Protein: RIPK2
Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)

Gene: RIPK2
Organism: Homo sapiens
Interactions: 124
UniProt ID: O43353

Gene Ontology (top 5):
GO:0001961 - positive regulation of cytokine-mediated signaling pathway
GO:0002250 - adaptive immune response
GO:0002827 - positive regulation of T-helper 1 type immune response
GO:0004674 - protein serine/threonine kinase activity
GO:0004706 - JUN kinase kinase kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

201782

XIAP
E3 ubiquitin-protein ligase XIAP

14

20

Small-scale

0.988

High

201829

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

20

15

Small-scale

0.986

High

201728

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

9

17

Small-scale

0.971

High

201835

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

7

10

Small-scale

0.956

High

201791

BIRC2
Baculoviral IAP repeat-containing protein 2

5

20

Small-scale

0.939

High

201759

CASP1
Caspase-1

6

8

Small-scale

0.935

High

201131

M3K7
Mitogen-activated protein kinase kinase kinase 7

4

20

Small-scale

0.894

High

201790

BIRC3
Baculoviral IAP repeat-containing protein 3

3

17

Small-scale

0.889

High

201777

1433E
14-3-3 protein epsilon

2

7

Small-scale

0.806

High

201776

1433G
14-3-3 protein gamma

2

20

Small-scale

0.800

High

201804

CAR16
Caspase recruitment domain-containing protein 16

2

2

Small-scale

0.776

High

201826

CARD6
Caspase recruitment domain-containing protein 6

2

3

Small-scale

0.776

High

201748

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

4

Small-scale

0.768

High

201729

TLR2
Toll-like receptor 2

2

20

Small-scale

0.754

High

201769

IRAK1
Interleukin-1 receptor-associated kinase 1

2

20

Small-scale

0.754

High

201757

1433T
14-3-3 protein theta

1

20

Small-scale

0.724

High

201763

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.724

High

201839

TRAF6
TNF receptor-associated factor 6

5

20

Small-scale

0.702

High

201733

STK10
Serine/threonine-protein kinase 10

1

9

High-throughput

0.691

High

201784

1433F
14-3-3 protein eta

1

20

High-throughput

0.691

High

201828

SLK
STE20-like serine/threonine-protein kinase

1

7

High-throughput

0.691

High

201788

TRAF3
TNF receptor-associated factor 3

3

20

Small-scale

0.683

High

201825

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

2

0

High-throughput

0.679

High

201785

TRAF2
TNF receptor-associated factor 2

3

20

Small-scale

0.667

High

201773

ANM2
Protein arginine N-methyltransferase 2

1

1

High-throughput

0.656

High

201802

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

0

High-throughput

0.656

High

201840

NEMO
NF-kappa-B essential modulator

3

11

Small-scale

0.650

High

167421

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

10

Small-scale

0.647

High

201730

ULK1
Serine/threonine-protein kinase ULK1

1

4

Small-scale

0.647

High

201805

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

Small-scale

0.647

High

201792

SQSTM
Sequestosome-1

3

10

Small-scale

0.640

High

120113

TLR4
Toll-like receptor 4

1

20

Small-scale

0.618

High

201731

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

1

Small-scale

0.618

High

201737

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.618

High

201745

TNR16
Tumor necrosis factor receptor superfamily member 16

1

10

Small-scale

0.618

High

201750

EZRI
Ezrin

1

8

High-throughput

0.618

High

201753

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

10

Small-scale

0.618

High

201764

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

201793

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

17

Small-scale

0.618

High

201809

CASPC
Inactive caspase-12

1

8

Small-scale

0.618

High

201827

CARD9
Caspase recruitment domain-containing protein 9

1

5

Small-scale

0.618

High

201832

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

1

9

Small-scale

0.618

High

201833

ASC
Apoptosis-associated speck-like protein containing a CARD

1

1

Small-scale

0.618

High

201842

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

8

Small-scale

0.618

High

201732

ERLN1
Erlin-1

2

1

Small-scale

0.611

High

201735

ERLN2
Erlin-2

2

1

Small-scale

0.611

High

201810

MAVS
Mitochondrial antiviral-signaling protein

1

3

High-throughput

0.597

High

201807

A16L1
Autophagy-related protein 16-1

2

3

Small-scale

0.595

High

201746

VIME
Vimentin

2

2

High-throughput

0.584

High

201799

IRF4
Interferon regulatory factor 4

2

1

Small-scale

0.584

High

201815

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

1

2

Small-scale

0.578

High

201818

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

2

Small-scale

0.561

High

201781

UBC9
SUMO-conjugating enzyme UBC9

1

3

High-throughput

0.541

High

49650

IRGM
Immunity-related GTPase family M protein

1

0

Small-scale

0.537

High

201786

PP1R8
Nuclear inhibitor of protein phosphatase 1

1

4

High-throughput

0.536

High

201836

STRAP
Serine-threonine kinase receptor-associated protein

1

2

High-throughput

0.536

High

201841

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

4

High-throughput

0.536

High

181572

CFLAR
CASP8 and FADD-like apoptosis regulator

1

7

Small-scale

0.515

High

201787

TRAF1
TNF receptor-associated factor 1

1

20

Small-scale

0.515

High

201801

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

5

Small-scale

0.515

High

201830

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

3

Small-scale

0.515

High

61263

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.513

High

201811

CF120
UPF0669 protein C6orf120

1

0

High-throughput

0.513

High

201821

COG3
Conserved oligomeric Golgi complex subunit 3

1

0

High-throughput

0.513

High

201838

KDM3A
Lysine-specific demethylase 3A

1

2

High-throughput

0.508

High

201778

RS14
Small ribosomal subunit protein uS11

1

0

High-throughput

0.493

High

201779

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.493

High

201819

KCD12
BTB/POZ domain-containing protein KCTD12

1

0

High-throughput

0.493

High

201822

PHB2
Prohibitin-2

1

0

High-throughput

0.493

High

201796

BECN1
Beclin-1

1

0

Small-scale

0.480

High

129516

TRAF5
TNF receptor-associated factor 5

1

20

Small-scale

0.479

High

156173

PSA7
Proteasome subunit alpha type-7

1

2

High-throughput

0.479

High

201734

MYO1D
Unconventional myosin-Id

1

7

High-throughput

0.479

High

201739

TBB4A
Tubulin beta-4A chain

1

20

High-throughput

0.479

High

201743

TBB5
Tubulin beta chain

1

20

High-throughput

0.479

High

201744

HS90A
Heat shock protein HSP 90-alpha

1

17

High-throughput

0.479

High

201747

CLCA
Clathrin light chain A

1

1

High-throughput

0.479

High

201749

HSP7C
Heat shock cognate 71 kDa protein

1

12

High-throughput

0.479

High

201751

HSP76
Heat shock 70 kDa protein 6

1

12

High-throughput

0.479

High

201752

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

2

Small-scale

0.479

High

201754

VDAC1
Voltage-dependent anion-selective channel protein 1

1

5

High-throughput

0.479

High

201756

TNR5
Tumor necrosis factor receptor superfamily member 5

1

10

Small-scale

0.479

High

201758

PSB5
Proteasome subunit beta type-5

1

2

High-throughput

0.479

High

201765

HS71L
Heat shock 70 kDa protein 1-like

1

12

High-throughput

0.479

High

201766

MYH9
Myosin-9

1

3

High-throughput

0.479

High

201767

MYH10
Myosin-10

1

2

High-throughput

0.479

High

201768

PERI
Peripherin

1

2

High-throughput

0.479

High

201771

HSP72
Heat shock-related 70 kDa protein 2

1

12

High-throughput

0.479

High

201772

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

4

High-throughput

0.479

High

201775

PSA6
Proteasome subunit alpha type-6

1

2

High-throughput

0.479

High

201780

ACTG
Actin, cytoplasmic 2

1

4

High-throughput

0.479

High

201783

FABP5
Fatty acid-binding protein 5

1

1

High-throughput

0.479

High

201789

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

2

High-throughput

0.479

High

201794

CUL3
Cullin-3

1

2

High-throughput

0.479

High

201795

TRI14
Tripartite motif-containing protein 14

1

9

High-throughput

0.479

High

201797

NBR1
Next to BRCA1 gene 1 protein

1

2

Small-scale

0.479

High

201812

NLRX1
NLR family member X1

1

5

High-throughput

0.479

High

201813

TCAM1
TIR domain-containing adapter molecule 1

1

4

Small-scale

0.479

High

201820

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

Small-scale

0.479

High

201823

TRAF4
TNF receptor-associated factor 4

1

20

Small-scale

0.479

High

201824

TBB2B
Tubulin beta-2B chain

1

20

High-throughput

0.479

High

201831

Q9NZ23
Drug-sensitive protein 1

1

1

High-throughput

0.479

High

201834

Q9UQC1
Heat shock protein 72

1

15

High-throughput

0.479

High

201736

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

201740

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

201742

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

201755

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.458

High

201760

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

201774

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.458

High

201798

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

201800

TRIP6
Thyroid receptor-interacting protein 6

1

0

Small-scale

0.458

High

201808

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

High-throughput

0.458

High

201814

RN168
E3 ubiquitin-protein ligase RNF168

1

0

Small-scale

0.458

High

201817

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

201837

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.458

High

201762

ECHM
Enoyl-CoA hydratase, mitochondrial

1

5

High-throughput

0.437

High

201770

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

1

High-throughput

0.437

High

201741

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.426

High

201806

RM02
Large ribosomal subunit protein uL2m

1

0

High-throughput

0.279

Low

201738

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.249

Low

201761

ATPD
ATP synthase subunit delta, mitochondrial

1

0

High-throughput

0.249

Low

201803

GXLT1
Glucoside xylosyltransferase 1

1

0

High-throughput

0.249

Low

201816

NAT16
Probable N-acetyltransferase 16

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024