Protein: PLAK2
PALM2-AKAP2 fusion protein (A-kinase anchor protein 2) (AKAP-2) (AKAP-KL) (Paralemmin A kinase anchor protein) (Paralemmin-2) (Protein kinase A-anchoring protein 2) (PRKA2)

Gene: PLAK2, PALM2AKAP2
Organism: Homo sapiens
Interactions: 96
UniProt ID: Q9Y2D5

Gene Ontology (top 5):
GO:0007015 - actin filament organization
GO:0007178 - cell surface receptor protein serine/threonine kinase signaling pathway
GO:0008104 - intracellular protein localization
GO:0008360 - regulation of cell shape
GO:0016324 - apical plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

605857

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

5

1

Small-scale

0.656

High

725568

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

4

4

High-throughput

0.630

High

531180

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

3

4

High-throughput

0.609

High

953199

ACTB
Actin, cytoplasmic 1

3

2

High-throughput

0.585

High

583032

EZRI
Ezrin

2

4

High-throughput

0.584

High

584600

VAV
Proto-oncogene vav

2

2

High-throughput

0.574

High

1091479

ANK3
Ankyrin-3

3

3

High-throughput

0.569

High

651740

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

2

1

High-throughput

0.558

High

1030715

ANK2
Ankyrin-2

2

3

High-throughput

0.552

High

568867

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

2

4

Small-scale

0.550

High

773090

MYH9
Myosin-9

1

1

High-throughput

0.536

High

863037

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

1

High-throughput

0.536

High

1160809

DREB
Drebrin

1

2

High-throughput

0.536

High

1447570

MYO5C
Unconventional myosin-Vc

1

1

High-throughput

0.536

High

988047

GRB2
Growth factor receptor-bound protein 2

2

6

High-throughput

0.521

High

1242431

RHGBA
Rho GTPase-activating protein 11A

2

1

High-throughput

0.521

High

1308698

FMNL3
Formin-like protein 3

1

0

High-throughput

0.513

High

637798

FLNA
Filamin-A

1

1

High-throughput

0.489

High

1325470

SYNPO
Synaptopodin

1

1

High-throughput

0.489

High

1365625

MY18A
Unconventional myosin-XVIIIa

1

2

High-throughput

0.489

High

1391319

CERS2
Ceramide synthase 2

1

1

High-throughput

0.489

High

1447465

ANLN
Anillin

1

1

High-throughput

0.489

High

1447739

PDLI7
PDZ and LIM domain protein 7

1

1

High-throughput

0.489

High

594146

NCK1
SH2/SH3 adapter protein NCK1

1

4

High-throughput

0.479

High

715852

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

767517

RADI
Radixin

1

3

High-throughput

0.479

High

855811

CRK
Adapter molecule crk

1

5

High-throughput

0.479

High

1253251

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

3

High-throughput

0.479

High

1386638

OPTN
Optineurin

1

5

High-throughput

0.470

High

942967

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.445

High

106880

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

158008

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.437

High

193641

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

2

High-throughput

0.437

High

440249

LCK
Tyrosine-protein kinase Lck

1

3

High-throughput

0.437

High

556433

CADH1
Cadherin-1

1

1

High-throughput

0.437

High

557540

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

High-throughput

0.437

High

896671

VASP
Vasodilator-stimulated phosphoprotein

1

1

High-throughput

0.437

High

977863

ACTA
Actin, aortic smooth muscle

1

2

High-throughput

0.437

High

993392

ACTG
Actin, cytoplasmic 2

1

2

High-throughput

0.437

High

1120517

SCRB2
Lysosome membrane protein 2

1

1

High-throughput

0.437

High

1256158

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1385926

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.437

High

1391675

VMP1
Vacuole membrane protein 1

1

1

High-throughput

0.437

High

1420080

KPCD2
Serine/threonine-protein kinase D2

1

1

High-throughput

0.437

High

1433136

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.437

High

1436569

ECT2
Protein ECT2

1

2

High-throughput

0.437

High

1459532

TES
Testin

1

1

High-throughput

0.437

High

1103458

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.407

High

1235040

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.407

High

1217698

SYDE2
Rho GTPase-activating protein SYDE2

2

0

High-throughput

0.298

High

136174

SYT5
Synaptotagmin-5

2

0

High-throughput

0.288

High

445681

KCRM
Creatine kinase M-type

2

0

High-throughput

0.288

High

1052968

FOLC
Folylpolyglutamate synthase, mitochondrial

2

0

High-throughput

0.288

High

1308331

LACC1
Purine nucleoside phosphorylase LACC1

2

0

High-throughput

0.288

High

1340261

MSPD2
Motile sperm domain-containing protein 2

2

0

High-throughput

0.288

High

1454698

E2AK4
eIF-2-alpha kinase GCN2

2

0

High-throughput

0.288

High

1490683

AP3M1
AP-3 complex subunit mu-1

2

0

High-throughput

0.288

High

471327

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.279

Low

766031

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.279

Low

866876

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.279

Low

968493

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

0

High-throughput

0.279

Low

1459756

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.279

Low

680545

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

0

High-throughput

0.269

Low

210618

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

0

High-throughput

0.249

Low

243329

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.249

Low

373539

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

377786

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

483266

CLCA
Clathrin light chain A

1

0

High-throughput

0.249

Low

535693

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.249

Low

593248

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.249

Low

603391

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.249

Low

619139

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

0

High-throughput

0.249

Low

657719

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.249

Low

699902

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

High-throughput

0.249

Low

714530

PML
Protein PML

1

0

High-throughput

0.249

Low

731716

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.249

Low

1045931

TF65
Transcription factor p65

1

0

High-throughput

0.249

Low

1141065

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1156248

ZYX
Zyxin

1

0

High-throughput

0.249

Low

1289735

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.249

Low

1358146

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.249

Low

1364714

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.249

Low

1396868

SNX27
Sorting nexin-27

1

0

High-throughput

0.249

Low

1410408

MEP50
Methylosome protein WDR77

1

0

High-throughput

0.249

Low

1417107

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.249

Low

1430649

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.249

Low

1431350

ATG5
Autophagy protein 5

1

0

High-throughput

0.249

Low

1454118

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.249

Low

1458937

ZO2
Tight junction protein 2

1

0

High-throughput

0.249

Low

1459362

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1490638

FBW1A
F-box/WD repeat-containing protein 1A

1

0

High-throughput

0.249

Low

1490684

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.249

Low

332346

ATE1
Arginyl-tRNA--protein transferase 1

1

0

High-throughput

0.232

Low

516607

CALM3
Calmodulin-3

1

0

High-throughput

0.232

Low

1324692

GPD1L
Glycerol-3-phosphate dehydrogenase 1-like protein

1

0

High-throughput

0.232

Low

1370479

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025