Protein: HS74L
Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94)

Gene: HS74L, HSPA4L
Organism: Homo sapiens
Interactions: 173
UniProt ID: O95757

Gene Ontology (top 5):
GO:0000774 - adenyl-nucleotide exchange factor activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

320802

HSP7C
Heat shock cognate 71 kDa protein

6

17

Small-scale

0.938

High

320801

BIP
Endoplasmic reticulum chaperone BiP

4

19

High-throughput

0.895

High

320890

HS105
Heat shock protein 105 kDa

3

14

High-throughput

0.827

High

320814

DNJB1
DnaJ homolog subfamily B member 1

1

20

High-throughput

0.691

High

320902

DNJC7
DnaJ homolog subfamily C member 7

1

20

High-throughput

0.691

High

320929

CHIP
E3 ubiquitin-protein ligase CHIP

1

20

High-throughput

0.691

High

226163

PRKN
E3 ubiquitin-protein ligase parkin

3

13

High-throughput

0.640

High

320823

SYUA
Alpha-synuclein

3

6

High-throughput

0.633

High

320815

DNJB2
DnaJ homolog subfamily B member 2

1

20

High-throughput

0.618

High

320820

HSP74
Heat shock 70 kDa protein 4

1

14

High-throughput

0.618

High

320833

HSP72
Heat shock-related 70 kDa protein 2

1

18

High-throughput

0.618

High

213427

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

2

20

Small-scale

0.611

High

320827

YAP1
Transcriptional coactivator YAP1

2

15

High-throughput

0.611

High

320844

HSF1
Heat shock factor protein 1

2

14

High-throughput

0.611

High

320887

MT21A
Protein N-lysine methyltransferase METTL21A

2

20

High-throughput

0.611

High

320791

P53
Cellular tumor antigen p53

2

11

High-throughput

0.594

High

320790

NTRK1
High affinity nerve growth factor receptor

2

20

High-throughput

0.584

High

320832

ATX3
Ataxin-3

2

8

Small-scale

0.584

High

320855

PTPRR
Receptor-type tyrosine-protein phosphatase R

2

6

High-throughput

0.584

High

320914

WDR76
WD repeat-containing protein 76

2

16

High-throughput

0.584

High

320892

Q96BE0
Heat shock cognate 71 kDa protein

1

19

High-throughput

0.575

High

320826

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

20

High-throughput

0.571

High

320849

GRB10
Growth factor receptor-bound protein 10

2

20

High-throughput

0.571

High

320859

ITSN1
Intersectin-1

2

10

High-throughput

0.571

High

320897

SCLT1
Sodium channel and clathrin linker 1

2

9

High-throughput

0.571

High

277224

TUSC2
Tumor suppressor candidate 2

2

3

High-throughput

0.567

High

310025

GRP1
RAS guanyl-releasing protein 1

1

2

High-throughput

0.536

High

320795

INSR
Insulin receptor

1

20

High-throughput

0.536

High

320804

SRF
Serum response factor

1

5

High-throughput

0.536

High

320805

CFTR
Cystic fibrosis transmembrane conductance regulator

1

8

High-throughput

0.536

High

320810

HNF1A
Hepatocyte nuclear factor 1-alpha

1

3

High-throughput

0.536

High

320830

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

High-throughput

0.536

High

320862

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.536

High

320863

MK06
Mitogen-activated protein kinase 6

1

20

High-throughput

0.536

High

320864

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.536

High

320873

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.536

High

320877

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

5

High-throughput

0.536

High

320880

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

6

High-throughput

0.536

High

320884

CGAS
Cyclic GMP-AMP synthase

1

2

High-throughput

0.536

High

320901

TTC1
Tetratricopeptide repeat protein 1

1

20

High-throughput

0.536

High

320905

KLF16
Krueppel-like factor 16

1

15

High-throughput

0.536

High

320918

TF7L2
Transcription factor 7-like 2

1

8

High-throughput

0.536

High

320920

SMYD2
N-lysine methyltransferase SMYD2

1

2

High-throughput

0.536

High

320921

LATS2
Serine/threonine-protein kinase LATS2

1

18

High-throughput

0.536

High

235030

DOK2
Docking protein 2

1

5

High-throughput

0.515

High

320794

K2C8
Keratin, type II cytoskeletal 8

1

2

High-throughput

0.515

High

320825

CCNF
Cyclin-F

1

4

High-throughput

0.515

High

320861

USF2
Upstream stimulatory factor 2

1

13

High-throughput

0.515

High

320836

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

6

High-throughput

0.501

High

320860

NEDD8
NEDD8

1

7

Small-scale

0.501

High

316763

KLF8
Krueppel-like factor 8

1

18

High-throughput

0.500

High

320796

SP1
Transcription factor Sp1

1

13

High-throughput

0.500

High

320798

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

20

High-throughput

0.500

High

320799

GLI2
Zinc finger protein GLI2

1

7

High-throughput

0.500

High

320809

CREB1
Cyclic AMP-responsive element-binding protein 1

1

4

High-throughput

0.500

High

320906

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

8

High-throughput

0.500

High

320852

PEBB
Core-binding factor subunit beta

1

2

High-throughput

0.489

High

320876

PAXI1
PAX-interacting protein 1

1

4

High-throughput

0.481

High

130680

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

11

Small-scale

0.479

High

164171

ZN609
Zinc finger protein 609

1

6

High-throughput

0.479

High

209565

PRC1
Protein regulator of cytokinesis 1

1

7

High-throughput

0.479

High

243757

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

294233

RECQ4
ATP-dependent DNA helicase Q4

1

14

High-throughput

0.479

High

302750

HEXI1
Protein HEXIM1

1

5

High-throughput

0.479

High

308286

KI20A
Kinesin-like protein KIF20A

1

9

High-throughput

0.479

High

310375

EPM2A
Laforin

1

2

High-throughput

0.479

High

320783

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

320784

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.479

High

320786

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

320788

MYCN
N-myc proto-oncogene protein

1

11

High-throughput

0.479

High

320789

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.479

High

320792

H2A1B
Histone H2A type 1-B/E

1

6

High-throughput

0.479

High

320797

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.479

High

320803

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

320806

BRAF
Serine/threonine-protein kinase B-raf

1

16

High-throughput

0.479

High

320807

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

320811

FGFR3
Fibroblast growth factor receptor 3

1

19

High-throughput

0.479

High

320812

GCSP
Glycine dehydrogenase

1

3

High-throughput

0.479

High

320813

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

320816

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

320817

EPHA8
Ephrin type-A receptor 8

1

11

High-throughput

0.479

High

320818

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

320819

STIP1
Stress-induced-phosphoprotein 1

1

20

High-throughput

0.479

High

320822

VGFR3
Vascular endothelial growth factor receptor 3

1

9

High-throughput

0.479

High

320824

BRCA1
Breast cancer type 1 susceptibility protein

1

13

High-throughput

0.479

High

320829

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

6

High-throughput

0.479

High

320831

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

10

High-throughput

0.479

High

320834

IF6
Eukaryotic translation initiation factor 6

1

1

High-throughput

0.479

High

320838

UBC12
NEDD8-conjugating enzyme Ubc12

1

6

High-throughput

0.479

High

320840

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

320841

ARF6
ADP-ribosylation factor 6

1

5

High-throughput

0.479

High

320842

H4
Histone H4

1

4

High-throughput

0.479

High

320843

RBX1
E3 ubiquitin-protein ligase RBX1

1

5

High-throughput

0.479

High

320846

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.479

High

320847

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

9

High-throughput

0.479

High

320848

RFA4
Replication protein A 30 kDa subunit

1

4

High-throughput

0.479

High

320850

BIRC3
Baculoviral IAP repeat-containing protein 3

1

9

High-throughput

0.479

High

320851

CUL3
Cullin-3

1

17

High-throughput

0.479

High

320853

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

320856

TERF2
Telomeric repeat-binding factor 2

1

5

High-throughput

0.479

High

320858

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

5

High-throughput

0.479

High

320866

LARP7
La-related protein 7

1

10

High-throughput

0.479

High

320867

PKHG4
Puratrophin-1

1

4

High-throughput

0.479

High

320868

EPHAA
Ephrin type-A receptor 10

1

9

High-throughput

0.479

High

320874

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

8

High-throughput

0.479

High

320875

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

320881

STK40
Serine/threonine-protein kinase 40

1

16

Small-scale

0.479

High

320882

SIR6
NAD-dependent protein deacylase sirtuin-6

1

13

High-throughput

0.479

High

320885

RN149
E3 ubiquitin-protein ligase RNF149

1

11

High-throughput

0.479

High

320886

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

320888

SSH1
Protein phosphatase Slingshot homolog 1

1

9

High-throughput

0.479

High

320889

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

7

High-throughput

0.479

High

320891

CSN5
COP9 signalosome complex subunit 5

1

12

High-throughput

0.479

High

320893

ARMC5
Armadillo repeat-containing protein 5

1

10

High-throughput

0.479

High

320894

CHM4C
Charged multivesicular body protein 4c

1

5

High-throughput

0.479

High

320896

AURKB
Aurora kinase B

1

8

High-throughput

0.479

High

320898

CIC
Protein capicua homolog

1

11

High-throughput

0.479

High

320899

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

6

High-throughput

0.479

High

320900

RUFY1
RUN and FYVE domain-containing protein 1

1

8

High-throughput

0.479

High

320903

ANM1
Protein arginine N-methyltransferase 1

1

5

High-throughput

0.479

High

320904

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

13

High-throughput

0.479

High

320907

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

5

Small-scale

0.479

High

320909

TXNIP
Thioredoxin-interacting protein

1

8

Small-scale

0.479

High

320911

Q9H4D1
Protein kinase

1

16

High-throughput

0.479

High

320912

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

5

High-throughput

0.479

High

320913

ECT2
Protein ECT2

1

9

High-throughput

0.479

High

320916

ARGAL
Rho guanine nucleotide exchange factor 10-like protein

1

9

High-throughput

0.479

High

320919

ANLN
Anillin

1

3

High-throughput

0.479

High

320922

PIHD1
PIH1 domain-containing protein 1

1

5

High-throughput

0.479

High

320923

KS6B2
Ribosomal protein S6 kinase beta-2

1

18

High-throughput

0.479

High

320924

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

320927

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.479

High

320928

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.479

High

320930

FAF1
FAS-associated factor 1

1

9

High-throughput

0.479

High

320932

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.479

High

320933

TRAF6
TNF receptor-associated factor 6

1

20

High-throughput

0.479

High

320934

MTCH2
Mitochondrial carrier homolog 2

1

10

High-throughput

0.479

High

320935

DUS10
Dual specificity protein phosphatase 10

1

9

High-throughput

0.479

High

320925

MSRA
Mitochondrial peptide methionine sulfoxide reductase

1

0

Small-scale

0.460

High

320854

TCAL1
Transcription elongation factor A protein-like 1

1

0

High-throughput

0.458

High

320865

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

120785

APBB1
Amyloid beta precursor protein binding family B member 1

1

3

High-throughput

0.445

High

320793

JUN
Transcription factor Jun

1

15

High-throughput

0.445

High

320800

TAU
Microtubule-associated protein tau

1

18

High-throughput

0.445

High

320835

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

18

High-throughput

0.445

High

320837

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

320839

RHOA
Transforming protein RhoA

1

5

High-throughput

0.445

High

320857

SF01
Splicing factor 1

1

4

High-throughput

0.445

High

320869

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

14

High-throughput

0.445

High

320878

ZN546
Zinc finger protein 546

1

3

High-throughput

0.445

High

320883

ZN283
Zinc finger protein 283

1

5

High-throughput

0.445

High

320895

OTUB1
Ubiquitin thioesterase OTUB1

1

4

High-throughput

0.445

High

320908

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

20

High-throughput

0.445

High

320910

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

20

High-throughput

0.445

High

320917

ZN304
Zinc finger protein 304

1

5

High-throughput

0.445

High

100349

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

204886

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.437

High

320785

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.437

High

320821

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

320828

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

High-throughput

0.437

High

320845

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

320870

RC3H1
Roquin-1

1

9

High-throughput

0.437

High

320871

RNF43
E3 ubiquitin-protein ligase RNF43

1

15

High-throughput

0.437

High

320872

LMBRL
Protein LMBR1L

1

3

High-throughput

0.437

High

320915

RC3H2
Roquin-2

1

13

High-throughput

0.437

High

320926

HECD1
E3 ubiquitin-protein ligase HECTD1

1

12

Small-scale

0.437

High

320931

AAR2
Protein AAR2 homolog

1

5

High-throughput

0.437

High

230563

KATIP
Katanin-interacting protein

1

0

High-throughput

0.426

High

320787

PRIO
Major prion protein

1

0

High-throughput

0.426

High

139

A0A024R6X4
PLEKHG4

1

4

High-throughput

0.407

High

92754

E9PS44
Interferon induced transmembrane protein 3

1

1

High-throughput

0.407

High

320808

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

320879

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024