HitPredict

Interactor 1: RNF37 (O94941)
RING finger protein 37 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF37) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (hUIP5) (Ubiquitin-conjugating enzyme 7-interacting protein 5)
Gene: UBOX5

Interactor 2: UB2L3 (P68036)
Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3)
Gene: UBE2L3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	11274149, 33961781, 19549727
Identification Methods	pull down, two hybrid, affinity chromatography technology, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	U-box~UQ_con, UQ_con~zf-RING_5
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 541 Hs			1 154
+	Hs
		301058 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93
+	Hs
		301042 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26
+	Hs
		301050 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Hs
		301047 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		301056 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2E2_HUMAN (2-149): 1.55e-68: 207: 34.90
+	Hs
		301043 RNF37_HUMAN (1-541): 0: 1014: 100.00		UB2E1_HUMAN (2-149): 6.55e-67: 203: 34.90
+	Mm
		932606 RNF37_MOUSE (1-541): 0: 981: 79.30		UB2L3_MOUSE (1-154): 1.26e-64: 196: 100.00