HitPredict

Interactor 1: CSN5 (O94454)
COP9 signalosome complex subunit 5 (EC 3.4.-.-)
Gene: CSN5

Interactor 2: CUL3 (Q09760)
Cullin-3 (Cul-3)
Gene: CUL3

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11504566
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cullin_Nedd8~JAB
Common GO terms	GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 299 Sp			1 785
+	Hs
		1042204 CSN5_HUMAN (4-299): 1.22e-95: 287: 38.85		CUL3_HUMAN (2-785): 0: 803: 35.97
+	At
		1227343 CSN5A_ARATH (2-298): 3.05e-95: 287: 38.05		CUL3A_ARATH (2-785): 0: 798: 34.73
+	Hs
		1043142 CSN5_HUMAN (4-299): 1.22e-95: 287: 38.85		CUL4A_HUMAN (1-785): 0: 792: 31.89
+	Hs
		1043493 CSN5_HUMAN (4-299): 1.22e-95: 287: 38.85		CUL4B_HUMAN (1-785): 0: 781: 31.26
+	Hs
		849195 PSMD7_HUMAN (32-298): 2.77e-70: 222: 14.03		CUL3_HUMAN (2-785): 0: 803: 35.97
+	At
		1228142 CSN5B_ARATH (2-298): 5.26e-94: 284: 37.74		CUL4_ARATH (1-785): 0: 729: 33.76
+	Hs
		1041128 CSN5_HUMAN (4-299): 1.22e-95: 287: 38.85		CUL1_HUMAN (10-785): 0: 721: 26.12
+	Ce
		954204 CSN5_CAEEL (5-292): 3.58e-90: 274: 39.24		CUL3_CAEEL (6-785): 0: 708: 31.99
+	Hs
		177020 EIF3H_HUMAN (29-299): 6.19e-55: 183: 15.02		CUL4A_HUMAN (1-785): 0: 792: 31.89
+	Hs
		805526 BRCC3_HUMAN (36-299): 4.11e-50: 170: 16.56		CUL3_HUMAN (2-785): 0: 803: 35.97
+	Hs
		124855 EIF3F_HUMAN (22-298): 3.49e-48: 166: 12.97		CUL3_HUMAN (2-785): 0: 803: 35.97
+	Hs
		1041423 CSN5_HUMAN (4-299): 1.22e-95: 287: 38.85		CUL2_HUMAN (13-785): 0: 671: 23.51
+	Sp
		142913 CSN5_SCHPO (1-299): 2.28e-91: 275: 100.00		CUL1_SCHPO (17-785): 0: 653: 24.81
+	Hs
		1272513 CSN5_HUMAN (4-299): 1.22e-95: 287: 38.85		CUL5_HUMAN (19-785): 0: 592: 21.19
+	Sc
		1014851 CSN5_YEAST (26-205): 3.13e-46: 163: 34.74		CDC53_YEAST (17-785): 0: 584: 20.60