HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.937

The method score is based on:

Property Details
Experiments 26949039, 28425671, 28689657, 31365120, 37040767, 22496338
Identification Methods enzymatic study, affinity chromatography technology, x-ray crystallography
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains E3_UbLigase_EDD~E3_UbLigase_EDD, HECT~HECT, PABP~PABP
Common GO terms GO:0000209 - protein polyubiquitination
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 17 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 2799
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024