Protein: CIC1
Proteasome-interacting protein CIC1 (Core interacting component 1)

Gene: CIC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 232
UniProt ID: P38779

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000502 - proteasome complex
GO:0003723 - RNA binding
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

803922

HAS1
ATP-dependent RNA helicase HAS1

8

9

Small-scale

0.964

High

803868

NUG1
Nuclear GTP-binding protein NUG1

8

3

Small-scale

0.961

High

682270

SPB4
ATP-dependent rRNA helicase SPB4

7

6

High-throughput

0.956

High

803898

NOG2
Nucleolar GTP-binding protein 2

7

3

Small-scale

0.956

High

803971

DBP10
ATP-dependent RNA helicase DBP10

6

3

High-throughput

0.937

High

793473

MAK5
ATP-dependent RNA helicase MAK5

5

6

High-throughput

0.919

High

746622

DRS1
ATP-dependent RNA helicase DRS1

4

5

High-throughput

0.886

High

803855

CIC1
Proteasome-interacting protein CIC1

3

0

High-throughput

0.806

High

569777

RL30
Large ribosomal subunit protein eL30

2

1

High-throughput

0.789

High

803890

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

1

High-throughput

0.789

High

803940

DBP9
ATP-dependent RNA helicase DBP9

2

2

High-throughput

0.754

High

782323

RPF2
Ribosome biogenesis protein RPF2

11

3

Small-scale

0.754

High

803905

NOP15
Ribosome biogenesis protein 15

9

4

Small-scale

0.753

High

666449

DBP2
ATP-dependent RNA helicase DBP2

2

0

High-throughput

0.753

High

791052

NOP4
Nucleolar protein 4

8

4

Small-scale

0.751

High

803876

NOP2
25S rRNA

8

2

Small-scale

0.748

High

803964

YTM1
Ribosome biogenesis protein YTM1

8

6

Small-scale

0.746

High

803935

RRP5
rRNA biogenesis protein RRP5

7

1

High-throughput

0.745

High

803919

NOG1
Nucleolar GTP-binding protein 1

7

2

Small-scale

0.740

High

803875

RLP7
Ribosome biogenesis protein RLP7

6

3

High-throughput

0.731

High

803933

ERB1
Ribosome biogenesis protein ERB1

6

4

Small-scale

0.729

High

803968

MAK21
Ribosome biogenesis protein MAK21

6

4

High-throughput

0.729

High

803894

PESC
Pescadillo homolog

14

0

Small-scale

0.727

High

803891

NSA1
Ribosome biogenesis protein NSA1

6

1

Small-scale

0.726

High

803930

PUF6
Pumilio homology domain family member 6

6

1

Small-scale

0.724

High

803856

SSF1
Ribosome biogenesis protein SSF1

6

3

Small-scale

0.722

High

803924

ARX1
Probable metalloprotease ARX1

9

0

Small-scale

0.716

High

803863

NOC2
Nucleolar complex protein 2

7

0

Small-scale

0.712

High

750075

MRT4
Ribosome assembly factor MRT4

5

2

Small-scale

0.709

High

803878

UTP10
U3 small nucleolar RNA-associated protein 10

5

1

High-throughput

0.699

High

803965

NOP53
Ribosome biogenesis protein NOP53

5

2

Small-scale

0.699

High

803859

RIX1
Pre-rRNA-processing protein RIX1

6

0

Small-scale

0.697

High

780258

EBP2
rRNA-processing protein EBP2

4

2

High-throughput

0.694

High

154165

RL36B
Large ribosomal subunit protein eL36B

1

1

High-throughput

0.691

High

584229

MS116
ATP-dependent RNA helicase MSS116, mitochondrial

1

6

High-throughput

0.691

High

712559

RL8B
Large ribosomal subunit protein eL8B

1

2

High-throughput

0.691

High

585269

FBRL
rRNA 2'-O-methyltransferase fibrillarin

4

1

High-throughput

0.691

High

803951

BUD20
Bud site selection protein 20

5

0

Small-scale

0.688

High

803858

RPF1
Ribosome production factor 1

4

4

High-throughput

0.687

High

763067

RRP1
Ribosomal RNA-processing protein 1

4

2

Small-scale

0.686

High

803963

MDN1
Midasin

4

1

High-throughput

0.686

High

803973

NOP58
Nucleolar protein 58

4

5

High-throughput

0.686

High

637216

PWP1
Periodic tryptophan protein 1

3

5

High-throughput

0.658

High

410113

RL25
Large ribosomal subunit protein uL23

3

1

Small-scale

0.656

High

803902

IPI3
Pre-rRNA-processing protein IPI3

3

6

High-throughput

0.656

High

803903

NOP13
Nucleolar protein 13

3

1

High-throughput

0.656

High

803949

NOC3
Nucleolar complex-associated protein 3

3

3

High-throughput

0.656

High

803952

NOP12
Nucleolar protein 12

3

3

High-throughput

0.656

High

803953

BRX1
Ribosome biogenesis protein BRX1

3

15

High-throughput

0.656

High

803962

NIP7
60S ribosome subunit biogenesis protein NIP7

3

2

High-throughput

0.656

High

803974

IF6
Eukaryotic translation initiation factor 6

3

1

Small-scale

0.656

High

684713

RL5
Large ribosomal subunit protein uL18

5

1

Small-scale

0.652

High

803895

SDA1
Protein SDA1

4

0

Small-scale

0.643

High

803961

RRS1
Regulator of ribosome biosynthesis

3

2

High-throughput

0.643

High

633156

MAK11
Protein MAK11

3

5

Small-scale

0.640

High

673559

NLE1
Ribosome assembly protein 4

3

6

Small-scale

0.640

High

677196

SPB1
27S pre-rRNA

3

3

High-throughput

0.640

High

689023

RL16A
Large ribosomal subunit protein uL13A

3

2

High-throughput

0.640

High

751393

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

3

2

High-throughput

0.640

High

803869

NSA2
Ribosome biogenesis protein NSA2

3

1

Small-scale

0.640

High

803950

RLP24
Ribosome biogenesis protein RLP24

3

1

Small-scale

0.640

High

743200

PP12
Serine/threonine-protein phosphatase PP1-2

2

1

High-throughput

0.628

High

803857

IPI1
Pre-rRNA-processing protein IPI1

3

0

High-throughput

0.628

High

803879

LOC1
60S ribosomal subunit assembly/export protein LOC1

3

0

Small-scale

0.628

High

513495

RL1A
Large ribosomal subunit protein uL1A

1

1

High-throughput

0.618

High

601038

RL8A
Large ribosomal subunit protein eL8A

1

2

Small-scale

0.618

High

781619

DBP7
ATP-dependent RNA helicase DBP7

1

7

High-throughput

0.618

High

803882

MTR4
ATP-dependent RNA helicase DOB1

1

4

Small-scale

0.618

High

803897

DBP6
ATP-dependent RNA helicase DBP6

1

6

High-throughput

0.618

High

803926

DHR1
Probable ATP-dependent RNA helicase DHR1

1

3

High-throughput

0.618

High

803881

ALB1
Ribosome biogenesis protein ALB1

3

0

Small-scale

0.613

High

803925

RRP17
Ribosomal RNA-processing protein 17

3

0

High-throughput

0.613

High

570002

RL3
Large ribosomal subunit protein uL3

2

1

High-throughput

0.611

High

803904

NAT10
RNA cytidine acetyltransferase

2

1

High-throughput

0.611

High

803977

RRP12
Ribosomal RNA-processing protein 12

2

2

High-throughput

0.611

High

645402

XRN1
5'-3' exoribonuclease 1

2

1

High-throughput

0.594

High

460725

CDC4
Cell division control protein 4

1

5

Small-scale

0.586

High

534105

MAK16
Protein MAK16

2

2

High-throughput

0.584

High

745077

AFG2
ATPase family gene 2 protein

2

1

High-throughput

0.584

High

798205

ENP1
Essential nuclear protein 1

2

1

High-throughput

0.584

High

803915

RS15
Small ribosomal subunit protein uS19

2

2

High-throughput

0.584

High

803972

NOP56
Nucleolar protein 56

2

5

High-throughput

0.584

High

433197

RL17A
Large ribosomal subunit protein uL22A

2

1

High-throughput

0.571

High

670676

SIS1
Protein SIS1

2

1

High-throughput

0.571

High

803870

PSA4
Proteasome subunit alpha type-4

1

0

Small-scale

0.568

High

513361

RL23B
Large ribosomal subunit protein uL14B

2

0

Small-scale

0.559

High

758207

URB1
Nucleolar pre-ribosomal-associated protein 1

2

0

Small-scale

0.559

High

803867

NOP16
Nucleolar protein 16

2

0

High-throughput

0.559

High

803892

CGR1
rRNA-processing protein CGR1

2

0

Small-scale

0.559

High

803886

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.553

High

803936

HRQ1
ATP-dependent helicase HRQ1

1

3

Small-scale

0.553

High

803901

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

3

High-throughput

0.541

High

432568

RL7A
Large ribosomal subunit protein uL30A

1

3

High-throughput

0.536

High

585927

CSK21
Casein kinase II subunit alpha

1

2

High-throughput

0.536

High

622945

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.536

High

803888

RL4B
Large ribosomal subunit protein uL4B

1

2

High-throughput

0.536

High

803928

UTP15
U3 small nucleolar RNA-associated protein 15

1

6

High-throughput

0.536

High

803948

RIX7
Ribosome biogenesis ATPase RIX7

1

1

High-throughput

0.536

High

803975

RL13A
Large ribosomal subunit protein eL13A

1

1

High-throughput

0.536

High

503026

RS22A
Small ribosomal subunit protein uS8A

2

3

High-throughput

0.533

High

504195

RL31A
Large ribosomal subunit protein eL31A

2

2

High-throughput

0.533

High

803967

YRA1
RNA annealing protein YRA1

1

3

High-throughput

0.515

High

383303

RL28
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

434014

RL33A
Large ribosomal subunit protein eL33A

1

0

High-throughput

0.513

High

636659

PSA1
Proteasome subunit alpha type-1

1

0

Small-scale

0.513

High

721306

PSB7
Proteasome subunit beta type-7

1

0

Small-scale

0.513

High

750940

PRS7
26S proteasome regulatory subunit 7 homolog

1

0

Small-scale

0.513

High

781182

RL14A
Large ribosomal subunit protein eL14A

1

0

High-throughput

0.513

High

803947

NOP6
Nucleolar protein 6

1

0

High-throughput

0.513

High

518013

SSBP1
Single-stranded nucleic acid-binding protein

1

2

High-throughput

0.501

High

803913

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

1

High-throughput

0.489

High

803914

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.489

High

803920

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

2

High-throughput

0.489

High

803921

PKH3
Serine/threonine-protein kinase PKH3

1

1

High-throughput

0.489

High

803959

HRK1
Serine/threonine-protein kinase HRK1

1

1

High-throughput

0.489

High

149745

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

433623

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.479

High

435071

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

435945

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

441892

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

455046

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.479

High

512423

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

515251

RL35A
Large ribosomal subunit protein uL29A

1

1

High-throughput

0.479

High

673171

RRP7
Ribosomal RNA-processing protein 7

1

1

High-throughput

0.479

High

674605

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

677382

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.479

High

678386

PWP2
Periodic tryptophan protein 2

1

7

High-throughput

0.479

High

739358

ZUO1
Zuotin

1

3

Small-scale

0.479

High

763565

UTP20
U3 small nucleolar RNA-associated protein 20

1

1

High-throughput

0.479

High

778313

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

803860

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

2

High-throughput

0.479

High

803884

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

3

High-throughput

0.479

High

803893

UTP22
U3 small nucleolar RNA-associated protein 22

1

1

High-throughput

0.479

High

803896

YG5X
Putative methyltransferase YGR283C

1

1

High-throughput

0.479

High

803900

JJJ1
J protein JJJ1

1

2

Small-scale

0.479

High

803907

RCM1
25S rRNA

1

2

High-throughput

0.479

High

803918

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

803927

RRB1
Ribosome assembly protein RRB1

1

4

High-throughput

0.479

High

803931

UTP14
U3 small nucleolar RNA-associated protein 14

1

2

High-throughput

0.479

High

803938

FKBP4
FK506-binding protein 4

1

2

High-throughput

0.479

High

803939

JIP5
WD repeat-containing protein JIP5

1

7

High-throughput

0.479

High

803941

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

1

High-throughput

0.479

High

803944

NOC4
Nucleolar complex protein 4

1

4

High-throughput

0.479

High

803945

UTP4
U3 small nucleolar RNA-associated protein 4

1

8

High-throughput

0.479

High

803954

REXO4
RNA exonuclease 4

1

1

High-throughput

0.479

High

803960

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

803966

SSF2
Ribosome biogenesis protein SSF2

1

3

High-throughput

0.479

High

803970

UTP12
U3 small nucleolar RNA-associated protein 12

1

7

High-throughput

0.479

High

803978

NOP14
Nucleolar complex protein 14

1

2

High-throughput

0.479

High

514281

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.458

High

677925

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.458

High

689437

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

780672

RRP14
Ribosomal RNA-processing protein 14

1

0

High-throughput

0.458

High

795813

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

803864

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

Small-scale

0.458

High

803865

RS26A
Small ribosomal subunit protein eS26A

1

0

High-throughput

0.458

High

803872

BMT5
25S rRNA

1

0

High-throughput

0.458

High

803885

URB2
Nucleolar pre-ribosomal-associated protein 2

1

0

High-throughput

0.458

High

803943

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.458

High

803955

NOP8
60S ribosome subunit biogenesis protein NOP8

1

0

High-throughput

0.458

High

403502

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

2

High-throughput

0.457

High

427264

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.445

High

531727

RL4A
Large ribosomal subunit protein uL4A

1

2

High-throughput

0.445

High

544774

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

381092

H2B1
Histone H2B.1

1

1

High-throughput

0.437

High

382082

H4
Histone H4

1

1

High-throughput

0.437

High

383686

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

419722

H2A2
Histone H2A.2

1

1

High-throughput

0.437

High

436400

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.437

High

511191

RL20B
Large ribosomal subunit protein eL20B

1

1

High-throughput

0.437

High

512992

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

646392

RAD53
Serine/threonine-protein kinase RAD53

1

1

High-throughput

0.437

High

707016

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

708729

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.437

High

747346

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.437

High

752224

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.437

High

753353

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

792028

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.437

High

792512

RL32
Large ribosomal subunit protein eL32

1

1

High-throughput

0.437

High

803861

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

803871

ATAD2
ATPase histone chaperone YTA7

1

2

High-throughput

0.437

High

803874

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

803906

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.437

High

803909

H3
Histone H3

1

3

High-throughput

0.437

High

803932

POB3
FACT complex subunit POB3

1

3

High-throughput

0.437

High

803934

YM91
Putative methyltransferase YMR310C

1

1

High-throughput

0.437

High

803946

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

803969

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.437

High

803976

H2AZ
Histone H2A.Z

1

2

High-throughput

0.437

High

721257

PSB5
Proteasome subunit beta type-5

1

0

Small-scale

0.426

High

803889

RL9B
Large ribosomal subunit protein uL6B

1

0

High-throughput

0.426

High

803917

NU116
Nucleoporin NUP116/NSP116

1

0

Small-scale

0.426

High

510463

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.407

High

523856

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.407

High

675979

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.407

High

755090

GCN1
eIF-2-alpha kinase activator GCN1

1

3

High-throughput

0.407

High

803873

ULP2
Ubiquitin-like-specific protease 2

2

0

High-throughput

0.306

High

503786

RL27A
Large ribosomal subunit protein eL27A

2

0

High-throughput

0.305

High

803908

ORC1
Origin recognition complex subunit 1

2

0

Small-scale

0.305

High

448167

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.279

Low

721917

XPO1
Exportin-1

1

0

High-throughput

0.279

Low

803899

ELOA1
Elongin-A

1

0

High-throughput

0.279

Low

803911

AP1M1
AP-1 complex subunit mu-1-I

1

0

High-throughput

0.279

Low

803916

PVH1
Tyrosine-protein phosphatase YVH1

1

0

High-throughput

0.279

Low

803956

DNLI4
DNA ligase 4

1

0

High-throughput

0.279

Low

803958

DIA2
Protein DIA2

1

0

High-throughput

0.279

Low

803880

LSM1
LSM1-LSM7 complex subunit LSM1

1

0

High-throughput

0.269

Low

803912

REG1
Resistance to glucose repression protein 1

1

0

High-throughput

0.269

Low

415014

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.249

Low

448309

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.249

Low

477556

MYO1
Myosin-1

1

0

Small-scale

0.249

Low

502725

RS21A
Small ribosomal subunit protein eS21A

1

0

High-throughput

0.249

Low

511413

RL43B
Large ribosomal subunit protein eL43B

1

0

Small-scale

0.249

Low

647100

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

709740

BMH1
Protein BMH1

1

0

High-throughput

0.249

Low

734962

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

785918

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.249

Low

802152

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

803862

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.249

Low

803877

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.249

Low

803887

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.249

Low

803910

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

803923

PML39
Pre-mRNA leakage protein 39

1

0

High-throughput

0.249

Low

803929

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

803937

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

803942

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

803957

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

394529

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

453582

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

803866

BEM2
GTPase-activating protein BEM2/IPL2

1

0

High-throughput

0.232

Low

803883

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025