HitPredict

Interactor 1: P63 (O88898)
Tumor protein 63 (p63) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L)
Gene: Tp63

Interactor 2: P53 (P02340)
Cellular tumor antigen p53 (Tumor suppressor p53)
Gene: Tp53

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.57 1.00 0.757

The method score is based on:

Property Details
Experiments 20211142, 23251530
Identification Methods two hybrid, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains P53~P53, P53~P53_tetramer, P53_tetramer~P53_tetramer
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
and 20 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 680
Mm

1 390
+ Hs
+ Mm
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+ Mm
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+ Mm
+ Hs
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+ Dr
+ Dr
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024