HitPredict

Interactor 1: AP2A2 (O94973)
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)
Gene: AP2A2

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	28190767, 38803224
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030666 - endocytic vesicle membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 939 Hs			1 685
+	Hs
		321470 AP2A1_HUMAN (1-939): 0: 832: 78.47		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475594 AP2B1_HUMAN (36-933): 0: 607: 16.62		UBC_HUMAN (1-685): 0: 846: 100.00
+	Zm
		111864 K7VAA4_MAIZE (1-821): 0: 605: 24.26		Q42415_MAIZE (229-685): 0: 548: 95.84
+	Mm
		476684 AP2A2_MOUSE (1-939): 0: 891: 96.70		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Rn
		1144175 Q66HM2_RAT (1-939): 0: 886: 96.28		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Hs
		302089 AP2A2_HUMAN (1-939): 0: 884: 100.00		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	At
		1091811 AP2A2_ARATH (8-939): 0: 714: 37.13		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Zm
		111863 K7VAA4_MAIZE (1-821): 0: 605: 24.26		Q41754_MAIZE (381-685): 3.03e-124: 375: 95.74
+	Mm
		476683 AP2A1_MOUSE (1-939): 0: 830: 79.33		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		321462 AP2A1_HUMAN (1-939): 0: 832: 78.47		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	At
		286688 APBLC_ARATH (36-935): 0: 589: 17.48		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		1092397 APBLB_ARATH (36-935): 0: 577: 16.83		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		1091731 AP1G1_ARATH (1-821): 0: 574: 23.38		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		1013363 COPG_ARATH (29-937): 0: 572: 14.10		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		1091782 AP4E_ARATH (11-658): 4.61e-163: 503: 22.01		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Mm
		477012 AP2B1_MOUSE (36-933): 0: 607: 16.51		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Rn
		923858 AP2B1_RAT (36-933): 0: 607: 16.62		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Hs
		397894 AP2B1_HUMAN (36-933): 0: 607: 16.62		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69