Protein: HS74L
Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94)

Gene: HS74L, HSPA4L
Organism: Homo sapiens
Interactions: 207
UniProt ID: O95757

Gene Ontology (top 5):
GO:0000774 - adenyl-nucleotide exchange factor activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

343885

HSP7C
Heat shock cognate 71 kDa protein

7

19

Small-scale

0.956

High

343994

HS105
Heat shock protein 105 kDa

6

17

High-throughput

0.931

High

343884

BIP
Endoplasmic reticulum chaperone BiP

4

20

High-throughput

0.895

High

226647

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

2

20

Small-scale

0.789

High

343905

HSP74
Heat shock 70 kDa protein 4

2

17

High-throughput

0.754

High

343899

DNJB1
DnaJ homolog subfamily B member 1

1

20

High-throughput

0.691

High

344007

TTC1
Tetratricopeptide repeat protein 1

1

20

High-throughput

0.691

High

344008

DNJC7
DnaJ homolog subfamily C member 7

1

20

High-throughput

0.691

High

344042

CHIP
E3 ubiquitin-protein ligase CHIP

1

20

High-throughput

0.691

High

240392

PRKN
E3 ubiquitin-protein ligase parkin

3

13

High-throughput

0.640

High

343908

SYUA
Alpha-synuclein

3

7

High-throughput

0.633

High

343900

DNJB2
DnaJ homolog subfamily B member 2

1

20

High-throughput

0.618

High

343904

STIP1
Stress-induced-phosphoprotein 1

1

20

High-throughput

0.618

High

343922

HSP72
Heat shock-related 70 kDa protein 2

1

19

High-throughput

0.618

High

343913

YAP1
Transcriptional coactivator YAP1

2

20

High-throughput

0.611

High

343935

HSF1
Heat shock factor protein 1

2

14

High-throughput

0.611

High

343989

MT21A
Protein N-lysine methyltransferase METTL21A

2

20

High-throughput

0.611

High

343874

P53
Cellular tumor antigen p53

2

11

High-throughput

0.594

High

343873

NTRK1
High affinity nerve growth factor receptor

2

20

High-throughput

0.584

High

343921

ATX3
Ataxin-3

2

8

Small-scale

0.584

High

343950

PTPRR
Receptor-type tyrosine-protein phosphatase R

2

6

High-throughput

0.584

High

344021

WDR76
WD repeat-containing protein 76

2

18

High-throughput

0.584

High

343996

Q96BE0
Heat shock cognate 71 kDa protein

1

19

High-throughput

0.575

High

343911

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

20

High-throughput

0.571

High

343941

GRB10
Growth factor receptor-bound protein 10

2

20

High-throughput

0.571

High

343954

ITSN1
Intersectin-1

2

11

High-throughput

0.571

High

344002

SCLT1
Sodium channel and clathrin linker 1

2

10

High-throughput

0.571

High

296684

TUSC2
Tumor suppressor candidate 2

2

3

High-throughput

0.567

High

332375

GRP1
RAS guanyl-releasing protein 1

1

2

High-throughput

0.536

High

343878

INSR
Insulin receptor

1

20

High-throughput

0.536

High

343887

SRF
Serum response factor

1

5

High-throughput

0.536

High

343888

CFTR
Cystic fibrosis transmembrane conductance regulator

1

9

High-throughput

0.536

High

343893

HNF1A
Hepatocyte nuclear factor 1-alpha

1

2

High-throughput

0.536

High

343918

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

High-throughput

0.536

High

343957

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.536

High

343958

MK06
Mitogen-activated protein kinase 6

1

20

High-throughput

0.536

High

343959

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.536

High

343970

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.536

High

343976

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

5

High-throughput

0.536

High

343979

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

7

High-throughput

0.536

High

343985

CGAS
Cyclic GMP-AMP synthase

1

2

High-throughput

0.536

High

344011

KLF16
Krueppel-like factor 16

1

16

High-throughput

0.536

High

344026

TF7L2
Transcription factor 7-like 2

1

10

High-throughput

0.536

High

344028

SMYD2
N-lysine methyltransferase SMYD2

1

2

High-throughput

0.536

High

344029

LATS2
Serine/threonine-protein kinase LATS2

1

18

High-throughput

0.536

High

105031

APRIO
Alternative prion protein

2

3

High-throughput

0.533

High

344036

S12A6
Solute carrier family 12 member 6

2

20

Small-scale

0.521

High

249703

DOK2
Docking protein 2

1

5

High-throughput

0.515

High

343877

K2C8
Keratin, type II cytoskeletal 8

1

2

High-throughput

0.515

High

343910

CCNF
Cyclin-F

1

4

High-throughput

0.515

High

343956

USF2
Upstream stimulatory factor 2

1

13

High-throughput

0.515

High

343927

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

6

High-throughput

0.501

High

343955

NEDD8
Ubiquitin-like protein NEDD8

1

7

Small-scale

0.501

High

339626

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.500

High

343879

SP1
Transcription factor Sp1

1

11

High-throughput

0.500

High

343881

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

20

High-throughput

0.500

High

343882

GLI2
Zinc finger protein GLI2

1

8

High-throughput

0.500

High

343892

CREB1
Cyclic AMP-responsive element-binding protein 1

1

4

High-throughput

0.500

High

344012

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

8

High-throughput

0.500

High

343945

PEBB
Core-binding factor subunit beta

1

2

High-throughput

0.489

High

343974

PAXI1
PAX-interacting protein 1

1

6

High-throughput

0.481

High

137900

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

11

Small-scale

0.479

High

174293

ZN609
Zinc finger protein 609

1

6

High-throughput

0.479

High

222614

PRC1
Protein regulator of cytokinesis 1

1

7

High-throughput

0.479

High

259266

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

292987

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

314984

RECQ4
ATP-dependent DNA helicase Q4

1

17

High-throughput

0.479

High

324376

HEXI1
Protein HEXIM1

1

5

High-throughput

0.479

High

330539

KI20A
Kinesin-like protein KIF20A

1

9

High-throughput

0.479

High

332732

EPM2A
Laforin

1

2

High-throughput

0.479

High

343866

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

343867

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.479

High

343869

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

343871

MYCN
N-myc proto-oncogene protein

1

11

High-throughput

0.479

High

343872

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.479

High

343875

H2A1B
Histone H2A type 1-B/E

1

6

High-throughput

0.479

High

343880

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.479

High

343886

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

343889

BRAF
Serine/threonine-protein kinase B-raf

1

16

High-throughput

0.479

High

343890

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

343895

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.479

High

343897

CRCM
Colorectal mutant cancer protein

1

2

High-throughput

0.479

High

343901

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

343902

EPHA8
Ephrin type-A receptor 8

1

12

High-throughput

0.479

High

343903

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

343907

VGFR3
Vascular endothelial growth factor receptor 3

1

9

High-throughput

0.479

High

343909

BRCA1
Breast cancer type 1 susceptibility protein

1

16

High-throughput

0.479

High

343912

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

13

Small-scale

0.479

High

343917

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

7

High-throughput

0.479

High

343919

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

9

High-throughput

0.479

High

343920

PLK1
Serine/threonine-protein kinase PLK1

1

15

High-throughput

0.479

High

343925

IF6
Eukaryotic translation initiation factor 6

1

1

High-throughput

0.479

High

343929

UBC12
NEDD8-conjugating enzyme Ubc12

1

6

High-throughput

0.479

High

343931

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

343932

ARF6
ADP-ribosylation factor 6

1

5

High-throughput

0.479

High

343933

H4
Histone H4

1

4

High-throughput

0.479

High

343934

RBX1
E3 ubiquitin-protein ligase RBX1

1

5

High-throughput

0.479

High

343937

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.479

High

343938

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

9

High-throughput

0.479

High

343940

RFA4
Replication protein A 30 kDa subunit

1

4

High-throughput

0.479

High

343942

BIRC3
Baculoviral IAP repeat-containing protein 3

1

9

High-throughput

0.479

High

343943

CUL3
Cullin-3

1

17

High-throughput

0.479

High

343946

NUMA1
Nuclear mitotic apparatus protein 1

1

6

High-throughput

0.479

High

343947

HAPR1
HUWE1-associated protein modifying stress responses 1

1

3

High-throughput

0.479

High

343948

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

343949

TCAL1
Transcription elongation factor A protein-like 1

1

1

High-throughput

0.479

High

343951

TERF2
Telomeric repeat-binding factor 2

1

5

High-throughput

0.479

High

343953

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

5

High-throughput

0.479

High

343961

LARP7
La-related protein 7

1

10

High-throughput

0.479

High

343962

PKHG4
Puratrophin-1

1

6

High-throughput

0.479

High

343963

EPHAA
Ephrin type-A receptor 10

1

9

High-throughput

0.479

High

343966

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.479

High

343971

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

10

High-throughput

0.479

High

343973

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.479

High

343975

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

13

High-throughput

0.479

High

343980

STK40
Serine/threonine-protein kinase 40

1

16

Small-scale

0.479

High

343983

SIR6
NAD-dependent protein deacylase sirtuin-6

1

13

High-throughput

0.479

High

343986

RN149
E3 ubiquitin-protein ligase RNF149

1

11

High-throughput

0.479

High

343987

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

343988

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

343990

ASB11
Ankyrin repeat and SOCS box protein 11

1

14

High-throughput

0.479

High

343991

SSH1
Protein phosphatase Slingshot homolog 1

1

9

High-throughput

0.479

High

343992

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

9

High-throughput

0.479

High

343995

CSN5
COP9 signalosome complex subunit 5

1

12

High-throughput

0.479

High

343997

ARMC5
Armadillo repeat-containing protein 5

1

10

High-throughput

0.479

High

343998

CHM4C
Charged multivesicular body protein 4c

1

6

High-throughput

0.479

High

344000

AURKB
Aurora kinase B

1

8

High-throughput

0.479

High

344001

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

344004

CIC
Protein capicua homolog

1

13

High-throughput

0.479

High

344005

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

6

High-throughput

0.479

High

344006

RUFY1
RUN and FYVE domain-containing protein 1

1

9

High-throughput

0.479

High

344009

ANM1
Protein arginine N-methyltransferase 1

1

5

High-throughput

0.479

High

344010

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

12

High-throughput

0.479

High

344016

TXNIP
Thioredoxin-interacting protein

1

8

Small-scale

0.479

High

344018

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

16

High-throughput

0.479

High

344019

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

5

High-throughput

0.479

High

344020

ECT2
Protein ECT2

1

12

High-throughput

0.479

High

344024

ARGAL
Rho guanine nucleotide exchange factor 10-like protein

1

9

High-throughput

0.479

High

344027

ANLN
Anillin

1

3

High-throughput

0.479

High

344030

PIHD1
PIH1 domain-containing protein 1

1

5

High-throughput

0.479

High

344031

FMN2
Formin-2

1

2

High-throughput

0.479

High

344032

KS6B2
Ribosomal protein S6 kinase beta-2

1

18

High-throughput

0.479

High

344034

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

344039

MYO5B
Unconventional myosin-Vb

1

5

High-throughput

0.479

High

344040

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.479

High

344041

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.479

High

344043

FAF1
FAS-associated factor 1

1

9

High-throughput

0.479

High

344047

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.479

High

344048

TRAF6
TNF receptor-associated factor 6

1

20

High-throughput

0.479

High

344049

MTCH2
Mitochondrial carrier homolog 2

1

10

High-throughput

0.479

High

344050

DUS10
Dual specificity protein phosphatase 10

1

9

High-throughput

0.479

High

344037

MSRA
Mitochondrial peptide methionine sulfoxide reductase

1

0

Small-scale

0.460

High

343960

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

139

A0A024R6X4
PLEKHG4

1

6

High-throughput

0.445

High

126946

APBB1
Amyloid beta precursor protein binding family B member 1

1

3

High-throughput

0.445

High

343876

JUN
Transcription factor Jun

1

15

High-throughput

0.445

High

343883

TAU
Microtubule-associated protein tau

1

19

High-throughput

0.445

High

343923

S12A3
Solute carrier family 12 member 3

1

20

High-throughput

0.445

High

343924

TERA
Transitional endoplasmic reticulum ATPase

1

11

High-throughput

0.445

High

343926

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

18

High-throughput

0.445

High

343928

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

343930

RHOA
Transforming protein RhoA

1

5

High-throughput

0.445

High

343952

SF01
Splicing factor 1

1

4

High-throughput

0.445

High

343964

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

14

High-throughput

0.445

High

343977

ZN546
Zinc finger protein 546

1

3

High-throughput

0.445

High

343984

ZN283
Zinc finger protein 283

1

5

High-throughput

0.445

High

343999

OTUB1
Ubiquitin thioesterase OTUB1

1

4

High-throughput

0.445

High

344015

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

20

High-throughput

0.445

High

344017

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

20

High-throughput

0.445

High

344025

ZN304
Zinc finger protein 304

1

5

High-throughput

0.445

High

344044

S12A4
Solute carrier family 12 member 4

1

20

High-throughput

0.445

High

344045

S27A5
Long-chain fatty acid transport protein 5

1

7

High-throughput

0.445

High

217672

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.437

High

343868

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.437

High

343894

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

10

High-throughput

0.437

High

343896

GCSP
Glycine dehydrogenase

1

3

High-throughput

0.437

High

343906

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

343916

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

High-throughput

0.437

High

343936

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

343965

RC3H1
Roquin-1

1

9

High-throughput

0.437

High

343967

RNF43
E3 ubiquitin-protein ligase RNF43

1

13

High-throughput

0.437

High

343969

LMBRL
Protein LMBR1L

1

3

High-throughput

0.437

High

343981

ABD12
Lysophosphatidylserine lipase ABHD12

1

4

High-throughput

0.437

High

343982

FBXL6
F-box/LRR-repeat protein 6

1

11

High-throughput

0.437

High

344013

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

5

Small-scale

0.437

High

344022

RC3H2
Roquin-2

1

13

High-throughput

0.437

High

344038

HECD1
E3 ubiquitin-protein ligase HECTD1

1

14

Small-scale

0.437

High

344046

AAR2
Protein AAR2 homolog

1

5

High-throughput

0.437

High

244911

KATIP
Katanin-interacting protein

1

0

High-throughput

0.426

High

343870

PRIO
Major prion protein

1

0

High-throughput

0.426

High

97213

E9PS44
Interferon induced transmembrane protein 3

1

1

High-throughput

0.407

High

261031

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.407

High

343898

SC6A2
Sodium-dependent noradrenaline transporter

1

9

High-throughput

0.407

High

343914

SC6A9
Sodium- and chloride-dependent glycine transporter 1

1

9

High-throughput

0.407

High

343915

EAA4
Excitatory amino acid transporter 4

1

1

High-throughput

0.407

High

343939

SLC31
Amino acid transporter heavy chain SLC3A1

1

4

High-throughput

0.407

High

343944

S12A1
Solute carrier family 12 member 1

1

20

High-throughput

0.407

High

343968

SL9A4
Sodium/hydrogen exchanger 4

1

11

High-throughput

0.407

High

343993

SL9A6
Sodium/hydrogen exchanger 6

1

11

High-throughput

0.407

High

344003

B3A4
Anion exchange protein 4

1

4

High-throughput

0.407

High

344014

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

9

High-throughput

0.407

High

344023

S38AA
Solute carrier family 38 member 10

1

2

High-throughput

0.407

High

344033

SL9A2
Sodium/hydrogen exchanger 2

1

11

High-throughput

0.407

High

344035

NPCL1
NPC1-like intracellular cholesterol transporter 1

1

3

High-throughput

0.407

High

343891

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

343978

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.249

Low

343972

MFSD6
Major facilitator superfamily domain-containing protein 6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025