HitPredict

Interactor 1: GRB14 (O88900)
Growth factor receptor-bound protein 14 (GRB14 adapter protein)
Gene: GRB14

Interactor 2: INSR (P15127)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	25687571
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005768 - endosome GO:0005886 - plasma membrane GO:0008286 - insulin receptor signaling pathway GO:0032869 - cellular response to insulin stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 538 Rn			1 1383
+	Rn
		292434 GRB14_RAT (1-538): 0: 651: 100.00		T2CB11_RAT (1-1383): 0: 1570: 99.42
+	Hs
		411383 GRB14_HUMAN (1-538): 0: 629: 85.00		INSR_HUMAN (27-1383): 0: 1527: 95.43
+	Hs
		411376 GRB10_HUMAN (5-538): 0: 537: 52.71		INSR_HUMAN (27-1383): 0: 1527: 95.43
+	Hs
		411384 GRB7_HUMAN (33-538): 3.72e-166: 483: 47.29		INSR_HUMAN (27-1383): 0: 1527: 95.43
+	Hs
		435642 GRB14_HUMAN (1-538): 0: 629: 85.00		IGF1R_HUMAN (13-1381): 0: 1302: 55.77
+	Hs
		435632 GRB10_HUMAN (5-538): 0: 537: 52.71		IGF1R_HUMAN (13-1381): 0: 1302: 55.77
+	Hs
		872640 GRB10_HUMAN (5-538): 0: 537: 52.71		EPHA4_HUMAN (662-1328): 0: 570: 24.19
+	Hs
		872612 GRB10_HUMAN (5-538): 0: 537: 52.71		EPHB1_HUMAN (661-1321): 1.37e-174: 547: 24.16
+	Hs
		872614 GRB7_HUMAN (33-538): 3.72e-166: 483: 47.29		EPHB1_HUMAN (661-1321): 1.37e-174: 547: 24.16
+	Hs
		1031671 GRB10_HUMAN (5-538): 0: 537: 52.71		NTRK2_HUMAN (997-1293): 1.8e-67: 246: 42.72
+	Hs
		338431 GRB14_HUMAN (1-538): 0: 629: 85.00		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		383805 GRB14_HUMAN (1-538): 0: 629: 85.00		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83
+	Hs
		338370 GRB10_HUMAN (5-538): 0: 537: 52.71		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		1031667 GRB10_HUMAN (5-538): 0: 537: 52.71		ERBB4_HUMAN (44-347): 2.97e-26: 119: 20.42
+	Hs
		383780 GRB10_HUMAN (5-538): 0: 537: 52.71		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83
+	Hs
		601921 GRB7_HUMAN (33-538): 3.72e-166: 483: 47.29		ERBB3_HUMAN (5-368): 5.74e-31: 135: 19.70
+	Hs
		338432 GRB7_HUMAN (33-538): 3.72e-166: 483: 47.29		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		1054054 GRB7_HUMAN (33-538): 3.72e-166: 483: 47.29		ERBB4_HUMAN (44-347): 2.97e-26: 119: 20.42
+	Hs
		383806 GRB7_HUMAN (33-538): 3.72e-166: 483: 47.29		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83
+	Mm
		654977 VAV_MOUSE (83-532): 1.38e-96: 313: 17.14		EGFR_MOUSE (32-300): 1.49e-27: 123: 24.12