HitPredict

Interactor 1: SMC3 (O93309)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3)
Gene: SMC3

Interactor 2: STAG2 (Q9DGN0)
Cohesin subunit SA-2 (xSA-2) (SCC3 homolog 2) (Stromal antigen 2 homolog)
Gene: STAG2

Species: Xenopus laevis

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	15855230, 10931856
Identification Methods	anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000775 - chromosome, centromeric region GO:0000785 - chromatin GO:0005634 - nucleus GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1209 Xl			1 1194
+	Xl
		1140122 Q8AW91_XENLA (1-1209): 1.41e-121: 407: 98.93		Q5XGV2_XENLA (1-1194): 0: 1644: 97.82
+	Xl
		1206293 Q8AW91_XENLA (1-1209): 1.41e-121: 407: 98.93		STAG2_XENLA (1-1194): 0: 1634: 100.00
+	Mm
		193224 SMC3_MOUSE (1-1209): 3.68e-119: 401: 95.81		STAG2_MOUSE (1-1194): 0: 1574: 88.50
+	Hs
		1232591 SMC3_HUMAN (1-1209): 6.66e-119: 400: 95.73		STAG2_HUMAN (1-1194): 0: 1572: 88.42
+	Hs
		1261592 SMC3_HUMAN (1-1209): 6.66e-119: 400: 95.73		STAG1_HUMAN (2-1194): 0: 1553: 71.19
+	Xl
		292742 SMC3_XENLA (1-1209): 6.91e-124: 413: 100.00		STAG1_XENLA (2-1194): 0: 1526: 70.39
+	Xl
		292732 SMC1A_XENLA (2-1203): 4.03e-68: 253: 15.33		Q5XGV2_XENLA (1-1194): 0: 1644: 97.82
+	Xl
		292734 SMC1A_XENLA (2-1203): 4.03e-68: 253: 15.33		STAG2_XENLA (1-1194): 0: 1634: 100.00
+	Mm
		193223 SMC1A_MOUSE (2-1203): 1.02e-72: 267: 16.27		STAG2_MOUSE (1-1194): 0: 1574: 88.50
+	Hs
		1057313 SMC1A_HUMAN (2-1203): 1.02e-72: 267: 16.27		STAG2_HUMAN (1-1194): 0: 1572: 88.42
+	Hs
		1057335 SMC1A_HUMAN (2-1203): 1.02e-72: 267: 16.27		STAG1_HUMAN (2-1194): 0: 1553: 71.19
+	Hs
		1355962 SMC3_HUMAN (1-1209): 6.66e-119: 400: 95.73		STAG3_HUMAN (4-1094): 0: 1298: 51.41
+	Mm
		251067 SMC3_MOUSE (1-1209): 3.68e-119: 401: 95.81		STAG3_MOUSE (2-1094): 0: 1213: 50.32
+	Hs
		1057419 SMC1A_HUMAN (2-1203): 1.02e-72: 267: 16.27		STAG3_HUMAN (4-1094): 0: 1298: 51.41
+	Sp
		143294 SMC3_SCHPO (1-1204): 4.03e-86: 307: 38.97		SCC3_SCHPO (8-674): 0: 593: 21.56
+	Sp
		143296 SMC1_SCHPO (2-1196): 3.88e-73: 268: 15.69		SCC3_SCHPO (8-674): 0: 593: 21.56
+	Sp
		193879 SMC3_SCHPO (1-1204): 4.03e-86: 307: 38.97		REC11_SCHPO (12-639): 2.77e-150: 476: 15.58
+	Sp
		293287 SMC1_SCHPO (2-1196): 3.88e-73: 268: 15.69		REC11_SCHPO (12-639): 2.77e-150: 476: 15.58
+	Sc
		775340 SMC3_YEAST (1-1209): 1.82e-81: 293: 29.50		SCC3_YEAST (8-350): 7.1e-79: 284: 25.00
+	Sc
		700774 SMC1_YEAST (2-1196): 5.51e-69: 255: 17.59		SCC3_YEAST (8-350): 7.1e-79: 284: 25.00