HitPredict

Interactor 1: SMC1A (O93308)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1A) (xSMC1)
Gene: SMC1A

Interactor 2: STAG2 (Q9DGN0)
Cohesin subunit SA-2 (xSA-2) (SCC3 homolog 2) (Stromal antigen 2 homolog)
Gene: STAG2

Species: Xenopus laevis

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	10931856
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0007062 - sister chromatid cohesion GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1232 Xl			1 1194
+	Xl
		292732 SMC1A_XENLA (1-1232): 1.83e-119: 402: 100.00		Q5XGV2_XENLA (1-1194): 0: 1644: 97.82
+	Mm
		193223 SMC1A_MOUSE (1-1232): 8.04e-123: 411: 93.99		STAG2_MOUSE (1-1194): 0: 1574: 88.50
+	Hs
		1057313 SMC1A_HUMAN (1-1232): 1.59e-122: 411: 93.91		STAG2_HUMAN (1-1194): 0: 1572: 88.42
+	Hs
		1057335 SMC1A_HUMAN (1-1232): 1.59e-122: 411: 93.91		STAG1_HUMAN (2-1194): 0: 1553: 71.19
+	Mm
		193221 SMC1B_MOUSE (1-1226): 3.45e-102: 354: 52.53		STAG2_MOUSE (1-1194): 0: 1574: 88.50
+	Xl
		292735 SMC1A_XENLA (1-1232): 1.83e-119: 402: 100.00		STAG1_XENLA (2-1194): 0: 1526: 70.39
+	Xl
		1140122 Q8AW91_XENLA (3-1225): 7.38e-75: 273: 17.03		Q5XGV2_XENLA (1-1194): 0: 1644: 97.82
+	Xl
		1206293 Q8AW91_XENLA (3-1225): 7.38e-75: 273: 17.03		STAG2_XENLA (1-1194): 0: 1634: 100.00
+	Mm
		1265314 SMC1B_MOUSE (1-1226): 3.45e-102: 354: 52.53		STAG1_MOUSE (2-1194): 0: 1546: 71.19
+	Mm
		193224 SMC3_MOUSE (3-1212): 2.8e-75: 275: 17.70		STAG2_MOUSE (1-1194): 0: 1574: 88.50
+	Hs
		1232591 SMC3_HUMAN (3-1212): 3.33e-75: 275: 17.70		STAG2_HUMAN (1-1194): 0: 1572: 88.42
+	Hs
		1261592 SMC3_HUMAN (3-1212): 3.33e-75: 275: 17.70		STAG1_HUMAN (2-1194): 0: 1553: 71.19
+	Hs
		1057419 SMC1A_HUMAN (1-1232): 1.59e-122: 411: 93.91		STAG3_HUMAN (4-1094): 0: 1298: 51.41
+	Hs
		1355962 SMC3_HUMAN (3-1212): 3.33e-75: 275: 17.70		STAG3_HUMAN (4-1094): 0: 1298: 51.41
+	Mm
		251066 SMC1B_MOUSE (1-1226): 3.45e-102: 354: 52.53		STAG3_MOUSE (2-1094): 0: 1213: 50.32
+	Mm
		251067 SMC3_MOUSE (3-1212): 2.8e-75: 275: 17.70		STAG3_MOUSE (2-1094): 0: 1213: 50.32
+	Dm
		1362841 Q9VCD8_DROME (2-1226): 1.66e-87: 312: 47.68		Q9VM62_DROME (3-1000): 0: 1102: 46.27
+	Sp
		143296 SMC1_SCHPO (1-1225): 1.13e-74: 273: 32.45		SCC3_SCHPO (8-674): 0: 593: 21.56
+	Sp
		293287 SMC1_SCHPO (1-1225): 1.13e-74: 273: 32.45		REC11_SCHPO (12-639): 2.77e-150: 476: 15.58
+	Sc
		775340 SMC3_YEAST (3-1215): 9.56e-77: 279: 18.45		SCC3_YEAST (8-350): 7.1e-79: 284: 25.00