HitPredict

Interactor 1: UFL1 (O94874)
E3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1) (Multiple alpha-helix protein located at ER) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1)
Gene: UFL1

Interactor 2: DDRGK (Q96HY6)
DDRGK domain-containing protein 1 (Dashurin) (UFM1-binding and PCI domain-containing protein 1)
Gene: DDRGK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

The method score is based on:

Property	Details
Experiments	32545848, 32807901, 26186194, 28514442, 32160526, 33961781, 37595036
Identification Methods	two hybrid, pull down, enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0008284 - positive regulation of cell population proliferation GO:0033146 - regulation of intracellular estrogen receptor signaling pathway and 6 others more... GO:0034976 - response to endoplasmic reticulum stress GO:0043066 - negative regulation of apoptotic process GO:0061709 - reticulophagy GO:0071569 - protein ufmylation GO:1903895 - negative regulation of IRE1-mediated unfolded protein response GO:1990592 - protein K69-linked ufmylation
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	794
Hs

1	314

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024