 64.8: 6.35
+	Hs
		1268104 MY18A_HUMAN (33-384): 1.23e-29: 123: 17.26		RAI14_HUMAN (107-252): 3.95e-13: 72: 35.62
+	Hs
		1329250 TARA_HUMAN (30-279): 7.09e-27: 115: 19.47		RAI14_HUMAN (107-252): 3.95e-13: 72: 35.62
+	Hs
		257713 ITSN2_HUMAN (2-383): 8.92e-25: 109: 13.69		ANR17_HUMAN (1-63): 6e-12: 68.3: 6.35