HitPredict

Interactor 1: SMC1 (O94383)
Structural maintenance of chromosomes protein 1 (Chromosome segregation protein smc1) (Cohesin complex subunit psm1)
Gene: psm1

Interactor 2: MIS4 (Q09725)
Sister chromatid cohesion protein mis4 (SCC2 homolog)
Gene: MIS4

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	26687354, 31895039
Identification Methods	biochemical, pull down, affinity chromatography technology
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	Nipped-B_C~SMC_N
Common GO terms	GO:0005634 - nucleus GO:0007064 - mitotic sister chromatid cohesion GO:0016887 - ATP hydrolysis activity GO:0140588 - chromatin looping
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1228 Sp			1 1587
+	Mm
		1154101 SMC1A_MOUSE (1-1226): 1.97e-93: 328: 32.50		NIPBL_MOUSE (193-1496): 0: 1348: 18.98
+	Hs
		1057289 SMC1A_HUMAN (1-1226): 2.19e-93: 328: 32.50		NIPBL_HUMAN (193-1496): 0: 1347: 19.09
+	Mm
		1154102 SMC3_MOUSE (3-1225): 2.53e-72: 266: 14.47		NIPBL_MOUSE (193-1496): 0: 1348: 18.98
+	Hs
		1154087 SMC3_HUMAN (3-1225): 3.12e-72: 265: 14.47		NIPBL_HUMAN (193-1496): 0: 1347: 19.09
+	Sc
		700798 SMC1_YEAST (1-1228): 2.12e-79: 287: 33.01		SCC2_YEAST (323-1482): 0: 965: 22.18
+	Sc
		758755 SMC2_YEAST (3-1219): 7.07e-72: 264: 15.87		SCC2_YEAST (323-1482): 0: 965: 22.18
+	Sc
		810771 SMC3_YEAST (3-1219): 9.65e-66: 246: 16.04		SCC2_YEAST (323-1482): 0: 965: 22.18