Protein: SSN8
RNA polymerase II holoenzyme cyclin-like subunit (Suppressor of RNA polymerase B 11)

Gene: SSN8
Organism: Saccharomyces cerevisiae S288C
Interactions: 81
UniProt ID: P47821

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000411 - positive regulation of transcription by galactose
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0005634 - nucleus
GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

810653

SSN3
Meiotic mRNA stability protein kinase SSN3

15

20

Small-scale

0.987

High

448759

SNF1
Carbon catabolite-derepressing protein kinase

2

0

Small-scale

0.791

High

440856

KIN28
Serine/threonine-protein kinase KIN28

2

20

Small-scale

0.781

High

602550

PHO85
Cyclin-dependent protein kinase PHO85

2

20

Small-scale

0.778

High

867858

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

6

Small-scale

0.747

High

678813

SRB8
Mediator of RNA polymerase II transcription subunit 12

6

7

Small-scale

0.735

High

807825

SSN2
Mediator of RNA polymerase II transcription subunit 13

7

0

Small-scale

0.715

High

584377

GCN2
eIF-2-alpha kinase GCN2

1

4

High-throughput

0.691

High

656533

KC11
Casein kinase I homolog 1

1

8

High-throughput

0.691

High

733549

MED16
Mediator of RNA polymerase II transcription subunit 16

3

0

High-throughput

0.616

High

867852

MED5
Mediator of RNA polymerase II transcription subunit 5

3

0

High-throughput

0.616

High

619436

MED14
Mediator of RNA polymerase II transcription subunit 14

2

2

High-throughput

0.601

High

740807

MED18
Mediator of RNA polymerase II transcription subunit 18

2

0

Small-scale

0.595

High

867862

MED10
Mediator of RNA polymerase II transcription subunit 10

2

2

Small-scale

0.595

High

408425

GAL4
Regulatory protein GAL4

2

3

Small-scale

0.594

High

524462

HSP71
Heat shock protein SSA1

2

8

Small-scale

0.571

High

757588

MED20
Mediator of RNA polymerase II transcription subunit 20

2

0

Small-scale

0.569

High

740465

MED22
Mediator of RNA polymerase II transcription subunit 22

2

0

High-throughput

0.563

High

545459

SSB1
Ribosome-associated molecular chaperone SSB1

2

7

High-throughput

0.552

High

761126

NOT4
General negative regulator of transcription subunit 4

1

0

Small-scale

0.537

High

633486

PP11
Serine/threonine-protein phosphatase PP1-1

1

7

High-throughput

0.536

High

867851

MDS3
Negative regulator of sporulation MDS3

1

1

High-throughput

0.536

High

726229

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

2

1

Small-scale

0.535

High

694229

BUD14
Bud site selection protein 14

1

0

High-throughput

0.518

High

438154

NOT2
General negative regulator of transcription subunit 2

1

2

Small-scale

0.515

High

628337

SFL1
Flocculation suppression protein

1

1

Small-scale

0.515

High

416894

CDC25
Cell division control protein 25

1

0

High-throughput

0.513

High

452746

ADR1
Regulatory protein ADR1

1

0

High-throughput

0.513

High

828490

SA185
SIT4-associating protein SAP185

1

0

High-throughput

0.513

High

864226

MDV1
Mitochondrial division protein 1

1

5

Small-scale

0.504

High

867847

ASK10
Activator of SKN7 protein 10

1

1

Small-scale

0.504

High

711504

BEM1
Bud emergence protein 1

1

5

High-throughput

0.494

High

778998

MYO3
Myosin-3

1

2

High-throughput

0.494

High

864725

BBC1
Myosin tail region-interacting protein MTI1

1

7

High-throughput

0.494

High

867861

MYO5
Myosin-5

1

2

High-throughput

0.494

High

678978

NOT1
General negative regulator of transcription subunit 1

1

0

Small-scale

0.493

High

744085

PMD1
Negative regulator of sporulation PMD1

1

1

High-throughput

0.489

High

792419

BOI1
BEM1-interacting protein 1

1

4

High-throughput

0.489

High

867854

YG5B
Uncharacterized RNA-binding protein YGR250C

1

4

High-throughput

0.489

High

752976

IXR1
Intrastrand cross-link recognition protein

1

4

Small-scale

0.481

High

481674

HSP73
Heat shock protein SSA3

1

8

Small-scale

0.479

High

579696

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.479

High

598417

TUP1
General transcriptional corepressor TUP1

1

5

Small-scale

0.479

High

624925

MED15
Mediator of RNA polymerase II transcription subunit 15

1

1

High-throughput

0.479

High

740421

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.479

High

797711

MED8
Mediator of RNA polymerase II transcription subunit 8

1

1

High-throughput

0.479

High

804027

MED6
Mediator of RNA polymerase II transcription subunit 6

1

2

High-throughput

0.479

High

867865

MED7
Mediator of RNA polymerase II transcription subunit 7

1

3

High-throughput

0.479

High

738669

EI2BB
Translation initiation factor eIF2B subunit beta

1

4

High-throughput

0.464

High

668278

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.458

High

668495

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.458

High

751213

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.458

High

823218

MED3
Mediator of RNA polymerase II transcription subunit 3

1

0

High-throughput

0.458

High

867846

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.458

High

867848

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.458

High

867866

MED2
Mediator of RNA polymerase II transcription subunit 2

1

0

High-throughput

0.458

High

867867

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

High-throughput

0.458

High

867868

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

867870

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

392993

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.445

High

403566

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

3

High-throughput

0.445

High

527093

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

676138

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.445

High

804281

SSZ1
Ribosome-associated complex subunit SSZ1

1

4

High-throughput

0.445

High

819187

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

867859

GCN5
Histone acetyltransferase GCN5

1

19

High-throughput

0.445

High

867850

APC10
Anaphase-promoting complex subunit DOC1

1

4

High-throughput

0.439

High

812838

ACON2
Homocitrate dehydratase, mitochondrial

1

3

High-throughput

0.437

High

836293

BNI1
Protein BNI1

1

1

High-throughput

0.437

High

867849

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

High-throughput

0.437

High

826452

DJP1
DnaJ-like protein 1

1

3

High-throughput

0.407

High

867856

APP1
Phosphatidate phosphatase APP1

2

0

High-throughput

0.314

High

867857

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.282

High

801073

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.279

Low

867860

GIS4
Protein GIS4

1

0

High-throughput

0.279

Low

867863

PIG1
Serine/threonine-protein phosphatase 1 regulatory subunit PIG1

1

0

High-throughput

0.279

Low

624777

PMA2
Plasma membrane ATPase 2

1

0

High-throughput

0.249

Low

867864

HBT1
Protein HBT1

1

0

High-throughput

0.249

Low

867869

PST1
Cell wall mannoprotein PST1

1

0

High-throughput

0.249

Low

867853

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

0

High-throughput

0.238

Low

867855

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025