HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.862

Property	Details
Experiments	28190767, 38803224, 17897937
Identification Methods	pull down, x-ray crystallography
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	E3_UbLigase_EDD~ubiquitin, HECT~ubiquitin
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2799 Hs			1 685
+	Hs
		304113 UBR5_HUMAN (1-2799): 0: 3949: 100.00		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Mm
		476862 UBR5_MOUSE (1-2799): 0: 3938: 97.89		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		475963 HECW1_HUMAN (2170-2798): 2.44e-168: 568: 20.31		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476414 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476403 SMUF2_HUMAN (2405-2796): 3.89e-134: 442: 22.36		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476205 ITCH_HUMAN (2187-2797): 8.94e-132: 440: 18.08		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		125113 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475799 UBE3C_HUMAN (2301-2796): 5.2e-128: 435: 20.33		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476350 WWP1_HUMAN (2180-2797): 2.84e-126: 425: 18.43		UBC_HUMAN (1-685): 0: 846: 100.00
+	Dm
		89879 D5SHR3_DROME (2366-2797): 2.99e-133: 427: 20.81		UBIQP_DROME (1-610): 0: 752: 99.84
+	Dm
		1376481 Q9W325_DROME (2355-2797): 3.11e-133: 427: 20.52		Q9W418_DROME (229-685): 0: 557: 99.78
+	At
		1091758 UPL1_ARATH (2398-2798): 1.97e-122: 438: 22.30		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		1091762 UPL2_ARATH (2398-2798): 1.26e-121: 435: 22.54		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Hs
		125347 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Rn
		1140970 Q5YB86_RAT (2187-2797): 2.68e-133: 443: 18.24		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Mm
		476866 UBE3C_MOUSE (2301-2796): 1.1e-128: 437: 20.33		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		475196 SMUF2_HUMAN (2405-2796): 3.89e-134: 442: 22.36		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		475140 ITCH_HUMAN (2187-2797): 8.94e-132: 440: 18.08		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		125112 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Mm
		1321822 SMUF1_MOUSE (2357-2796): 2.95e-142: 465: 21.18		OASL2_MOUSE (152-298): 8.11e-11: 67: 26.97