Protein: BRE1B
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)

Gene: BRE1B, RNF40
Organism: Homo sapiens
Interactions: 203
UniProt ID: O75150

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003730 - mRNA 3'-UTR binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006325 - chromatin organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

256227

UBE2A
Ubiquitin-conjugating enzyme E2 A

6

16

Small-scale

0.944

High

256239

UBE2B
Ubiquitin-conjugating enzyme E2 B

4

16

Small-scale

0.888

High

256296

Q7KZS0
SUMO-conjugating enzyme UBC9

2

17

High-throughput

0.789

High

256280

BRE1A
E3 ubiquitin-protein ligase BRE1A

15

19

Small-scale

0.762

High

256240

UBC9
SUMO-conjugating enzyme UBC9

2

19

High-throughput

0.754

High

256334

WAC
WW domain-containing adapter protein with coiled-coil

4

5

Small-scale

0.708

High

256245

NCBP1
Nuclear cap-binding protein subunit 1

4

2

High-throughput

0.700

High

256198

P53
Cellular tumor antigen p53

5

6

Small-scale

0.699

High

256207

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

12

High-throughput

0.691

High

256268

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

14

High-throughput

0.691

High

256349

DISC1
Disrupted in schizophrenia 1 protein

4

6

High-throughput

0.691

High

256371

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

4

12

Small-scale

0.691

High

256208

ANDR
Androgen receptor

4

19

Small-scale

0.676

High

256344

DSN1
Kinetochore-associated protein DSN1 homolog

3

2

High-throughput

0.667

High

256186

BRE1B
E3 ubiquitin-protein ligase BRE1B

3

18

Small-scale

0.660

High

256269

H2B2E
Histone H2B type 2-E

3

20

Small-scale

0.651

High

256229

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

13

Small-scale

0.647

High

256237

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

13

High-throughput

0.647

High

204259

MS18B
Protein Mis18-beta

3

0

High-throughput

0.638

High

256301

MORC1
MORC family CW-type zinc finger protein 1

3

0

High-throughput

0.638

High

256193

NOE2
Noelin-2

2

2

High-throughput

0.628

High

256250

MED21
Mediator of RNA polymerase II transcription subunit 21

2

1

High-throughput

0.628

High

256312

TCP1L
T-complex protein 10A homolog 1

2

1

High-throughput

0.628

High

256314

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

2

11

High-throughput

0.628

High

256342

TX13A
Testis-expressed protein 13A

2

1

High-throughput

0.628

High

256361

ZN232
Zinc finger protein 232

2

3

High-throughput

0.628

High

159005

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

14

Small-scale

0.618

High

226032

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.618

High

256362

TRI33
E3 ubiquitin-protein ligase TRIM33

1

14

High-throughput

0.618

High

256365

AMOL2
Angiomotin-like protein 2

3

16

High-throughput

0.616

High

256305

SFR1
Swi5-dependent recombination DNA repair protein 1 homolog

2

0

High-throughput

0.616

High

256258

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

6

High-throughput

0.611

High

256283

VIR
Protein virilizer homolog

2

6

High-throughput

0.611

High

256192

SNP29
Synaptosomal-associated protein 29

3

1

High-throughput

0.609

High

256358

IL36A
Interleukin-36 alpha

3

1

High-throughput

0.609

High

256282

DUS29
Dual specificity phosphatase 29

2

7

High-throughput

0.606

High

256290

ZCH12
Zinc finger CCHC domain-containing protein 12

2

1

High-throughput

0.606

High

256222

HD
Huntingtin

2

4

High-throughput

0.596

High

256310

SIR6
NAD-dependent protein deacylase sirtuin-6

2

8

Small-scale

0.584

High

256231

KIF11
Kinesin-like protein KIF11

1

4

Small-scale

0.578

High

256292

INSY2
Inhibitory synaptic factor 2A

2

1

High-throughput

0.574

High

256304

SNX32
Sorting nexin-32

2

1

High-throughput

0.574

High

256329

NELL2
Protein kinase C-binding protein NELL2

2

4

High-throughput

0.574

High

256339

NUP58
Nucleoporin p58/p45

2

1

High-throughput

0.574

High

256366

COG6
Conserved oligomeric Golgi complex subunit 6

2

1

High-throughput

0.574

High

256368

WASC3
WASH complex subunit 3

2

1

High-throughput

0.574

High

256249

ATM
Serine-protein kinase ATM

1

9

Small-scale

0.561

High

256266

STX1A
Syntaxin-1A

1

2

Small-scale

0.561

High

256204

FCG3A
Low affinity immunoglobulin gamma Fc region receptor III-A

2

5

High-throughput

0.558

High

256293

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.553

High

256286

CDC73
Parafibromin

1

4

Small-scale

0.552

High

256201

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.549

High

256233

PKNX1
Homeobox protein PKNOX1

1

4

High-throughput

0.541

High

256333

TRI51
Tripartite motif-containing protein 51

1

5

High-throughput

0.541

High

256370

ZN451
E3 SUMO-protein ligase ZNF451

1

1

High-throughput

0.541

High

256217

EF1D
Elongation factor 1-delta

1

4

Small-scale

0.536

High

256219

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.536

High

147684

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

3

High-throughput

0.536

High

202005

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

8

High-throughput

0.536

High

209362

PLRG1
Pleiotropic regulator 1

1

13

High-throughput

0.536

High

256188

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

11

High-throughput

0.536

High

256206

TFPT
TCF3 fusion partner

1

1

High-throughput

0.536

High

256210

BIP
Endoplasmic reticulum chaperone BiP

1

10

High-throughput

0.536

High

256212

DDX5
Probable ATP-dependent RNA helicase DDX5

1

7

High-throughput

0.536

High

256215

S100P
Protein S100-P

1

18

High-throughput

0.536

High

256220

NUP62
Nuclear pore glycoprotein p62

1

12

High-throughput

0.536

High

256223

MAGA9
Melanoma-associated antigen 9

1

5

High-throughput

0.536

High

256224

NOTC1
Neurogenic locus notch homolog protein 1

1

3

High-throughput

0.536

High

256242

ERH
Enhancer of rudimentary homolog

1

1

High-throughput

0.536

High

256248

SRSF9
Serine/arginine-rich splicing factor 9

1

14

High-throughput

0.536

High

256253

SAFB2
Scaffold attachment factor B2

1

13

High-throughput

0.536

High

256255

ZN460
Zinc finger protein 460

1

1

High-throughput

0.536

High

256257

FL2D
Pre-mRNA-splicing regulator WTAP

1

1

High-throughput

0.536

High

256260

RNPS1
RNA-binding protein with serine-rich domain 1

1

11

High-throughput

0.536

High

256261

SAFB1
Scaffold attachment factor B1

1

11

High-throughput

0.536

High

256264

PKN1
Serine/threonine-protein kinase N1

1

6

High-throughput

0.536

High

256274

ZN326
DBIRD complex subunit ZNF326

1

2

High-throughput

0.536

High

256277

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

19

High-throughput

0.536

High

256278

SYT6
Synaptotagmin-6

1

3

High-throughput

0.536

High

256279

CE350
Centrosome-associated protein 350

1

19

High-throughput

0.536

High

256287

PRP8
Pre-mRNA-processing-splicing factor 8

1

3

High-throughput

0.536

High

256288

KLC3
Kinesin light chain 3

1

2

High-throughput

0.536

High

256298

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

4

High-throughput

0.536

High

256300

THOC4
THO complex subunit 4

1

7

High-throughput

0.536

High

256303

ZCH18
Zinc finger CCCH domain-containing protein 18

1

14

High-throughput

0.536

High

256307

RB12B
RNA-binding protein 12B

1

18

High-throughput

0.536

High

256315

CTBL1
Beta-catenin-like protein 1

1

1

High-throughput

0.536

High

256317

MGN2
Protein mago nashi homolog 2

1

2

High-throughput

0.536

High

256319

PF21B
PHD finger protein 21B

1

20

High-throughput

0.536

High

256320

THOC1
THO complex subunit 1

1

1

High-throughput

0.536

High

256323

YTDC1
YTH domain-containing protein 1

1

1

High-throughput

0.536

High

256326

IWS1
Protein IWS1 homolog

1

6

High-throughput

0.536

High

256327

RBM15
RNA-binding protein 15

1

9

High-throughput

0.536

High

256328

MINT
Msx2-interacting protein

1

11

High-throughput

0.536

High

256337

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

15

High-throughput

0.536

High

256348

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.536

High

256352

RBM12
RNA-binding protein 12

1

17

High-throughput

0.536

High

256355

BCLF1
Bcl-2-associated transcription factor 1

1

12

High-throughput

0.536

High

256356

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

4

High-throughput

0.536

High

256360

PRP19
Pre-mRNA-processing factor 19

1

14

High-throughput

0.536

High

256367

TR150
Thyroid hormone receptor-associated protein 3

1

14

High-throughput

0.536

High

256372

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

1

High-throughput

0.536

High

256373

RBM8A
RNA-binding protein 8A

1

8

High-throughput

0.536

High

256308

CC146
Coiled-coil domain-containing protein 146

1

16

High-throughput

0.523

High

256213

PRS6A
26S proteasome regulatory subunit 6A

1

6

High-throughput

0.515

High

256187

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.513

High

256254

FA50A
Protein FAM50A

1

0

High-throughput

0.513

High

256259

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.513

High

256276

SNPC4
snRNA-activating protein complex subunit 4

1

0

High-throughput

0.513

High

256285

THOC7
THO complex subunit 7 homolog

1

0

High-throughput

0.513

High

256294

TF2H5
General transcription factor IIH subunit 5

1

0

High-throughput

0.513

High

256324

CC115
Coiled-coil domain-containing protein 115

1

0

High-throughput

0.513

High

256330

T22D3
TSC22 domain family protein 3

1

0

High-throughput

0.513

High

256341

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.513

High

256369

SKAP
Small kinetochore-associated protein

1

0

High-throughput

0.513

High

256199

H2A1B
Histone H2A type 1-B/E

1

18

Small-scale

0.501

High

256281

MSL1
Male-specific lethal 1 homolog

1

1

Small-scale

0.501

High

256189

KRT38
Keratin, type I cuticular Ha8

1

16

High-throughput

0.489

High

256205

ITA5
Integrin alpha-5

1

3

High-throughput

0.489

High

256216

G0S2
G0/G1 switch protein 2

1

1

High-throughput

0.489

High

256271

CF184
Cilia- and flagella-associated protein 184

1

1

High-throughput

0.489

High

256272

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

256309

SYCE1
Synaptonemal complex central element protein 1

1

1

High-throughput

0.489

High

256313

BRK1
Protein BRICK1

1

2

High-throughput

0.489

High

256325

CC85A
Coiled-coil domain-containing protein 85A

1

1

High-throughput

0.489

High

256331

KXDL1
KxDL motif-containing protein 1

1

2

High-throughput

0.489

High

256338

BBLN
Bublin coiled-coil protein

1

1

High-throughput

0.489

High

256351

KRT82
Keratin, type II cuticular Hb2

1

5

High-throughput

0.489

High

256363

ANGP4
Angiopoietin-4

1

2

High-throughput

0.489

High

256374

WIF1
Wnt inhibitory factor 1

1

4

High-throughput

0.489

High

256228

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

256263

ITSN1
Intersectin-1

1

8

High-throughput

0.481

High

123804

SPT5H
Transcription elongation factor SPT5

1

6

High-throughput

0.479

High

148200

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.479

High

213997

SPOP
Speckle-type POZ protein

1

3

High-throughput

0.479

High

231902

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.479

High

243693

BRD4
Bromodomain-containing protein 4

1

9

High-throughput

0.479

High

246513

MCE1
mRNA-capping enzyme

1

5

High-throughput

0.479

High

256191

PARN
Poly(A)-specific ribonuclease PARN

1

1

High-throughput

0.479

High

256194

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.479

High

256196

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

256197

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.479

High

256200

PERM
Myeloperoxidase

1

2

High-throughput

0.479

High

256202

HS90A
Heat shock protein HSP 90-alpha

1

10

High-throughput

0.479

High

256203

HS90B
Heat shock protein HSP 90-beta

1

10

High-throughput

0.479

High

256230

NCBP2
Nuclear cap-binding protein subunit 2

1

10

High-throughput

0.479

High

256232

TERF1
Telomeric repeat-binding factor 1

1

4

High-throughput

0.479

High

256235

ISL1
Insulin gene enhancer protein ISL-1

1

5

Small-scale

0.479

High

256236

H4
Histone H4

1

12

High-throughput

0.479

High

256238

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

12

High-throughput

0.479

High

256241

TPM4
Tropomyosin alpha-4 chain

1

10

High-throughput

0.479

High

256243

HSF1
Heat shock factor protein 1

1

5

High-throughput

0.479

High

256244

EWS
RNA-binding protein EWS

1

4

High-throughput

0.479

High

256246

EP300
Histone acetyltransferase p300

1

13

High-throughput

0.479

High

256247

FOXC1
Forkhead box protein C1

1

7

High-throughput

0.479

High

256251

HDAC1
Histone deacetylase 1

1

15

High-throughput

0.479

High

256252

CUL4A
Cullin-4A

1

11

Small-scale

0.479

High

256256

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

4

High-throughput

0.479

High

256262

TERF2
Telomeric repeat-binding factor 2

1

4

High-throughput

0.479

High

256265

DDB1
DNA damage-binding protein 1

1

4

Small-scale

0.479

High

256267

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.479

High

256273

SMU1
WD40 repeat-containing protein SMU1

1

15

Small-scale

0.479

High

256289

FXL19
F-box/LRR-repeat protein 19

1

3

Small-scale

0.479

High

256295

SPT6H
Transcription elongation factor SPT6

1

3

Small-scale

0.479

High

256297

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

256299

ZN598
E3 ubiquitin-protein ligase ZNF598

1

9

High-throughput

0.479

High

256306

MIB1
E3 ubiquitin-protein ligase MIB1

1

2

High-throughput

0.479

High

256316

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

1

High-throughput

0.479

High

256318

PF21A
PHD finger protein 21A

1

17

High-throughput

0.479

High

256340

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

17

Small-scale

0.479

High

256343

COMD4
COMM domain-containing protein 4

1

1

Small-scale

0.479

High

256354

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

256357

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

256359

RCOR1
REST corepressor 1

1

5

High-throughput

0.479

High

256226

MTR1B
Melatonin receptor type 1B

1

2

High-throughput

0.464

High

256195

TRFL
Lactotransferrin

1

0

High-throughput

0.458

High

256221

TALDO
Transaldolase

1

0

High-throughput

0.458

High

256291

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

256302

SERC5
Serine incorporator 5

1

0

Small-scale

0.458

High

256335

IER2
Immediate early response gene 2 protein

1

0

High-throughput

0.458

High

256347

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

256350

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.458

High

256284

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.457

High

256209

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.445

High

256275

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

256364

NINL
Ninein-like protein

1

15

High-throughput

0.439

High

256336

CENPO
Centromere protein O

1

0

High-throughput

0.438

High

256190

RHBT1
Rho-related BTB domain-containing protein 1

1

17

High-throughput

0.437

High

256211

PDIA4
Protein disulfide-isomerase A4

1

8

High-throughput

0.437

High

256214

PRTN3
Myeloblastin

1

6

High-throughput

0.437

High

256218

MARCS
Myristoylated alanine-rich C-kinase substrate

1

4

Small-scale

0.437

High

256311

PKHO2
Pleckstrin homology domain-containing family O member 2

1

6

High-throughput

0.437

High

256332

ATGA1
Autophagy-related protein 101

1

2

Small-scale

0.437

High

256346

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

256270

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

2

High-throughput

0.407

High

256322

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.279

Low

256353

PDRG1
p53 and DNA damage-regulated protein 1

1

0

High-throughput

0.279

Low

1183

QCR6L
Cytochrome b-c1 complex subunit 6-like, mitochondrial

1

0

High-throughput

0.269

Low

256225

INAR2
Interferon alpha/beta receptor 2

1

0

Small-scale

0.249

Low

256234

WNT4
Protein Wnt-4

1

0

High-throughput

0.249

Low

256321

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.249

Low

256345

TRABD
TraB domain-containing protein

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024