Protein: VAV
Proto-oncogene vav

Gene: VAV, VAV1
Organism: Homo sapiens
Interactions: 197
UniProt ID: P15498

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0002768 - immune response-regulating cell surface receptor signaling pathway
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

584510

GRB2
Growth factor receptor-bound protein 2

9

20

Small-scale

0.972

High

584529

LCP2
Lymphocyte cytosolic protein 2

6

17

Small-scale

0.936

High

362701

EGFR
Epidermal growth factor receptor

6

20

Small-scale

0.934

High

584489

KSYK
Tyrosine-protein kinase SYK

4

20

Small-scale

0.918

High

584515

3BP2
SH3 domain-binding protein 2

4

10

Small-scale

0.918

High

584478

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

4

19

Small-scale

0.904

High

584511

RAC1
Ras-related C3 botulinum toxin substrate 1

3

20

Small-scale

0.853

High

362147

ABL1
Tyrosine-protein kinase ABL1

2

20

Small-scale

0.847

High

584504

CDC42
Cell division control protein 42 homolog

3

20

Small-scale

0.840

High

584488

ZAP70
Tyrosine-protein kinase ZAP-70

3

20

Small-scale

0.827

High

193198

SOCS1
Suppressor of cytokine signaling 1

3

20

Small-scale

0.827

High

584465

ARF4
ADP-ribosylation factor 4

3

3

High-throughput

0.817

High

253286

JAK2
Tyrosine-protein kinase JAK2

2

20

Small-scale

0.806

High

584467

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

6

Small-scale

0.806

High

584505

RHOA
Transforming protein RhoA

2

20

Small-scale

0.778

High

584481

MK01
Mitogen-activated protein kinase 1

2

3

Small-scale

0.776

High

440335

FYN
Tyrosine-protein kinase Fyn

2

20

Small-scale

0.757

High

584461

VAV
Proto-oncogene vav

2

17

High-throughput

0.754

High

584483

TYK2
Non-receptor tyrosine-protein kinase TYK2

2

20

Small-scale

0.754

High

584472

CBL
E3 ubiquitin-protein ligase CBL

7

20

Small-scale

0.747

High

410582

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.738

High

584470

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.738

High

320531

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

2

11

High-throughput

0.737

High

484038

PGFRB
Platelet-derived growth factor receptor beta

2

20

Small-scale

0.727

High

584495

KLK7
Kallikrein-7

2

1

High-throughput

0.726

High

584534

SLAP1
Src-like-adapter

1

20

Small-scale

0.724

High

584545

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.724

High

584536

GAB1
GRB2-associated-binding protein 1

1

19

High-throughput

0.692

High

584491

NOTC1
Neurogenic locus notch homolog protein 1

1

3

High-throughput

0.691

High

584601

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

18

Small-scale

0.691

High

584486

IL6RB
Interleukin-6 receptor subunit beta

1

15

Small-scale

0.681

High

457209

TBB5
Tubulin beta chain

4

10

Small-scale

0.672

High

583959

CD19
B-lymphocyte antigen CD19

3

3

Small-scale

0.664

High

584562

TBA1A
Tubulin alpha-1A chain

3

10

Small-scale

0.660

High

163048

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.656

High

584528

MERTK
Tyrosine-protein kinase Mer

1

20

Small-scale

0.653

High

439632

INSR
Insulin receptor

1

20

Small-scale

0.647

High

584482

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

20

Small-scale

0.647

High

584539

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.647

High

584544

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

584565

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

584582

RGAP1
Rac GTPase-activating protein 1

1

14

Small-scale

0.647

High

584589

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

4

Small-scale

0.647

High

584532

CBLB
E3 ubiquitin-protein ligase CBL-B

2

20

Small-scale

0.639

High

220347

LAT
Linker for activation of T-cells family member 1

2

6

Small-scale

0.629

High

584508

ACTA
Actin, aortic smooth muscle

2

10

High-throughput

0.628

High

584518

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

1

High-throughput

0.628

High

584524

APLP2
Amyloid beta precursor like protein 2

2

6

High-throughput

0.628

High

584551

ACTBL
Beta-actin-like protein 2

2

16

High-throughput

0.628

High

584555

CYTSA
Cytospin-A

2

20

High-throughput

0.628

High

584564

SPA12
Serpin A12

2

1

High-throughput

0.628

High

584568

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

2

1

High-throughput

0.628

High

584602

NUB1
NEDD8 ultimate buster 1

2

1

High-throughput

0.628

High

171169

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

4

High-throughput

0.618

High

177783

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

8

Small-scale

0.618

High

270307

WDR1
WD repeat-containing protein 1

1

9

High-throughput

0.618

High

285064

EED
Polycomb protein EED

1

8

Small-scale

0.618

High

400231

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

Small-scale

0.618

High

584463

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

6

Small-scale

0.618

High

584468

EPOR
Erythropoietin receptor

1

18

Small-scale

0.618

High

584487

TEC
Tyrosine-protein kinase Tec

1

20

Small-scale

0.618

High

584490

CRK
Adapter molecule crk

1

18

Small-scale

0.618

High

584520

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

10

Small-scale

0.618

High

584522

KPCT
Protein kinase C theta type

1

12

Small-scale

0.618

High

584523

BTK
Tyrosine-protein kinase BTK

1

20

Small-scale

0.618

High

584554

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.618

High

584560

POTEE
POTE ankyrin domain family member E

1

18

High-throughput

0.618

High

584570

BLNK
B-cell linker protein

1

20

Small-scale

0.618

High

584571

DOCK2
Dedicator of cytokinesis protein 2

1

6

Small-scale

0.618

High

584595

ANFY1
Rabankyrin-5

1

5

High-throughput

0.618

High

584546

CDSN
Corneodesmosin

2

0

High-throughput

0.602

High

584556

PLBL1
Phospholipase B-like 1

2

0

High-throughput

0.602

High

584462

PRLR
Prolactin receptor

2

20

Small-scale

0.595

High

584525

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

2

8

Small-scale

0.595

High

584506

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

3

1

High-throughput

0.578

High

584584

GHC1
Mitochondrial glutamate carrier 1

3

8

High-throughput

0.578

High

584548

EZH2
Histone-lysine N-methyltransferase EZH2

2

2

Small-scale

0.576

High

374381

RASH
GTPase HRas

1

16

Small-scale

0.575

High

439933

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.575

High

584476

IKBA
NF-kappa-B inhibitor alpha

1

5

Small-scale

0.575

High

584600

PLAK2
PALM2-AKAP2 fusion protein

2

2

High-throughput

0.574

High

211533

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

4

Small-scale

0.573

High

557829

XRCC6
X-ray repair cross-complementing protein 6

1

4

Small-scale

0.573

High

584498

GDIR2
Rho GDP-dissociation inhibitor 2

1

3

Small-scale

0.573

High

240049

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

3

High-throughput

0.571

High

258749

DNJA2
DnaJ homolog subfamily A member 2

2

6

High-throughput

0.571

High

409247

HLAA
HLA class I histocompatibility antigen, A alpha chain

2

2

High-throughput

0.571

High

415324

HSPB1
Heat shock protein beta-1

2

5

High-throughput

0.571

High

420339

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

2

2

High-throughput

0.571

High

424757

ADT2
ADP/ATP translocase 2

2

5

High-throughput

0.571

High

549528

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

3

High-throughput

0.571

High

584475

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

2

5

High-throughput

0.571

High

584477

PYR1
Multifunctional protein CAD

2

7

High-throughput

0.571

High

584484

DNJA1
DnaJ homolog subfamily A member 1

2

6

High-throughput

0.571

High

584492

AL1A3
Retinaldehyde dehydrogenase 3

2

2

High-throughput

0.571

High

584503

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

3

High-throughput

0.571

High

584509

RL23
Large ribosomal subunit protein uL14

2

2

High-throughput

0.571

High

584512

RL38
Large ribosomal subunit protein eL38

2

1

High-throughput

0.571

High

584513

TBA1B
Tubulin alpha-1B chain

2

10

High-throughput

0.571

High

584514

TBB4B
Tubulin beta-4B chain

2

10

High-throughput

0.571

High

584516

S25A3
Solute carrier family 25 member 3

2

7

High-throughput

0.571

High

584521

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

2

10

High-throughput

0.571

High

584533

PSMD2
26S proteasome non-ATPase regulatory subunit 2

2

1

High-throughput

0.571

High

584537

TBB3
Tubulin beta-3 chain

2

10

High-throughput

0.571

High

584540

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

3

High-throughput

0.571

High

584558

TBA3E
Tubulin alpha-3E chain

2

8

High-throughput

0.571

High

584594

VAPA
Vesicle-associated membrane protein-associated protein A

2

2

High-throughput

0.571

High

584604

NS1BP
Influenza virus NS1A-binding protein

2

7

High-throughput

0.571

High

584567

ZN655
Zinc finger protein 655

1

0

Small-scale

0.561

High

407573

S100B
Protein S100-B

1

8

Small-scale

0.561

High

584527

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.547

High

563128

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.541

High

519713

ANDR
Androgen receptor

1

18

High-throughput

0.536

High

276562

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

1

High-throughput

0.536

High

584519

DSG1
Desmoglein-1

1

5

High-throughput

0.536

High

584572

APBB2
Amyloid beta precursor protein binding family B member 2

1

1

High-throughput

0.536

High

584575

DNJC1
DnaJ homolog subfamily C member 1

1

6

High-throughput

0.536

High

541313

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.527

High

584579

DOK1
Docking protein 1

1

15

Small-scale

0.527

High

552113

ADT3
ADP/ATP translocase 3

2

5

High-throughput

0.521

High

584494

EFTU
Elongation factor Tu, mitochondrial

2

6

High-throughput

0.521

High

584500

TXTP
Tricarboxylate transport protein, mitochondrial

2

8

High-throughput

0.521

High

584526

SRSF4
Serine/arginine-rich splicing factor 4

2

14

High-throughput

0.521

High

584535

SRSF6
Serine/arginine-rich splicing factor 6

2

15

High-throughput

0.521

High

584549

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

2

3

High-throughput

0.521

High

584573

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

2

1

High-throughput

0.521

High

584596

DIC
Mitochondrial dicarboxylate carrier

2

9

High-throughput

0.521

High

539454

ITAM
Integrin alpha-M

1

2

Small-scale

0.515

High

584587

SMC4
Structural maintenance of chromosomes protein 4

1

7

High-throughput

0.515

High

424480

PAI2
Plasminogen activator inhibitor 2

1

0

High-throughput

0.513

High

584583

PHAX
Phosphorylated adapter RNA export protein

1

0

High-throughput

0.486

High

584563

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

Small-scale

0.481

High

123043

DX39A
ATP-dependent RNA helicase DDX39A

1

9

High-throughput

0.479

High

158108

COPE
Coatomer subunit epsilon

1

3

High-throughput

0.479

High

159142

ABLM1
Actin-binding LIM protein 1

1

16

High-throughput

0.479

High

172450

XPO1
Exportin-1

1

12

High-throughput

0.479

High

214274

MSI1H
RNA-binding protein Musashi homolog 1

1

16

High-throughput

0.479

High

245780

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

2

High-throughput

0.479

High

299052

FLOT1
Flotillin-1

1

11

High-throughput

0.479

High

407969

TBB4A
Tubulin beta-4A chain

1

10

High-throughput

0.479

High

424055

ITB2
Integrin beta-2

1

3

Small-scale

0.479

High

450921

LDHB
L-lactate dehydrogenase B chain

1

3

High-throughput

0.479

High

532157

CD28
T-cell-specific surface glycoprotein CD28

1

1

Small-scale

0.479

High

559206

XRCC5
X-ray repair cross-complementing protein 5

1

4

Small-scale

0.479

High

584466

EGR1
Early growth response protein 1

1

3

High-throughput

0.479

High

584469

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

5

High-throughput

0.479

High

584471

NDKB
Nucleoside diphosphate kinase B

1

4

High-throughput

0.479

High

584473

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

7

High-throughput

0.479

High

584474

COF1
Cofilin-1

1

6

High-throughput

0.479

High

584479

ABCD3
ATP-binding cassette sub-family D member 3

1

4

High-throughput

0.479

High

584480

TMOD1
Tropomodulin-1

1

10

High-throughput

0.479

High

584493

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

2

High-throughput

0.479

High

584507

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

16

Small-scale

0.479

High

584531

PRDX4
Peroxiredoxin-4

1

6

High-throughput

0.479

High

584538

FLOT2
Flotillin-2

1

11

High-throughput

0.479

High

584541

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

Small-scale

0.479

High

584543

PLEC
Plectin

1

20

High-throughput

0.479

High

584552

RIF1
Telomere-associated protein RIF1

1

16

High-throughput

0.479

High

584553

ECM29
Proteasome adapter and scaffold protein ECM29

1

10

High-throughput

0.479

High

584559

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

1

2

High-throughput

0.479

High

584566

NUP93
Nuclear pore complex protein Nup93

1

2

High-throughput

0.479

High

584577

NEB2
Neurabin-2

1

20

High-throughput

0.479

High

584578

CHP1
Calcineurin B homologous protein 1

1

2

High-throughput

0.479

High

584585

SP110
Sp110 nuclear body protein

1

4

High-throughput

0.479

High

584588

LIN7C
Protein lin-7 homolog C

1

14

High-throughput

0.479

High

584590

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

5

High-throughput

0.479

High

584593

HACD3
Very-long-chain

1

1

High-throughput

0.479

High

584598

RUVB1
RuvB-like 1

1

4

High-throughput

0.479

High

584599

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

2

High-throughput

0.479

High

584603

SRPRB
Signal recognition particle receptor subunit beta

1

6

High-throughput

0.479

High

584464

SPI1
Transcription factor PU.1

1

2

Small-scale

0.470

High

584496

EMD
Emerin

1

0

Small-scale

0.460

High

584517

FCERB
High affinity immunoglobulin epsilon receptor subunit beta

1

0

Small-scale

0.458

High

584542

SUZ12
Polycomb protein SUZ12

1

0

Small-scale

0.458

High

584597

RTRAF
RNA transcription, translation and transport factor protein

1

0

High-throughput

0.458

High

429244

JUN
Transcription factor Jun

1

1

Small-scale

0.457

High

176020

KDM6B
Lysine-specific demethylase 6B

1

8

Small-scale

0.437

High

566534

PDIA4
Protein disulfide-isomerase A4

1

7

High-throughput

0.437

High

584485

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

3

High-throughput

0.437

High

584497

SERPH
Serpin H1

1

7

High-throughput

0.437

High

584530

TADBP
TAR DNA-binding protein 43

1

14

High-throughput

0.437

High

584557

RL22L
Ribosomal protein eL22-like

1

4

High-throughput

0.437

High

584581

SF3B5
Splicing factor 3B subunit 5

1

2

High-throughput

0.437

High

584586

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.437

High

584591

TECR
Very-long-chain enoyl-CoA reductase

1

2

High-throughput

0.437

High

584592

TMOD2
Tropomodulin-2

1

13

High-throughput

0.437

High

584569

HAVR2
Hepatitis A virus cellular receptor 2

1

0

Small-scale

0.426

High

584561

SBSN
Suprabasin

2

0

High-throughput

0.328

High

584499

RM12
Large ribosomal subunit protein bL12m

2

0

High-throughput

0.298

High

584501

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

2

0

High-throughput

0.298

High

584502

TMM33
Transmembrane protein 33

2

0

High-throughput

0.298

High

584550

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

2

0

High-throughput

0.298

High

584574

ATPMK
ATP synthase F(0) complex subunit k, mitochondrial

2

0

High-throughput

0.298

High

584580

RT63
Large ribosomal subunit protein mL63

2

0

High-throughput

0.298

High

584547

CYTM
Cystatin-M

1

0

High-throughput

0.279

Low

584576

VMA22
Vacuolar ATPase assembly protein VMA22

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025