HitPredict

Interactor 1: SUN1 (O94901)
SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1)
Gene: SUN1

Interactor 2: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	34079125, 33961781, 32344865, 24375709
Identification Methods	proximity labelling technology, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005635 - nuclear envelope GO:0031965 - nuclear membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 785 Hs			1 664
+	Hs
		299633 SUN1_HUMAN (1-785): 0: 1166: 100.00		LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37
+	Hs
		360515 SUN2_HUMAN (241-783): 1.18e-178: 531: 36.24		LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00
+	Mm
		821719 SUN2_MOUSE (236-783): 6.8e-180: 535: 34.25		LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90
+	Hs
		595461 SUN2_HUMAN (241-783): 1.18e-178: 531: 36.24		LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37
+	Mm
		821739 SUN1_MOUSE (1-245): 1.05e-107: 352: 62.60		LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90
+	Ce
		1093999 SUN1_CAEEL (490-784): 3.83e-85: 280: 18.03		LMN1_CAEEL (1-539): 1.07e-53: 195: 29.49
+	Ce
		1093935 UNC84_CAEEL (547-785): 4.44e-69: 248: 38.68		LMN1_CAEEL (1-539): 1.07e-53: 195: 29.49