Protein: S6A12
Sodium- and chloride-dependent betaine transporter (BGT-1) (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12)

Gene: S6A12, SLC6A12
Organism: Homo sapiens
Interactions: 196
UniProt ID: P48065

Gene Ontology (top 5):
GO:0005332 - gamma-aminobutyric acid:sodium:chloride symporter activity
GO:0005886 - plasma membrane
GO:0006865 - amino acid transport
GO:0008028 - monocarboxylic acid transmembrane transporter activity
GO:0015171 - amino acid transmembrane transporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

549743

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.580

High

870231

SCRIB
Protein scribble homolog

2

10

Small-scale

0.576

High

869560

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

9

High-throughput

0.575

High

870211

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

9

High-throughput

0.575

High

870243

CD276
CD276 antigen

1

0

High-throughput

0.546

High

870291

ERBIN
Erbin

1

5

Small-scale

0.527

High

193689

TPSN
Tapasin

1

3

High-throughput

0.514

High

48553

ESYT2
Extended synaptotagmin-2

1

7

High-throughput

0.445

High

50510

HACL2
2-hydroxyacyl-CoA lyase 2

1

2

High-throughput

0.445

High

65451

TLCD2
TLC domain-containing protein 2

1

3

High-throughput

0.445

High

127299

LEG8
Galectin-8

1

8

High-throughput

0.445

High

161202

EI24
Etoposide-induced protein 2.4 homolog

1

5

High-throughput

0.445

High

178920

SCAM2
Secretory carrier-associated membrane protein 2

1

3

High-throughput

0.445

High

181278

PGRC2
Membrane-associated progesterone receptor component 2

1

4

High-throughput

0.445

High

184140

RER1
Protein RER1

1

2

High-throughput

0.445

High

184407

SURF4
Surfeit locus protein 4

1

4

High-throughput

0.445

High

186413

TM9S1
Transmembrane 9 superfamily member 1

1

7

High-throughput

0.445

High

212559

GPAA1
GPI-anchor transamidase component GPAA1

1

1

High-throughput

0.445

High

226313

SNG1
Synaptogyrin-1

1

3

High-throughput

0.445

High

226418

SNG2
Synaptogyrin-2

1

3

High-throughput

0.445

High

230769

EXTL3
Exostosin-like 3

1

1

High-throughput

0.445

High

248570

FADS1
Acyl-CoA

1

3

High-throughput

0.445

High

261122

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.445

High

295912

SC5D
Lathosterol oxidase

1

1

High-throughput

0.445

High

327192

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.445

High

338591

AGRL2
Adhesion G protein-coupled receptor L2

1

4

High-throughput

0.445

High

341405

CDS2
Phosphatidate cytidylyltransferase 2

1

3

High-throughput

0.445

High

344460

STR3N
STARD3 N-terminal-like protein

1

3

High-throughput

0.445

High

354098

CLPT1
Putative lipid scramblase CLPTM1

1

7

High-throughput

0.445

High

373829

RASN
GTPase NRas

1

20

High-throughput

0.445

High

374459

RASH
GTPase HRas

1

19

High-throughput

0.445

High

417310

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

3

High-throughput

0.445

High

418003

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.445

High

471628

CY1
Cytochrome c1, heme protein, mitochondrial

1

1

High-throughput

0.445

High

475917

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

3

High-throughput

0.445

High

483887

HMOX1
Heme oxygenase 1

1

2

High-throughput

0.445

High

522618

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

6

High-throughput

0.445

High

548436

MPRI
Cation-independent mannose-6-phosphate receptor

1

2

High-throughput

0.445

High

596619

NCPR
NADPH--cytochrome P450 reductase

1

4

High-throughput

0.445

High

609620

LEG3
Galectin-3

1

8

High-throughput

0.445

High

627283

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

3

High-throughput

0.445

High

656070

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

High-throughput

0.445

High

658867

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

6

High-throughput

0.445

High

661238

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

3

High-throughput

0.445

High

693393

CERS1
Ceramide synthase 1

1

13

High-throughput

0.445

High

719878

HMOX2
Heme oxygenase 2

1

2

High-throughput

0.445

High

789873

FDFT
Squalene synthase

1

1

High-throughput

0.445

High

813027

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

2

High-throughput

0.445

High

863434

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

1

High-throughput

0.445

High

870212

PSN2
Presenilin-2

1

1

High-throughput

0.445

High

870213

RAB5C
Ras-related protein Rab-5C

1

13

High-throughput

0.445

High

870215

DGKE
Diacylglycerol kinase epsilon

1

7

High-throughput

0.445

High

870219

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.445

High

870220

RAB5B
Ras-related protein Rab-5B

1

16

High-throughput

0.445

High

870221

RAP1A
Ras-related protein Rap-1A

1

16

High-throughput

0.445

High

870222

AT2C1
Calcium-transporting ATPase type 2C member 1

1

5

High-throughput

0.445

High

870224

CAV1
Caveolin-1

1

3

High-throughput

0.445

High

870226

KDSR
3-ketodihydrosphingosine reductase

1

10

High-throughput

0.445

High

870227

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

8

High-throughput

0.445

High

870228

LMAN2
Vesicular integral-membrane protein VIP36

1

2

High-throughput

0.445

High

870229

PTK7
Inactive tyrosine-protein kinase 7

1

7

High-throughput

0.445

High

870230

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

6

High-throughput

0.445

High

870232

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

3

High-throughput

0.445

High

870235

TMED2
Transmembrane emp24 domain-containing protein 2

1

3

High-throughput

0.445

High

870236

EPHA7
Ephrin type-A receptor 7

1

6

High-throughput

0.445

High

870237

DHC24
Delta(24)-sterol reductase

1

4

High-throughput

0.445

High

870238

TRAM1
Translocating chain-associated membrane protein 1

1

13

High-throughput

0.445

High

870239

MSMO1
Methylsterol monooxygenase 1

1

1

High-throughput

0.445

High

870245

LMBD2
G-protein coupled receptor-associated protein LMBRD2

1

2

High-throughput

0.445

High

870246

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

12

High-throughput

0.445

High

870247

RETST
All-trans-retinol 13,14-reductase

1

1

High-throughput

0.445

High

870248

LCLT1
Lysocardiolipin acyltransferase 1

1

13

High-throughput

0.445

High

870250

QSOX2
Sulfhydryl oxidase 2

1

8

High-throughput

0.445

High

870251

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

1

High-throughput

0.445

High

870253

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

2

High-throughput

0.445

High

870258

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.445

High

870259

K2013
Uncharacterized protein KIAA2013

1

1

High-throughput

0.445

High

870260

AN13A
Ankyrin repeat domain-containing protein 13A

1

4

High-throughput

0.445

High

870262

GHDC
GH3 domain-containing protein

1

2

High-throughput

0.445

High

870263

ABD12
Lysophosphatidylserine lipase ABHD12

1

2

High-throughput

0.445

High

870265

PAR16
Protein mono-ADP-ribosyltransferase PARP16

1

1

High-throughput

0.445

High

870267

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.445

High

870268

ATAD1
Outer mitochondrial transmembrane helix translocase

1

3

High-throughput

0.445

High

870270

GOGA5
Golgin subfamily A member 5

1

7

High-throughput

0.445

High

870272

DJB14
DnaJ homolog subfamily B member 14

1

6

High-throughput

0.445

High

870273

SPP
Signal peptide peptidase

1

3

High-throughput

0.445

High

870274

PO210
Nuclear pore membrane glycoprotein 210

1

5

High-throughput

0.445

High

870277

LMBR1
Limb region 1 protein homolog

1

2

High-throughput

0.445

High

870280

TM9S4
Transmembrane 9 superfamily member 4

1

7

High-throughput

0.445

High

870281

CDS1
Phosphatidate cytidylyltransferase 1

1

3

High-throughput

0.445

High

870283

F241B
Protein FAM241B

1

1

High-throughput

0.445

High

870285

CERS2
Ceramide synthase 2

1

13

High-throughput

0.445

High

870286

TMX3
Protein disulfide-isomerase TMX3

1

4

High-throughput

0.445

High

870289

CLP1L
Lipid scramblase CLPTM1L

1

7

High-throughput

0.445

High

870290

DNJC1
DnaJ homolog subfamily C member 1

1

6

High-throughput

0.445

High

870292

SEC62
Translocation protein SEC62

1

3

High-throughput

0.445

High

870293

SORT
Sortilin

1

2

High-throughput

0.445

High

870294

CHP1
Calcineurin B homologous protein 1

1

4

High-throughput

0.445

High

870295

SGMR1
Sigma non-opioid intracellular receptor 1

1

3

High-throughput

0.445

High

870298

ESYT1
Extended synaptotagmin-1

1

6

High-throughput

0.445

High

870299

YIPF4
Protein YIPF4

1

2

High-throughput

0.445

High

870304

FUT8
Alpha-(1,6)-fucosyltransferase

1

2

High-throughput

0.445

High

870305

LNP
Endoplasmic reticulum junction formation protein lunapark

1

3

High-throughput

0.445

High

870306

YIPF3
Protein YIPF3

1

5

High-throughput

0.445

High

870311

AT133
Polyamine-transporting ATPase 13A3

1

5

High-throughput

0.445

High

870312

TMT1A
Thiol S-methyltransferase TMT1A

1

3

High-throughput

0.445

High

870313

CNNM2
Metal transporter CNNM2

1

2

High-throughput

0.445

High

870315

VEZA
Vezatin

1

1

High-throughput

0.445

High

870316

SEC12
Guanine nucleotide-exchange factor SEC12

1

2

High-throughput

0.445

High

870317

TM9S3
Transmembrane 9 superfamily member 3

1

7

High-throughput

0.445

High

870318

JPH1
Junctophilin-1

1

2

High-throughput

0.445

High

870319

GPC5C
G-protein coupled receptor family C group 5 member C

1

5

High-throughput

0.445

High

870322

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

13

High-throughput

0.445

High

870324

AIG1
Androgen-induced gene 1 protein

1

1

High-throughput

0.445

High

870326

OCAD1
OCIA domain-containing protein 1

1

3

High-throughput

0.445

High

870327

T161A
Transmembrane protein 161A

1

3

High-throughput

0.445

High

870334

SEC63
Translocation protein SEC63 homolog

1

6

High-throughput

0.445

High

870340

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

3

High-throughput

0.445

High

612927

EGR1
Early growth response protein 1

1

1

High-throughput

0.437

High

114614

TM250
Transmembrane protein 250

1

0

High-throughput

0.426

High

162173

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.426

High

336262

BRI3
Membrane protein BRI3

1

0

High-throughput

0.426

High

602201

TMM11
Transmembrane protein 11, mitochondrial

1

0

High-throughput

0.426

High

870223

GCNT1
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

1

0

High-throughput

0.426

High

870242

TM268
Transmembrane protein 268

1

0

High-throughput

0.426

High

870244

GL8D1
Glycosyltransferase 8 domain-containing protein 1

1

0

High-throughput

0.426

High

870252

DYM
Dymeclin

1

0

High-throughput

0.426

High

870256

IPRI
Inositol 1,4,5-trisphosphate receptor-interacting protein

1

0

High-throughput

0.426

High

870278

APH1B
Gamma-secretase subunit APH-1B

1

0

High-throughput

0.426

High

870297

ADPGK
ADP-dependent glucokinase

1

0

High-throughput

0.426

High

870300

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.426

High

870301

TMM43
Transmembrane protein 43

1

0

High-throughput

0.426

High

870302

LMF2
Lipase maturation factor 2

1

0

High-throughput

0.426

High

870309

GCP60
Golgi resident protein GCP60

1

0

High-throughput

0.426

High

870310

GOLP3
Golgi phosphoprotein 3

1

0

High-throughput

0.426

High

870320

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.426

High

870328

IMPA3
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

1

0

High-throughput

0.426

High

870332

RHCG
Ammonium transporter Rh type C

1

0

High-throughput

0.426

High

870333

DHCR7
7-dehydrocholesterol reductase

1

0

High-throughput

0.426

High

85351

GPHRA
Golgi pH regulator A

1

7

High-throughput

0.407

High

117719

S35U4
SLC35A4 upstream open reading frame protein

1

1

High-throughput

0.407

High

184817

SPTC1
Serine palmitoyltransferase 1

1

4

High-throughput

0.407

High

184973

SPTC2
Serine palmitoyltransferase 2

1

4

High-throughput

0.407

High

219284

B4GA1
Beta-1,4-glucuronyltransferase 1

1

2

High-throughput

0.407

High

270003

XYLK
Glycosaminoglycan xylosylkinase

1

1

High-throughput

0.407

High

280151

SC22B
Vesicle-trafficking protein SEC22b

1

1

High-throughput

0.407

High

299626

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

2

High-throughput

0.407

High

350533

CF047
Uncharacterized protein C6orf47

1

2

High-throughput

0.407

High

353925

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

1

High-throughput

0.407

High

611028

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

7

High-throughput

0.407

High

717398

PDIA3
Protein disulfide-isomerase A3

1

4

High-throughput

0.407

High

847381

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

2

High-throughput

0.407

High

870214

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

3

High-throughput

0.407

High

870216

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

2

High-throughput

0.407

High

870217

SYJ2B
Synaptojanin-2-binding protein

1

19

High-throughput

0.407

High

870218

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

1

High-throughput

0.407

High

870234

STAR3
StAR-related lipid transfer protein 3

1

3

High-throughput

0.407

High

870240

AG10A
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

1

1

High-throughput

0.407

High

870241

RABL3
Rab-like protein 3

1

13

High-throughput

0.407

High

870254

MAVS
Mitochondrial antiviral-signaling protein

1

1

High-throughput

0.407

High

870255

RETR3
Reticulophagy regulator 3

1

4

High-throughput

0.407

High

870261

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

1

3

High-throughput

0.407

High

870264

CERS5
Ceramide synthase 5

1

13

High-throughput

0.407

High

870266

FITM2
Acyl-coenzyme A diphosphatase FITM2

1

2

High-throughput

0.407

High

870269

GALT6
Polypeptide N-acetylgalactosaminyltransferase 6

1

8

High-throughput

0.407

High

870275

THEM6
Protein THEM6

1

4

High-throughput

0.407

High

870276

SCFD1
Sec1 family domain-containing protein 1

1

1

High-throughput

0.407

High

870279

SNX19
Sorting nexin-19

1

12

High-throughput

0.407

High

870282

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

4

High-throughput

0.407

High

870284

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

2

High-throughput

0.407

High

870287

FACR2
Fatty acyl-CoA reductase 2

1

1

High-throughput

0.407

High

870296

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

1

2

High-throughput

0.407

High

870303

TMED9
Transmembrane emp24 domain-containing protein 9

1

3

High-throughput

0.407

High

870307

5NT3A
Cytosolic 5'-nucleotidase 3A

1

3

High-throughput

0.407

High

870308

SNX25
Sorting nexin-25

1

12

High-throughput

0.407

High

870314

RN121
E3 ubiquitin ligase RNF121

1

2

High-throughput

0.407

High

870321

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

1

13

High-throughput

0.407

High

870325

NDUBB
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

1

1

High-throughput

0.407

High

870329

ELOV2
Very long chain fatty acid elongase 2

1

2

High-throughput

0.407

High

870330

CNIH4
Protein cornichon homolog 4

1

4

High-throughput

0.407

High

870336

TMX2
Thioredoxin-related transmembrane protein 2

1

1

High-throughput

0.407

High

870337

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

2

High-throughput

0.407

High

870338

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.407

High

870339

SNX13
Sorting nexin-13

1

12

High-throughput

0.407

High

870341

S23IP
SEC23-interacting protein

1

3

High-throughput

0.407

High

870225

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.299

High

127465

NDUS8
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

1

0

High-throughput

0.232

Low

399668

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

0

High-throughput

0.232

Low

870233

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.232

Low

870249

DRAM2
DNA damage-regulated autophagy modulator protein 2

1

0

High-throughput

0.232

Low

870257

SGPP2
Sphingosine-1-phosphate phosphatase 2

1

0

High-throughput

0.232

Low

870271

PIGX
GPI alpha-1,4-mannosyltransferase I, stabilizing subunit

1

0

High-throughput

0.232

Low

870288

RN170
E3 ubiquitin-protein ligase RNF170

1

0

High-throughput

0.232

Low

870323

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.232

Low

870331

STX18
Syntaxin-18

1

0

High-throughput

0.232

Low

870335

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025