HitPredict

Interactor 1: CDK14 (O94921)
Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1)
Gene: CDK14

Interactor 2: CCND3 (P30281)
G1/S-specific cyclin-D3
Gene: CCND3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.766

Property	Details
Experiments	17517622
Identification Methods	two hybrid, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0004693 - cyclin-dependent protein serine/threonine kinase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 2 others more... GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 469 Hs			1 292
+	Hs
		622358 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86
+	Hs
		622427 CDK3_HUMAN (132-442): 4.46e-138: 400: 50.48		CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86
+	Hs
		625350 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		CCNA1_HUMAN (4-283): 4.44e-93: 284: 25.89
+	Hs
		538471 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		CCNB1_HUMAN (10-285): 8.22e-89: 272: 23.02
+	Hs
		590125 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		CCNA2_HUMAN (1-283): 1.9e-87: 269: 25.61
+	Hs
		625156 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		CCND3_HUMAN (1-292): 8.61e-89: 267: 100.00
+	Hs
		538521 CDK3_HUMAN (132-442): 4.46e-138: 400: 50.48		CCNB1_HUMAN (10-285): 8.22e-89: 272: 23.02
+	Hs
		303829 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		CCNB2_HUMAN (2-285): 2.8e-84: 260: 22.38
+	Hs
		590162 CDK3_HUMAN (132-442): 4.46e-138: 400: 50.48		CCNA2_HUMAN (1-283): 1.9e-87: 269: 25.61
+	Hs
		673140 CDK3_HUMAN (132-442): 4.46e-138: 400: 50.48		CCND3_HUMAN (1-292): 8.61e-89: 267: 100.00
+	Hs
		625155 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		CCND2_HUMAN (1-292): 1.54e-81: 249: 61.15
+	Hs
		673144 CDK18_HUMAN (3-466): 7.76e-132: 391: 45.69		CCND3_HUMAN (1-292): 8.61e-89: 267: 100.00
+	Rn
		981205 Q6P751_RAT (132-429): 1.4e-141: 409: 51.00		CCND2_RAT (1-292): 2.34e-80: 246: 60.47
+	Hs
		303844 CDK17_HUMAN (5-466): 3.99e-131: 391: 43.75		CCNB2_HUMAN (2-285): 2.8e-84: 260: 22.38
+	Mm
		629211 CDK2_MOUSE (132-429): 1.63e-132: 388: 43.97		CCND1_MOUSE (2-292): 1.72e-85: 259: 51.86
+	Hs
		331629 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		CCNE2_HUMAN (13-243): 1.83e-18: 86.7: 27.47
+	Hs
		625523 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		Q8WUE3_HUMAN (13-243): 2.15e-18: 85.9: 27.47
+	Hs
		624539 CDK2_HUMAN (132-429): 1.34e-141: 409: 50.67		CCNE1_HUMAN (14-208): 1.34e-15: 78.2: 29.13
+	Hs
		331637 CDK3_HUMAN (132-442): 4.46e-138: 400: 50.48		CCNE2_HUMAN (13-243): 1.83e-18: 86.7: 27.47
+	Hs
		624573 CDK3_HUMAN (132-442): 4.46e-138: 400: 50.48		CCNE1_HUMAN (14-208): 1.34e-15: 78.2: 29.13