HitPredict

Interactor 1: AP2A2 (O94973)
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)
Gene: AP2A2

Interactor 2: MYO6 (Q9UM54)
Unconventional myosin-VI (Unconventional myosin-6)
Gene: MYO6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	26950368, 29467281
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport GO:0031410 - cytoplasmic vesicle
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 939 Hs			1 1294
+	Hs
		321671 AP2A1_HUMAN (1-939): 0: 832: 78.47		MYO6_HUMAN (1-1294): 0: 1083: 100.00
+	Hs
		926052 AP2B1_HUMAN (36-933): 0: 607: 16.62		MYO6_HUMAN (1-1294): 0: 1083: 100.00
+	Hs
		150277 AP3D1_HUMAN (11-478): 3.33e-33: 140: 23.51		MYO6_HUMAN (1-1294): 0: 1083: 100.00
+	Hs
		321651 AP2A1_HUMAN (1-939): 0: 832: 78.47		MYO5C_HUMAN (772-1230): 2.22e-24: 113: 9.42
+	Hs
		321498 AP2A1_HUMAN (1-939): 0: 832: 78.47		MYH9_HUMAN (842-1118): 6.25e-10: 66.2: 14.70
+	Hs
		724758 AP2B1_HUMAN (36-933): 0: 607: 16.62		MYH9_HUMAN (842-1118): 6.25e-10: 66.2: 14.70