HitPredict

Interactor 1: AP2A2 (O94973)
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)
Gene: AP2A2

Interactor 2: AAK1 (Q2M2I8)
AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)
Gene: AAK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 939 Hs			1 961
+	Hs
		321559 AP2A1_HUMAN (1-939): 0: 832: 78.47		AAK1_HUMAN (1-961): 0: 720: 100.00
+	Hs
		925884 AP2B1_HUMAN (36-933): 0: 607: 16.62		AAK1_HUMAN (1-961): 0: 720: 100.00
+	Hs
		1014021 AP1B1_HUMAN (36-934): 0: 606: 17.35		AAK1_HUMAN (1-961): 0: 720: 100.00
+	Hs
		302214 AP2A2_HUMAN (1-939): 0: 884: 100.00		BMP2K_HUMAN (37-767): 7.31e-125: 409: 47.28
+	Mm
		567521 AP2A2_MOUSE (1-939): 0: 891: 96.70		TNIK_MOUSE (24-782): 6.51e-116: 388: 13.73
+	Hs
		321653 AP2A1_HUMAN (1-939): 0: 832: 78.47		BMP2K_HUMAN (37-767): 7.31e-125: 409: 47.28
+	Mm
		567496 AP2A1_MOUSE (1-939): 0: 830: 79.33		TNIK_MOUSE (24-782): 6.51e-116: 388: 13.73
+	Dm
		954827 AP2A_DROME (3-939): 0: 819: 69.50		Q7KT38_DROME (1-634): 7.93e-120: 383: 36.12
+	Hs
		161600 AP2A2_HUMAN (1-939): 0: 884: 100.00		GAK_HUMAN (18-309): 7.18e-44: 175: 38.33
+	Hs
		926022 AP2B1_HUMAN (36-933): 0: 607: 16.62		BMP2K_HUMAN (37-767): 7.31e-125: 409: 47.28
+	Hs
		1014089 AP1B1_HUMAN (36-934): 0: 606: 17.35		BMP2K_HUMAN (37-767): 7.31e-125: 409: 47.28
+	Hs
		161603 AP2A1_HUMAN (1-939): 0: 832: 78.47		GAK_HUMAN (18-309): 7.18e-44: 175: 38.33
+	Mm
		949409 AP2B1_MOUSE (36-933): 0: 607: 16.51		TNIK_MOUSE (24-782): 6.51e-116: 388: 13.73
+	Hs
		212600 AP1G1_HUMAN (1-811): 0: 616: 25.12		AKT2_HUMAN (11-386): 3.23e-117: 369: 17.69
+	Hs
		926058 AP2B1_HUMAN (36-933): 0: 607: 16.62		AKT3_HUMAN (8-386): 1.3e-117: 370: 17.81
+	Dm
		1096899 Q24253_DROME (36-934): 0: 587: 16.26		Q7KT38_DROME (1-634): 7.93e-120: 383: 36.12
+	Dm
		1181922 Q7KVR8_DROME (12-705): 0: 553: 26.60		Q7KT38_DROME (1-634): 7.93e-120: 383: 36.12
+	Hs
		161644 AP2B1_HUMAN (36-933): 0: 607: 16.62		GAK_HUMAN (18-309): 7.18e-44: 175: 38.33
+	Hs
		150139 AP3D1_HUMAN (11-478): 3.33e-33: 140: 23.51		NUAK1_HUMAN (43-478): 6.05e-102: 334: 23.21