Protein: SAC1
Phosphatidylinositol-3-phosphatase SAC1 (EC 3.1.3.64) (Phosphatidylinositol-4-phosphate phosphatase) (Suppressor of actin mutations 1-like protein)

Gene: SAC1, SACM1L
Organism: Homo sapiens
Interactions: 210
UniProt ID: Q9NTJ5

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004438 - phosphatidylinositol-3-phosphate phosphatase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

149754

COPE
Coatomer subunit epsilon

4

0

Small-scale

0.670

High

1345756

COPG1
Coatomer subunit gamma-1

3

5

Small-scale

0.667

High

863576

COPA
Coatomer subunit alpha

2

2

Small-scale

0.649

High

307132

RTN3
Reticulon-3

3

2

High-throughput

0.647

High

1345751

DHRS7
Dehydrogenase/reductase SDR family member 7

3

2

High-throughput

0.647

High

863347

COPB
Coatomer subunit beta

2

3

Small-scale

0.634

High

1266807

TM9S4
Transmembrane 9 superfamily member 4

2

1

High-throughput

0.628

High

310834

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

3

Small-scale

0.611

High

603093

OSBP1
Oxysterol-binding protein 1

2

4

Small-scale

0.611

High

1345743

VAPA
Vesicle-associated membrane protein-associated protein A

2

3

Small-scale

0.611

High

885952

EVA1C
Protein eva-1 homolog C

3

1

High-throughput

0.609

High

1268666

LPAR1
Lysophosphatidic acid receptor 1

3

2

High-throughput

0.609

High

1329012

P2Y12
P2Y purinoceptor 12

3

3

High-throughput

0.609

High

1168536

RN19B
E3 ubiquitin-protein ligase RNF19B

2

4

High-throughput

0.606

High

1191214

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

2

High-throughput

0.606

High

1285279

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

1

High-throughput

0.606

High

228836

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

680503

FMO3
Flavin-containing monooxygenase 3

2

0

High-throughput

0.580

High

1068364

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.580

High

1133402

ZFY27
Protrudin

2

0

High-throughput

0.580

High

1234935

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.580

High

1310964

S35A5
UDP-sugar transporter protein SLC35A5

2

0

High-throughput

0.580

High

1343523

S35C2
Solute carrier family 35 member C2

2

0

High-throughput

0.580

High

1345225

KISHB
Protein kish-B

2

0

High-throughput

0.580

High

1345750

TMX2
Thioredoxin-related transmembrane protein 2

2

0

High-throughput

0.580

High

902374

COPZ1
Coatomer subunit zeta-1

2

0

High-throughput

0.576

High

199964

SPIT2
Kunitz-type protease inhibitor 2

2

1

High-throughput

0.558

High

134417

ACKR2
Atypical chemokine receptor 2

2

2

High-throughput

0.553

High

183304

FFAR2
Free fatty acid receptor 2

2

7

High-throughput

0.553

High

1060727

NTCP
Hepatic sodium/bile acid cotransporter

2

1

High-throughput

0.553

High

1108643

SOAT
Sodium-dependent organic anion transporter

2

1

High-throughput

0.553

High

1110102

AR13B
ADP-ribosylation factor-like protein 13B

2

3

High-throughput

0.553

High

1255431

GP152
Probable G-protein coupled receptor 152

2

4

High-throughput

0.553

High

335556

NB5R3
NADH-cytochrome b5 reductase 3

1

1

High-throughput

0.536

High

725578

COPB2
Coatomer subunit beta'

1

2

High-throughput

0.536

High

847680

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.536

High

1240324

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.536

High

1302538

OSBL9
Oxysterol-binding protein-related protein 9

1

4

High-throughput

0.536

High

819031

COPD
Coatomer subunit delta

2

0

Small-scale

0.528

High

566489

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.518

High

306955

CSPG5
Chondroitin sulfate proteoglycan 5

1

0

High-throughput

0.513

High

529785

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

848976

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.513

High

1019269

TM115
Transmembrane protein 115

1

0

High-throughput

0.513

High

1053826

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1234735

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.513

High

1261647

SCFD1
Sec1 family domain-containing protein 1

1

0

High-throughput

0.513

High

1283297

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1328608

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

1333639

MANS1
MANSC domain-containing protein 1

1

0

High-throughput

0.513

High

216847

CREB3
Cyclic AMP-responsive element-binding protein 3

1

1

High-throughput

0.508

High

1345735

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

Small-scale

0.493

High

156942

FFAR1
Free fatty acid receptor 1

1

6

High-throughput

0.489

High

172245

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.489

High

598785

S1PR1
Sphingosine 1-phosphate receptor 1

1

2

High-throughput

0.489

High

782480

P2RY2
P2Y purinoceptor 2

1

5

High-throughput

0.489

High

814596

P2RY1
P2Y purinoceptor 1

1

4

High-throughput

0.489

High

849714

CCR6
C-C chemokine receptor type 6

1

1

High-throughput

0.489

High

1067628

P2RY6
P2Y purinoceptor 6

1

5

High-throughput

0.489

High

1078232

CD226
CD226 antigen

1

1

High-throughput

0.489

High

1154030

K2C80
Keratin, type II cytoskeletal 80

1

1

High-throughput

0.489

High

1202745

P2RY8
P2Y purinoceptor 8

1

5

High-throughput

0.489

High

1284462

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

1

High-throughput

0.489

High

1306443

CML1
Chemerin-like receptor 1

1

2

High-throughput

0.489

High

1327659

BRD8
Bromodomain-containing protein 8

1

2

High-throughput

0.489

High

1335593

LPAR2
Lysophosphatidic acid receptor 2

1

2

High-throughput

0.489

High

1335880

GPR35
G-protein coupled receptor 35

1

4

High-throughput

0.489

High

1336695

TM9S3
Transmembrane 9 superfamily member 3

1

1

High-throughput

0.489

High

1345737

EVA1B
Protein eva-1 homolog B

1

1

High-throughput

0.489

High

206036

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

323197

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

726440

BASI
Basigin

1

1

High-throughput

0.479

High

738994

SRBP1
Sterol regulatory element-binding protein 1

1

2

Small-scale

0.479

High

764704

CUX1
Homeobox protein cut-like 1

1

2

High-throughput

0.479

High

1016034

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

1

Small-scale

0.479

High

1016108

SRBP2
Sterol regulatory element-binding protein 2

1

2

Small-scale

0.479

High

1042637

CUL3
Cullin-3

1

1

High-throughput

0.479

High

387597

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

1101324

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1165993

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1220996

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

1292359

RN185
E3 ubiquitin-protein ligase RNF185

1

0

High-throughput

0.458

High

1294047

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

48530

ESYT2
Extended synaptotagmin-2

1

2

High-throughput

0.445

High

99824

F5H6I7
Atlastin GTPase 3

1

2

High-throughput

0.445

High

258978

RTN2
Reticulon-2

1

3

High-throughput

0.445

High

502599

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.445

High

653743

CALR
Calreticulin

1

1

High-throughput

0.445

High

654827

CALX
Calnexin

1

1

High-throughput

0.445

High

833349

TMEDA
Transmembrane emp24 domain-containing protein 10

1

3

High-throughput

0.445

High

924184

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

2

High-throughput

0.445

High

950724

ARF5
ADP-ribosylation factor 5

1

1

High-throughput

0.445

High

961844

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.445

High

1047404

CASP
Protein CASP

1

3

High-throughput

0.445

High

1071848

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.445

High

1121020

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

4

High-throughput

0.445

High

1130640

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

1165432

LCLT1
Lysocardiolipin acyltransferase 1

1

1

High-throughput

0.445

High

1224291

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

1

High-throughput

0.445

High

1245551

ATLA2
Atlastin-2

1

2

High-throughput

0.445

High

1263631

ATLA1
Atlastin-1

1

2

High-throughput

0.445

High

1296178

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.445

High

1311419

ESYT1
Extended synaptotagmin-1

1

2

High-throughput

0.445

High

1330218

TMX1
Thioredoxin-related transmembrane protein 1

1

1

High-throughput

0.445

High

1343292

RTN4
Reticulon-4

1

2

High-throughput

0.445

High

1345745

COPG2
Coatomer subunit gamma-2

1

5

High-throughput

0.445

High

1345752

TMED5
Transmembrane emp24 domain-containing protein 5

1

2

High-throughput

0.445

High

360460

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.439

High

129841

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

High-throughput

0.437

High

385588

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

455917

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.437

High

553835

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

652372

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

721564

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

941477

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

999133

EP300
Histone acetyltransferase p300

1

4

High-throughput

0.437

High

1036126

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

1171911

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1201924

TAXB1
Tax1-binding protein 1

1

2

High-throughput

0.437

High

1204846

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.437

High

1222109

S15A3
Solute carrier family 15 member 3

1

2

High-throughput

0.437

High

1272636

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.437

High

1331405

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

1345747

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

50255

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.426

High

58156

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.426

High

199401

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.426

High

202982

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.426

High

266258

ERLN1
Erlin-1

1

0

High-throughput

0.426

High

532229

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.426

High

847372

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.426

High

945894

NUCB2
Nucleobindin-2

1

0

High-throughput

0.426

High

1026782

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.426

High

1058563

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.426

High

1062684

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.426

High

1065333

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.426

High

1065438

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

1070931

RCN1
Reticulocalbin-1

1

0

High-throughput

0.426

High

1072970

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.426

High

1077724

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.426

High

1237007

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.426

High

1241641

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.426

High

1243413

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.426

High

1246322

MCFD2
Multiple coagulation factor deficiency protein 2

1

0

High-throughput

0.426

High

1282657

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.426

High

1287039

ASTRA
Protein Aster-A

1

0

High-throughput

0.426

High

1310909

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.426

High

1319265

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.426

High

1329575

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

1345742

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

1345753

TRPV2
Transient receptor potential cation channel subfamily V member 2

1

1

Small-scale

0.417

High

99685

F5H1C8
Solute carrier family 15 member 3

1

2

High-throughput

0.407

High

277140

STAM2
Signal transducing adapter molecule 2

1

6

High-throughput

0.407

High

398106

ISG15
Ubiquitin-like protein ISG15

1

2

Small-scale

0.407

High

497660

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.407

High

1174543

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

2

High-throughput

0.407

High

1345741

PSD3
PH and SEC7 domain-containing protein 3

1

1

High-throughput

0.407

High

1217747

S22A9
Organic anion transporter 7

2

0

High-throughput

0.328

High

516150

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.316

High

676627

CTR1
High affinity cationic amino acid transporter 1

2

0

High-throughput

0.316

High

1037741

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

1101614

ODFP4
Outer dense fiber protein 4

2

0

High-throughput

0.316

High

1115709

MTEF2
Transcription termination factor 2, mitochondrial

2

0

High-throughput

0.316

High

1131216

MF14B
Hippocampus abundant transcript-like protein 1

2

0

High-throughput

0.316

High

1255486

GP151
G-protein coupled receptor 151

2

0

High-throughput

0.316

High

1326904

MFF
Mitochondrial fission factor

2

0

High-throughput

0.316

High

1345740

SCN3B
Sodium channel regulatory subunit beta-3

2

0

High-throughput

0.316

High

283665

JTB
Protein JTB

1

0

High-throughput

0.279

Low

353091

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.279

Low

530269

ICAM2
Intercellular adhesion molecule 2

1

0

High-throughput

0.279

Low

686396

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.279

Low

702303

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

1174898

SMIM5
Small integral membrane protein 5

1

0

High-throughput

0.279

Low

1219044

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1233050

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1246044

NEDD1
Protein NEDD1

1

0

High-throughput

0.279

Low

1261148

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

1272237

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

High-throughput

0.279

Low

1296201

COX42
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

1

0

High-throughput

0.279

Low

1306871

FOXB1
Forkhead box protein B1

1

0

High-throughput

0.279

Low

1333286

PACC1
Proton-activated chloride channel

1

0

High-throughput

0.279

Low

1333898

IPPK
Inositol-pentakisphosphate 2-kinase

1

0

High-throughput

0.279

Low

1345744

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

1345746

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

0

High-throughput

0.279

Low

1345749

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

0

High-throughput

0.279

Low

1345754

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

1128733

F209A
Protein FAM209A

1

0

High-throughput

0.251

Low

1335519

VEZA
Vezatin

1

0

High-throughput

0.251

Low

504827

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.249

Low

1029928

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

1087618

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

1148810

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1345736

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1345748

TES
Testin

1

0

High-throughput

0.249

Low

201066

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.232

Low

297792

MICA2
[F-actin]-monooxygenase MICAL2

1

0

High-throughput

0.232

Low

432956

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.232

Low

822173

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.232

Low

827851

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

High-throughput

0.232

Low

1243797

VP37A
Vacuolar protein sorting-associated protein 37A

1

0

High-throughput

0.232

Low

1301394

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low

1310771

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.232

Low

1312433

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.232

Low

1318105

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.232

Low

1327782

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.232

Low

1336765

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.232

Low

1345738

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.232

Low

1345739

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.232

Low

1345755

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024