Protein: CNOT8
CCR4-NOT transcription complex subunit 8 (EC 3.1.13.4) (CAF1-like protein) (CALIFp) (CAF2) (CCR4-associated factor 8) (Caf1b)

Gene: CNOT8
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q9UFF9

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening
GO:0000932 - P-body
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

64142

CNOT1
CCR4-NOT transcription complex subunit 1

6

8

Small-scale

0.950

High

974908

BTG1
Protein BTG1

6

20

Small-scale

0.944

High

1008535

BTG2
Protein BTG2

2

20

Small-scale

0.837

High

897475

TOB1
Protein Tob1

2

20

High-throughput

0.811

High

1120431

TOB2
Protein Tob2

1

20

High-throughput

0.740

High

1397046

CNO6L
CCR4-NOT transcription complex subunit 6-like

5

13

Small-scale

0.713

High

1123546

BTG3
Protein BTG3

1

20

High-throughput

0.698

High

866855

CAZA2
F-actin-capping protein subunit alpha-2

4

3

High-throughput

0.691

High

1453503

CNOT2
CCR4-NOT transcription complex subunit 2

4

10

Small-scale

0.691

High

273945

CNOT3
CCR4-NOT transcription complex subunit 3

3

13

Small-scale

0.680

High

1459118

CNO11
CCR4-NOT transcription complex subunit 11

3

1

High-throughput

0.662

High

1439105

TNR6C
Trinucleotide repeat-containing gene 6C protein

3

8

Small-scale

0.656

High

867486

CAPZB
F-actin-capping protein subunit beta

3

1

High-throughput

0.650

High

275465

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

2

1

High-throughput

0.628

High

949507

NANO2
Nanos homolog 2

2

4

High-throughput

0.628

High

1438633

GPBL1
Vasculin-like protein 1

2

2

High-throughput

0.628

High

1436892

CNO10
CCR4-NOT transcription complex subunit 10

2

1

High-throughput

0.621

High

170404

AURKA
Aurora kinase A

2

1

High-throughput

0.611

High

915210

CAZA1
F-actin-capping protein subunit alpha-1

2

3

High-throughput

0.611

High

480392

MMP7
Matrilysin

3

1

High-throughput

0.609

High

1325727

RIBC1
RIB43A-like with coiled-coils protein 1

3

1

High-throughput

0.604

High

1336868

TNR6A
Trinucleotide repeat-containing gene 6A protein

2

6

Small-scale

0.601

High

1459120

TNR6B
Trinucleotide repeat-containing gene 6B protein

2

6

Small-scale

0.601

High

1129527

PUM1
Pumilio homolog 1

2

9

Small-scale

0.595

High

1233695

Q6IBC8
Protein BTG1

1

20

High-throughput

0.594

High

384576

CRYAA
Alpha-crystallin A chain

2

0

High-throughput

0.592

High

688332

TTP
mRNA decay activator protein ZFP36

2

6

Small-scale

0.584

High

1215878

RC3H1
Roquin-1

2

4

Small-scale

0.584

High

1310667

Z3H7A
Zinc finger CCCH domain-containing protein 7A

2

1

High-throughput

0.584

High

1459119

CNOT6
CCR4-NOT transcription complex subunit 6

2

13

Small-scale

0.576

High

1417396

TX13A
Testis-expressed protein 13A

2

1

High-throughput

0.574

High

397143

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

1407937

ANM1
Protein arginine N-methyltransferase 1

1

1

Small-scale

0.561

High

1399946

FACOS
FANCD2 opposite strand protein

2

1

High-throughput

0.549

High

64815

EPAB2
Embryonic polyadenylate-binding protein 2

1

2

High-throughput

0.536

High

302093

SEGN
Secretagogin

1

1

High-throughput

0.536

High

844053

HD
Huntingtin

1

2

High-throughput

0.536

High

848740

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.536

High

1123164

FHL2
Four and a half LIM domains protein 2

1

2

High-throughput

0.536

High

756396

MCM7
DNA replication licensing factor MCM7

1

1

High-throughput

0.515

High

838191

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

Small-scale

0.515

High

1459117

AGO2
Protein argonaute-2

1

6

Small-scale

0.515

High

486633

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

885718

CASP4
Caspase-4

1

0

High-throughput

0.513

High

340592

CNOT4
CCR4-NOT transcription complex subunit 4

1

3

Small-scale

0.501

High

1287142

PATL1
Protein PAT1 homolog 1

1

4

Small-scale

0.500

High

638544

FPR1
fMet-Leu-Phe receptor

1

1

High-throughput

0.489

High

1361408

NANO1
Nanos homolog 1

1

4

High-throughput

0.489

High

1364166

TM131
Transmembrane protein 131

1

3

High-throughput

0.489

High

176565

GRRE1
Granule associated Rac and RHOG effector protein 1

1

1

High-throughput

0.479

High

274253

ANR17
Ankyrin repeat domain-containing protein 17

1

1

High-throughput

0.479

High

404519

GCR
Glucocorticoid receptor

1

3

High-throughput

0.479

High

907614

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.479

High

1165519

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

7

High-throughput

0.479

High

1252409

MEX3B
RNA-binding protein MEX3B

1

3

High-throughput

0.479

High

1280764

YTHD3
YTH domain-containing family protein 3

1

6

High-throughput

0.479

High

1365381

CNOT9
CCR4-NOT transcription complex subunit 9

1

5

High-throughput

0.479

High

1419549

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

5

High-throughput

0.479

High

1420676

UNK
RING finger protein unkempt homolog

1

6

High-throughput

0.479

High

1438066

RC3H2
Roquin-2

1

6

Small-scale

0.479

High

1459121

YTHD2
YTH domain-containing family protein 2

1

6

High-throughput

0.479

High

346449

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

583004

EZRI
Ezrin

1

0

High-throughput

0.458

High

715827

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

935245

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

1108251

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1339216

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1391064

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.458

High

1429385

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1437968

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

1219904

OBI1
ORC ubiquitin ligase 1

1

1

High-throughput

0.437

High

1292775

LDHD
Probable D-lactate dehydrogenase, mitochondrial

1

1

High-throughput

0.437

High

1227636

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

1459122

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

49368

A0N4V7
HCG2039797

1

0

High-throughput

0.249

Low

268943

FCG3B
Low affinity immunoglobulin gamma Fc region receptor III-B

1

0

High-throughput

0.249

Low

1219567

LIPM
Lipase member M

1

0

High-throughput

0.249

Low

1356631

CT55
Cancer/testis antigen 55

1

0

High-throughput

0.249

Low

1434148

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025