HitPredict

Interactor 1: TOM70 (O94826)
Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70)
Gene: TOMM70

Interactor 2: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.76 1.00 0.873

The method score is based on:

Property Details
Experiments 35643212, 33990585, 20628368
Identification Methods pull down, unspecified method, affinity chromatography technology, anti tag coimmunoprecipitation, isothermal titration calorimetry
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains HSP90~TPR_8
Common GO terms GO:0002218 - activation of innate immune response
GO:0002230 - positive regulation of defense response to virus by host
GO:0005739 - mitochondrion
GO:0016020 - membrane
GO:0032728 - positive regulation of interferon-beta production
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 608
Hs

1 732
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024